Navigation Links
Could patients' own kidney cells cure kidney disease?
Date:7/27/2011

  • Patients' own kidney cells can be reprogrammed and used as therapy against kidney disease
  • Cells can easily be collected from the urine
  • 88,000 patients are waiting for a kidney transplant in the United States, and they wait for an average of 3 to 5 years

Washington, DC (July 27, 2011) Approximately 60 million people across the globe have chronic kidney disease, and many will need dialysis or a transplant. Breakthrough research published in the Journal of the American Society Nephrology (JASN) indicates that patients' own kidney cells can be gathered and reprogrammed. Reprogramming patients' kidney cells could mean that in the future, fewer patients with kidney disease would require complicated, expensive procedures that affect their quality of life.

In the first study, Sharon Ricardo, PhD (Monash University, in Clayton, Australia) and her colleagues took cells from an individual's kidney and coaxed them to become progenitor cells, allowing the immature cells to form any type in the kidney. Specifically, they inserted several key reprogramming genes into the renal cells that made them capable of forming other cells.

In a second study, Miguel Esteban, MD, PhD (Chinese Academy of Sciences, in Guangzhou, China) and his colleagues found that kidney cells collected from a patient's urine can also be reprogrammed in this way. Using cells from urine allows a technology easy to implement in a clinic setting. Even better, the urine cells could be frozen and later thawed before they were manipulated.

If researchers can expand the reprogrammed cellscalled induced pluripotent stem cells (iPSCs)and return them to the patient, these IPSCs may restore the health and vitality of the kidneys. In addition to providing a potentially curative therapy for patients, the breakthroughs might also help investigators to study the causes of kidney disease and to screen new drugs that could be used to treat them.

In an accompanying editorial, Ian Rogers, PhD (Mount Sinai Hospital, in Toronto, Ontario, Canada) noted that "together, these two articles demonstrate the feasibility of using kidney cells as a source of iPSCs, and efficient production of adult iPSCs from urine means that cells can be collected at any time."

Just as exciting, the ease of collection and high frequency of reprogramming described in these articles may help improve future therapies in many other areas of medicine.


'/>"/>

Contact: Adrienne Lea
alea@asn-online.org
202-503-6560
American Society of Nephrology
Source:Eurekalert

Related biology news :

1. Strong El Niño could bring increased sea levels, storm surges to US East Coast
2. Penn vet researchers show lymphoma drug shrinks dog tumors, could lead to human treatment
3. New understanding of biomarkers could lead to earlier diagnosis of fatal diseases
4. New material could offer hope to those with no voice
5. Acidifying oceans could hit California mussels, a key species
6. PSA test for men could get a second life for breast cancer in women
7. Smelly socks could be a key to preventing malaria deaths in the developing world
8. University of Kentucky-led research could be path to new energy sources
9. Microalgae could be Texas next big cash crop
10. A mothers salt intake could be key to prenatal kidney development
11. New laser technology could kill viruses and improve DVDs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... BARCELONA, Spain , Feb. 24, 2017  EyeLock LLC, ... will demonstrate its elite iris biometric solution on ... with X16 LTE at Mobile World Congress ... in Qualcomm,s Booth in Hall 3, Stand ... contains the Qualcomm Haven™ security platform—a combination ...
(Date:2/21/2017)... PORTLAND, Ore. , Feb. 22, 2017 ... Family of Companies (Avamere Health Services, Infinity Rehab, Signature ... research study that will apply the power of IBM ... living and health centers. By analyzing data streaming from ... insights into physical and environmental conditions, and obtain deeper ...
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a ... announced that it has received Laboratory Accreditation from ... Accreditation is presented to laboratories that meet stringent ... demonstrate scientifically rigorous processes. "Genos is ... in laboratory practices. We,re honored to be receiving ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... 2017  The global market for clinical laboratory ... a new report from Kalorama Information.  In addition ... to evaluate disease progression, monitor drug treatment and ... The healthcare market research firm,s report, ... overview of the medical laboratory industry and the ...
(Date:3/27/2017)... 2017  Trovagene, Inc. (NASDAQ: TROV), a precision medicine ... Bill Welch , will be presenting at this ... AM EDT at the Essex House in ... Scientific Officer, Mark Erlander , Ph.D., will also ... The presentation will be webcast live at ...
(Date:3/24/2017)... , Mar. 24, 2017 Research and Markets ... (hESC) Research - Global Strategic Business Report" report to their ... This ... Research in US$ Million. Annual estimates and forecasts are provided for ... from primary and secondary research. The report profiles ...
(Date:3/23/2017)... ... March 23, 2017 , ... AxioMed ... both viscous and elastic characteristics when deformed, which is identical to how the ... gently absorb compressive forces and return to its natural state along a hysteresis ...
Breaking Biology Technology: