Navigation Links
'Couch potato pill' might stop heat stroke too
Date:1/8/2012

associated with malignant hyperthermia, a life-threatening inherited disorder of skeletal muscle in which commonly used general anesthetics trigger uncontrolled muscle contractions and dangerous increases in body temperature. Unexpectedly, further work demonstrated that these mice exhibit similar uncontrolled muscle contractions a classic heat stroke response during exposure to high temperatures or when exercising under warm conditions.

The team found that AICAR administration protected the mice from experiencing such contractions under heat stress. If not stopped, the contractions cause muscles to break apart and release their contents, including potassium and proteins, into the blood. High levels of potassium in the blood are extremely toxic and, if not treated quickly, can cause cardiac arrhythmias and death.

Unfortunately, the drug didn't deliver the same positive result for anesthetic-induced malignant hyperthermia.

AICAR made a big splash in 2008 when a study published in Cell, a prestigious scientific journal, found that the drug built muscle and increased endurance in completely inactive mice. As additional studies further established AICAR's ability to improve muscle function, the team grew curious to test how it might influence the whole-body muscle contractions characteristic of RYR1-associated heat stroke in mice.

Not only did they discover the unanticipated protective effect of the drug, but that it worked in a completely different way than they originally thought.

AICAR normally works by activating the body's metabolic "master switch," an enzyme called AMPK that, among other things, influences muscle activity. However, researchers found that the ability of the drug to protect the mice from heat stroke was unrelated to its effects on this master switch. Rather, it directly influenced RYR1.

RYR1, or the type 1 ryanodine receptor, is a protein that plays an essential role in muscle cont
'/>"/>

Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Couch potatoes of the animal kingdom
2. Photos: Turn Your Couch into a Disney Ride for Under $300
3. McMaster researchers find missing genes may separate coach potato from active cousin
4. Biocontrol of sweetpotato weevils
5. New genetic map of potato may lead to improved crops
6. BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research
7. Simple little spud helps scientists crack potatos mighty genome
8. UW-Madison scientists played role in potato genome project
9. Sweetpotato foundation seed tested in commercial operations
10. Not-so-sweet potato from Clemson University, USDA resists pests, disease
11. UC Riverside researcher receives $9 million USDA grant to study potato and tomato disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... A species of gut bacteria called Clostridium ramosum , ... weight. The work is published this week in mBio ... Microbiology. , A research team from the German Institute ... human gut bacteria including C. ramosum gained weight ... C. ramosum were less obese even when consuming ...
(Date:9/29/2014)... September 29: Between 1970 and 2010 populations of ... globe dropped 52 percent, says the 2014 Living ... (WWF). This biodiversity loss occurs disproportionately in low-income ... high-income countries. , In addition to the precipitous ... to other warning signs about the overall health ...
(Date:9/29/2014)... with children at home should use ventilation when cooking ... are recommending, after a new study showed an association ... and chronic bronchitis. , "In homes where a gas ... and wheezing is higher than in homes where a ... an associate professor in the College of Public Health ...
Breaking Biology News(10 mins):Gut bacteria promote obesity in mice 2Half of global wildlife lost, says new WWF report 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... University of Alberta have pinpointed a genetic marker for sporadic ... in Caucasians., Researchers have identified many genetic markers for familial ... for 80 per cent of all cases. Sambasivarao Damaraju, a ... researcher at the Cross Cancer Institute, worked with his team ...
... a novel method of analyzing genetic variations in families, ... genetic variations affecting related biochemical processes may team up ... findings, reported May 28 in Translational Psychiatry , ... and schizophrenia, and may lead to a genetic test ...
... Osteoporosis Foundation,s key regional meeting in Hong Kong ... enriching scientific programme of direct relevance to your ... experts from around the world. http://www.iofbonehealth.org/hongkong-2013/ ... Plenary sessions devoted to epidemiology, ...
Cached Biology News:U of A medical researchers ID genetic marker for sporadic breast cancer 2Family studies suggest rare genetic mutations team up to cause schizophrenia 2
(Date:9/29/2014)... TORONTO , Sept. 29, 2014 /PRNewswire/ - SQI ... company that develops and commercializes proprietary technologies and products ... appointment of Peter Winkley to Chairman of ... Ricks .  Mr. Ricks will continue to serve as ... provide leadership to the Company.  "We ...
(Date:9/29/2014)... CIRENCESTER, England , September 29, 2014 /PRNewswire/ ... tighter margins and greater competition to transform network ... brand   ProLabs , ... infrastructure products, announced today the findings of their ... Optical Communications (ECOC) with top optical communications professionals ...
(Date:9/29/2014)... ZIONA, Israel , September 29, ... stage company developing novel immunomodulators for severe infections, today ... ( BARDA ) has awarded Atox Bio with a ... for the development of AB103 to treat Necrotizing Soft ... and public health threats that end in sepsis. ...
(Date:9/29/2014)... , Sept. 29, 2014 CytRx ... research and development company specializing in oncology, today ... (FDA) has granted multiple Orphan Drug Designations for ... indications: glioblastoma multiforme (GBM), small cell lung cancer ... of the widely-used chemotherapeutic agent, doxorubicin. ...
Breaking Biology Technology:SQI Diagnostics Announces New Chairman of Board of Directors 2End of an Era: OEM Dominance - Could it be a Thing of the Past? 2Atox Bio Awarded Contract Worth up to $24 Million for the Development of AB103 by the Biomedical Advanced Research and Development Authority (BARDA) 2CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 2CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 3CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 4CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 5
... , LANSING, Mich., June 18 Fortune Magazine has ... in its annual list of the "40 best stocks to retire ... 40 list in 2002, stating: "We wanted to assemble a diversified, ... that could soar when the market did but also hold steady ...
... June 18 Environmental Tectonics Corporation,s (OTC Bulletin Board: ... the sale of an additional BARA-MED(R)XD monoplace hyperbaric oxygen ... The state-of-the-art monoplace chamber is among the first ... Oklahoma. , , Hyperbaric chambers are used ...
... FRANCISCO, June 18 Burrill & Company, a San ... Venture Capital, Private Equity, Merchant Banking and Media, is ... firm as Managing Director, Merchant Banking. Shawn will assist ... and capital raising transactions. In addition, Shawn will make ...
Cached Biology Technology:Neogen Named to Fortune's List of 40 Stocks 'To Retire On' 2Environmental Tectonics Corporation Announces Additional Hyperbaric Monoplace Chamber Sale to St. John Wound Center 2Environmental Tectonics Corporation Announces Additional Hyperbaric Monoplace Chamber Sale to St. John Wound Center 3Environmental Tectonics Corporation Announces Additional Hyperbaric Monoplace Chamber Sale to St. John Wound Center 4Shawn Cross Joins Burrill Merchant Banking 2Shawn Cross Joins Burrill Merchant Banking 3
... Disposable. Virgin, optically clear polystyrene ... and alphanumeric coordinates for cell counting. ... number is a new product number, ... number. If showing no availability yet, ...
... The Luminex 100 IS System is a compact ... that integrates lasers, optics, fluidics, a controller, advanced ... This powerful, compact lab analysis system includes the ... Also, it has a DMF file at the ...
... gradient system is ideal for routine binary separations. ... sensitive Adept CE 4201 UV-Visible variable wavelength detector. ... provided by the two highly accurate and ... 4100 solvent delivery pumps., Chromatograms may be plotted ...
... Hep G2 cells were cultured in Minimum Essential ... at the log phase of growth. In ... forms, cells were fixed in acetone-methanol. The ... adhesive coated slide, with each wells surface specifically ...
Biology Products: