Navigation Links
Could metabolism play a role in epilepsy?
Date:2/19/2014

February 19Researchers from the Franciscan University of Steubenville, Ohio are exploring a possible link between metabolic defects and seizures. They determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be useful in treating disorders such as epilepsy.

Dr. Daniel Kuebler, the principal investigator behind the experiment, and his lab made the connection by measuring fruit fly movement with inexpensive web-cams. They have published a peer-reviewed, video demonstration of their method in JoVE, the Journal of Visualized Experiments, to assist others in reproducing and further applying the method.

"This technique has allowed us to identify a number of metabolism-altering drugs that affect seizure susceptibility," said Dr. Kuebler, "It has opened up a new line of research looking at the effect dietary modifications have on seizure susceptibility." As published in the article, his lab team determined that metformin, a drug commonly used to treat type II diabetes, reduces the intensity of seizures.

The drug-screening model system is especially ideal for labs on a tight budget, said Dr. Kuebler. According to the article, "Video tracking systems have been used widely to analyze Drosophila melanogaster movement and detect various abnormalities in locomotive behavior. [But] while these systems can provide a wealth of behavioral information, the cost and complexity of these systems can be prohibitive for many labs." Unlike similar experiments, which study the behavior of these flies in aggregate, Dr. Kuebler and his team's approach studies fly behavior one at a time. This is beneficial in that it can determine subtle differences in behavior and seizure alterations, he said.

While there is no known trigger behind seizures in people with epilepsy, Dr. Kuebler and his lab are using their drug-screening technique to investigate potential metabolic
'/>"/>

Contact: Rachel Greene
rachel.greene@jove.com
617-250-8451
The Journal of Visualized Experiments
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Why tackling appetite could hold the key to preventing childhood obesity
2. First biological marker for major depression could enable better diagnosis and treatment
3. Small non-coding RNAs could be warning signs of cancer
4. A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
5. Asian longhorned beetles pheromone could be used to manage pest
6. Electronically controlled drugs could minimize side effects
7. Cell division finding could boost understanding of cancer
8. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
9. Genetic function discovered that could offer new avenue to cancer therapies
10. Secrets of potato blight evolution could help farmers fight back
11. Long-lived breast stem cells could retain cancer legacy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Could metabolism play a role in epilepsy?
(Date:8/1/2014)... of marine mammals have officially named a species ... Sousa sahulensis , according to the Wildlife Conservation ... describing the newly named species is the culmination ... available historical records, physical descriptions, and genetic data ... ranging from the coast of West Africa to ...
(Date:8/1/2014)... the conductive tissue through which plants transport carbohydrates and ... are capped at one end by a sieve plate ... turn form a network throughout a plant,s body. ... play an important role in carbon sequestration, yet so ... says Professor Yk Helariutta from the Institute of Biotechnology, ...
(Date:8/1/2014)... CAAugust 1, 2014Biologists at The Scripps Research Institute (TSRI) ... powerful calorie-burning process in brown fat cells. , ... Early Edition of the Proceedings of the National ... known as "brown fat thermogenesis," which is of great ... loss and may also protect against diabetes. , "This ...
Breaking Biology News(10 mins):Scientists name new species of cetacean: The Australian humpback dolphin 2Scientists name new species of cetacean: The Australian humpback dolphin 3Developmental regulation of important plant phloem components discovered 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3
... Congress demonstrated that initial treatment with adalimumab (Humira, ADA) plus ... disease control in many patients, and may also offer the ... Results of a study of 1032 patients with early (less ... after 26 weeks with ADA 40mg every other week + ...
... an economically and environmentally beneficial, ,bio-derived, Australian and ... proposition, according to a report compiled by CSIRO ... players.The report, Flight Path to Sustainable Aviation, predicts ... sustainable, Australia-New Zealand aviation fuels industry could cut ...
... Many kinds of algae and cyanobacteria, common water-dwelling microorganisms, ... water molecules and release hydrogen, which holds promise as ... reason this approach hasn,t yet been harnessed for fuel ... a back seat to the production of compounds that ...
Cached Biology News:Targeted adalimumab treatment can optimize long-term outcomes for patients with early RA 2Sustainable 'bio-derived' jet fuel industry is achievable 2MIT: Teaching algae to make fuel 2
(Date:8/1/2014)... York , August 1, 2014 ... Transparency Market Research "Biophotonics Market - Global Industry Analysis, ... the market was valued at USD 25.16 billion in ... by 2020, growing at a CAGR of 10.4% from ... Market Report at  http://www.transparencymarketresearch.com/biophotonics-market.html Increasing demand ...
(Date:8/1/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... AND GLOBAL MARKETS , that the global market RNA ... to nearly $38.8 billion by 2018, with a five-year ... delivery category, the fastest moving segment of the market, ... field of RNAi therapeutics has shown tremendous growth and ...
(Date:8/1/2014)... 2014 Testing the mechanical properties ... better understanding embryonic development. How and why ... and functionally distinct tissues is important because abnormalities ... Todd McDevitt, Melissa Kinney, and Rabbia Saeed worked ... biochemical cues to control many aspects of embryo ...
(Date:7/31/2014)... DENVER , July 31, 2014 Today BioSpace , ... BioMidwest Hotbed map campaign spotlighting the life sciences community in ... , Kansas , Michigan , ... Nebraska , Ohio and Wisconsin ... employment with 11 percent of all job postings on BioSpace originating in ...
Breaking Biology Technology:Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 3Study Links Biomechanics and Gene Expression in Stem Cells 2Midwest Biotech Leaders Featured On BioSpace Map 2
... at the University of Wisconsin-Madison have sucessfully injected stem cells ... treatments for degenerative diseases but they did not use ... stem cells derived from fetal brain tissue into the spinal ... the nervous system. Their findings appeared this week in the ...
... Renaissance Learning Inc., a provider of learning information systems ... net income for the quarter ending March 31 was ... an increase of 8.8 percent. , ,The company also ... payable June 1, 2005, to shareholders of record as ...
... interesting juxtapositions. , ,I spent the morning with Milwaukee entrepreneurs ... the shift from selling services to selling products. The thinking ... Later that day, IBM announced that its year over year ... diver because of a slower than expected shift in the ...
Cached Biology Technology:UW-Madison rat experiment could lead to stem-cell treatment for ALS 2UW-Madison rat experiment could lead to stem-cell treatment for ALS 3UW-Madison rat experiment could lead to stem-cell treatment for ALS 4IBM takes one direction, Milwaukee entrepreneurs the other 2IBM takes one direction, Milwaukee entrepreneurs the other 3
Adhesive seal-tab, for HybriWell™ hybridization sealing system *set of 400*...
...
... choice of PDMS Stamps (3 PDMS micropatterned ... micron squares or 100 um x 10 ... lines, 3 PDMS nano-patterned stamps with depth ... pitch of 400 nm, or 3 PDMS ...
...
Biology Products: