Navigation Links
Could age of first period influence development of diseases in older women?

BOSTONA novel study shows that the age girls reach puberty is influenced by 'imprinted genes'a subset of genes whose activity differs depending on which parent contributes the gene. This is the first evidence that imprinted genes can control the rate of development after birth and details of this study were published today in the journal Nature.

Age of the first period, known as menarche, is a marker for the timing of puberty in females. Medical evidence shows that the onset of menses varies between girls, is an inherited trait, and is linked to breast cancer, diabetes and heart disease risks. "This research is the first step in understanding the genetics involved with the onset of puberty in girls," says Douglas P. Kiel, M.D., M.P.H., Director of the Musculoskeletal Research Center at Harvard Medical Schoolaffiliated Hebrew SeniorLife Institute for Aging Research (IFAR) in Boston, Mass. "By uncovering which genes influence menarche, we can then focus on its link to increased disease risks, such as osteoporosis or diabetes, in later life."

The findings come from an international study of more than 180,000 women involving scientists from 166 institutions around the globe. The researchers identified 123 genetic variations that were associated with the timing of when girls experienced their first menstrual cycle by analyzing the DNA of 182,416 women of European descent from 57 studies. Six of these variants were found to be clustered within imprinted regions of the genome.

The activity of imprinted genes differs depending on which parent the gene is inherited from some genes are only active when inherited from the mother, others are only active when inherited from the father. Both types of imprinted genes were identified as determining puberty timing in girls, indicating a possible biological conflict between the parents over their child's rate of development. Further evidence for the parental imbalance in inheritance patterns was obtained by analyzing the association between these imprinted genes and timing of puberty in a study of over 35,000 women in Iceland, for whom detailed information on their family trees were available.

David Karasik, Ph.D., an associate scientist with Hebrew SeniorLife IFAR who also was involved with the study adds, "The genetics involved in female reproductive maturation is complex. Our findings extend knowledge of genetic influences that could contribute to the development of age-related conditions including menopause and osteoporosis.


Contact: Jennifer Davis
Hebrew SeniorLife Institute for Aging Research

Related biology news :

1. Spinach could lead to alternative energy more powerful than Popeye
2. Danish DNA could be key to happiness
3. Gene discovery could lead to better soybean varieties for Northern United States
4. UEA research reveals how cannabis compound could slow tumour growth
5. Feedback control could be key to robust conservation management
6. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
7. Nanojuice could improve how doctors examine the gut
8. Could boosting brain cells appetites fight disease? New research shows promise
9. Noninvasive advanced image analysis could lead to better patient care
10. Bioelectronics could lead to a new class of medicine
11. Video games could provide venue for exploring sustainability concepts
Post Your Comments:
(Date:10/26/2015)... , October 26, 2015 /PRNewswire/ ... --> adds Biometrics ... to 2021 as well as Emerging ... research reports to its collection of ... . --> ...
(Date:10/23/2015)... DUBLIN , Oct. 23, 2015 Research ... of the "Global Voice Recognition Biometrics Market 2015-2019" ... --> --> The global voice recognition ... during 2014-2019. --> ... 2015-2019, has been prepared based on an in-depth market ...
(Date:10/22/2015)... SYNA ), a leading developer of human interface solutions, today ... --> --> Net revenue ... the comparable quarter last year to $470.0 million. Net income for ... per diluted share. --> --> ... grew 39 percent over the prior year period to $56.9 million, ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... QUEBEC CITY , Nov. 24, 2015 /PRNewswire/ ... (the "Company") announced today that the remaining 11,000 ... Common Share Purchase Warrants (the "Series B Warrants") ... agreement were exercised on November 23, 2015, which ... Common Shares.  After giving effect to the issuance ...
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh ... Insertion points for in-line sensors can represent a weak spot where leaking process ... series of retractable sensor housings , which are designed to tolerate extreme process ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... customer, OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 ... Texas facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds ...
(Date:11/24/2015)... LOS ANGELES , Nov. 24, 2015 ... a biotechnology company focused on the discovery, development and ... Marban , Ph.D., Chief Executive Officer, is scheduled to ... December 1, 2015 at 10:50 a.m. EST, at The ... York City . . ...
Breaking Biology Technology: