Navigation Links
Could metabolism play a role in epilepsy?
Date:2/19/2014

February 19Researchers from the Franciscan University of Steubenville, Ohio are exploring a possible link between metabolic defects and seizures. They determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be useful in treating disorders such as epilepsy.

Dr. Daniel Kuebler, the principal investigator behind the experiment, and his lab made the connection by measuring fruit fly movement with inexpensive web-cams. They have published a peer-reviewed, video demonstration of their method in JoVE, the Journal of Visualized Experiments, to assist others in reproducing and further applying the method.

"This technique has allowed us to identify a number of metabolism-altering drugs that affect seizure susceptibility," said Dr. Kuebler, "It has opened up a new line of research looking at the effect dietary modifications have on seizure susceptibility." As published in the article, his lab team determined that metformin, a drug commonly used to treat type II diabetes, reduces the intensity of seizures.

The drug-screening model system is especially ideal for labs on a tight budget, said Dr. Kuebler. According to the article, "Video tracking systems have been used widely to analyze Drosophila melanogaster movement and detect various abnormalities in locomotive behavior. [But] while these systems can provide a wealth of behavioral information, the cost and complexity of these systems can be prohibitive for many labs." Unlike similar experiments, which study the behavior of these flies in aggregate, Dr. Kuebler and his team's approach studies fly behavior one at a time. This is beneficial in that it can determine subtle differences in behavior and seizure alterations, he said.

While there is no known trigger behind seizures in people with epilepsy, Dr. Kuebler and his lab are using their drug-screening technique to investigate potential metabolic
'/>"/>

Contact: Rachel Greene
rachel.greene@jove.com
617-250-8451
The Journal of Visualized Experiments
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Why tackling appetite could hold the key to preventing childhood obesity
2. First biological marker for major depression could enable better diagnosis and treatment
3. Small non-coding RNAs could be warning signs of cancer
4. A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
5. Asian longhorned beetles pheromone could be used to manage pest
6. Electronically controlled drugs could minimize side effects
7. Cell division finding could boost understanding of cancer
8. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
9. Genetic function discovered that could offer new avenue to cancer therapies
10. Secrets of potato blight evolution could help farmers fight back
11. Long-lived breast stem cells could retain cancer legacy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Could metabolism play a role in epilepsy?
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:3/31/2015)... March 31, 2015  Elephant Talk Communications Corp. (NYSE ... provider of Software Defined Network Architecture (ET Software DNA® ... revenue of approximately $20.4 million for the year ended ... million for the year ended December 31, 2013. ... Company had completed its multi-year transition away from its ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... Researchers at the University of Gothenburg, Sweden, have developed ... them to controlled environmental changes. The unique method, where ... in a microscopic channel system, allows the researchers to ... a constantly changing environment. Studies on how cells ...
... group of vertebrates sometimes assist a more dominant pair ... this has been shown to occur among subordinate female ... PLoS ONE , Dik Heg and colleagues at the ... suggest that rather than engaging in an act of ...
... available in German . , For modern ... is important to generate materials with characteristics that closely emulate ... of traits that are very hard to recreate in synthetic ... of Australian and Korean researchers led by Geoffrey M. Spinks ...
Cached Biology News:Using high-precision laser tweezers to juggle cells 2The importance of being helpful -- Cooperative cichlids boost their own reproductive success 2Progress toward artificial tissue? 2
(Date:4/17/2015)... Madison, WI (PRWEB) April 17, 2015 ... provide sales and marketing support for the powerful ... at the Chemical Genomics Center at the Lankenau ... LCGC’s mission is to measurably improve successful ... to HTS, by offering rare, drug-like libraries available ...
(Date:4/16/2015)... CAMBRIDGE, Mass. (PRWEB) April 16, 2015 ... of smart data solutions driven by Semantic Web ... provider of specialist information and services for the ... today announced that its joint solution ‘Smart Data ... named a finalist for the 2015 Bio-IT ‘Best ...
(Date:4/16/2015)... Irvine, CA (PRWEB) April 16, 2015 ... in the Buzz of BIO Contest for ... Industry Organization (BIO), the 2015 BIO International Convention will ... in Philadelphia, Pennsylvania. During the Buzz of BIO contest, ... like to see present at the conference. The community ...
(Date:4/16/2015)... According to the 2014 Liberty Mutual ... was ranked first among the leading causes of ... pushing, pulling, holding, carrying, or throwing and cost ... Round Company takes statistics like this very seriously. ... develop and design equipment that prevents these injuries ...
Breaking Biology Technology:BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... 2011 Avantra® Biosciences, a leading innovator in ... Avantra,s new service allows researchers to cost effectively ... assays developed on Avantra,s proven QPDx™ BioChip platform. ... multiplex protein assays using catalog or custom reagents. ...
... EntreMed, Inc. (Nasdaq: ENMD ), a ... cancer today announced the presentation of clinical data for ... cancer patients.   The data were presented by the ... medical director of gynecologic oncology at Dana-Farber Cancer Institute ...
... biopharmaceutical product launches have produced both noteworthy failures and ... a continually evolving launch landscape, organizations are rethinking the ... launch environment. In a new wide-ranging ... failure points facing new product launches, Best Practices, LLC ...
Cached Biology Technology:EntreMed's ENMD-2076 Demonstrates Clinical Activity in Recurrent, Platinum-Resistant Ovarian Cancer Patients 2EntreMed's ENMD-2076 Demonstrates Clinical Activity in Recurrent, Platinum-Resistant Ovarian Cancer Patients 3EntreMed's ENMD-2076 Demonstrates Clinical Activity in Recurrent, Platinum-Resistant Ovarian Cancer Patients 4Creating a Road Map for Successful Cardiovascular New Product Launch 2
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
... is an inhibitor of ... concentration of inhibitor required ... must be determined empirically ... micromolar inhibitor is sufficient ...
...
SNARE associated protein snapin, clone MGC:2717...
Biology Products: