Navigation Links
Could age of first period influence development of diseases in older women?
Date:7/25/2014

BOSTONA novel study shows that the age girls reach puberty is influenced by 'imprinted genes'a subset of genes whose activity differs depending on which parent contributes the gene. This is the first evidence that imprinted genes can control the rate of development after birth and details of this study were published today in the journal Nature.

Age of the first period, known as menarche, is a marker for the timing of puberty in females. Medical evidence shows that the onset of menses varies between girls, is an inherited trait, and is linked to breast cancer, diabetes and heart disease risks. "This research is the first step in understanding the genetics involved with the onset of puberty in girls," says Douglas P. Kiel, M.D., M.P.H., Director of the Musculoskeletal Research Center at Harvard Medical Schoolaffiliated Hebrew SeniorLife Institute for Aging Research (IFAR) in Boston, Mass. "By uncovering which genes influence menarche, we can then focus on its link to increased disease risks, such as osteoporosis or diabetes, in later life."

The findings come from an international study of more than 180,000 women involving scientists from 166 institutions around the globe. The researchers identified 123 genetic variations that were associated with the timing of when girls experienced their first menstrual cycle by analyzing the DNA of 182,416 women of European descent from 57 studies. Six of these variants were found to be clustered within imprinted regions of the genome.

The activity of imprinted genes differs depending on which parent the gene is inherited from some genes are only active when inherited from the mother, others are only active when inherited from the father. Both types of imprinted genes were identified as determining puberty timing in girls, indicating a possible biological conflict between the parents over their child's rate of development. Further evidence for the parental imbalance in inheritance patte
'/>"/>

Contact: Jennifer Davis
jdavis@hsl.harvard.edu
617-363-8282
Hebrew SeniorLife Institute for Aging Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Spinach could lead to alternative energy more powerful than Popeye
2. Danish DNA could be key to happiness
3. Gene discovery could lead to better soybean varieties for Northern United States
4. UEA research reveals how cannabis compound could slow tumour growth
5. Feedback control could be key to robust conservation management
6. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
7. Nanojuice could improve how doctors examine the gut
8. Could boosting brain cells appetites fight disease? New research shows promise
9. Noninvasive advanced image analysis could lead to better patient care
10. Bioelectronics could lead to a new class of medicine
11. Video games could provide venue for exploring sustainability concepts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2015)... August 24, 2015 The consulting company ... largest biometrics manufacturer DERMALOG and its customized solutions and products ... Biometrics Company of the Year Award". DERMALOG is particularly successful ... .   -Cross reference: Picture is available at ... On Thursday evening, in South Africa,s ...
(Date:8/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... Alliance and the EMV Migration Forum.  ... Alliance Latin America (SCALA) Chapter provides NXT-ID, Inc. direct ... promoting adoption of smart card technology. To ...
(Date:8/17/2015)... Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market and creator ... campaign for Q4 2015. The new marketing campaign is ... of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ... a leader in retail driven marketing and brand awareness ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... for centuries that copper is a potent weapon against ... serious urinary tract infections "know" this, too, and steal ... them. Blocking this thievery with a drug ... according to researchers at Washington University School of Medicine ...
... Calif.) An evaluation of national data by UC Davis researchers ... higher risk of death. When compared to those with ... risk of death during a follow-up period of six years. People ... if they also had diabetes or hypertension. The findings, ...
... be a breakthrough in the practical application of epigenetic ... that those with osteoarthritis have a signature epigenetic change ... gene that produces a destructive enzyme called MMP13. This ... destruction of joint cartilage, making MMP13 and the epigenetic ...
Cached Biology News:Urinary tract infections steal from hosts' defense arsenals 2UC Davis study finds that above-normal weight alone does not increase the short-term risk of death 2UC Davis study finds that above-normal weight alone does not increase the short-term risk of death 3Scientists discover an epigenetic cause of osteoarthritis 2
(Date:8/31/2015)... and SHANGHAI , Aug. 31, ... company developing next-generation antibiotics, today announced positive top-line ... for its lead drug candidate MRX-I. MRX-I is ... bacteria such as MRSA and VRE, while offering ... therapeutic option than currently available oxazolidinone agents. ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... ... together the world's most successful food and beverage processors, equipment manufacturers and leaders ... in product inspection and industrial weighing and formulation for manufacturers of bakery and ...
(Date:8/28/2015)... August 28, 2015 According to ... Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by Biospecimen ... Clinical Trials), End User - Global Forecast to 2020", ... to reach USD 3,731.03 Million by 2020 from USD ... 11.65% between 2015 and 2020. Browse ...
(Date:8/28/2015)... ... ... launch of FireflySci Inc. (FFS) in early 2015, the company continues to shake up the ... Fonz in a lab coat and Large Marge have been posted on the company’s Facebook ... FireflySci is proud to be the only cuvette manufacturer is the world that has an ...
Breaking Biology Technology:MicuRX Reports Positive Top-Line Results In Phase 2 Clinical Trial For Novel Antibiotic MRX-I In Complicated Skin And Soft Tissue Infections 2METTLER TOLEDO Hosts Food Safety Educational Center at 2015 PROCESS EXPO 2Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2
... Engineering News (Volume 26, No. 11) , , ... one's own shop, even for a period longer than a year, ... filed later to protect the invention. , ,This rule was pronounced ... patent asserted that the patent was invalid due to prior public ...
... Wis. - A new combination of technical solutions ... publishing, broadcasting, and graphic design to transfer high-definition video ... joint solution promises Apple Mac OS X users in ... reduce the time demand for specialized data transfer tasks. ...
... the biotech industry? The July 2006 edition of MedAd News ... birthday this year. On Aug, 23, 2004, I wrote an article ... Boston, Geneva, or Chicago? " , ,In this article I reviewed ... that date the industry back to the 1970s and perhaps the ...
Cached Biology Technology:With patents and research tools, when is private really public? 2With patents and research tools, when is private really public? 3With patents and research tools, when is private really public? 4With patents and research tools, when is private really public? 5Small Tree branches out with affordable video 2At 30, biotech is an industry at a crossroads 2At 30, biotech is an industry at a crossroads 3At 30, biotech is an industry at a crossroads 4At 30, biotech is an industry at a crossroads 5At 30, biotech is an industry at a crossroads 6At 30, biotech is an industry at a crossroads 7
... MOLT-4 cells were cultured in RPMI 1640 with ... phase of growth. In order to keep ... fixed in acetone-methanol. The cells are arrayed ... with each wells surface specifically treated to enhance ...
Cell Culture Flask, 175 cm, tissue-culture treated polystyrene, barcoded...
... Stabilizer is an aqueous solution that contains ... chemicals in a PBS buffer (phosphate buffered ... product contains a combination of 0.02% methylisothiazolone ... StabilCoat Plus Stabilizer provides optimum performance for ...
... clone K28/86.2, PDZ Domain GenBank ... : GST fusion to residues 77-299 ... Tris pH 7.4, 0.075M NaCl containing ... evaluated by immunoblot on rat brain ...
Biology Products: