Navigation Links
'Couch potato pill' might stop heat stroke too
Date:1/8/2012

We've all seen the story in the news before. Whether it's the death of a physically fit high school athlete at football training camp in August, or of an elderly woman gardening in the middle of the day in July, heat stroke is a serious, life-threatening condition for which there is no treatment beyond submersion in ice water or the application of ice packs to cool the body to a normal temperature.

But, in a new study published today in the journal Nature Medicine, scientists discovered what they believe is one of the first drugs to combat heat stroke. AICAR an experimental therapy once dubbed the "couch potato pill" for its ability to mimic the effects of exercise in sedentary mice protected animals genetically predisposed to the disorder and may hold promise for the treatment of people with enhanced susceptibility to heat-induced sudden death.

"There is a great need for the training staff of athletic teams, physicians in emergency rooms in places like Phoenix, and soldiers serving in the deserts of the Middle East to have a drug available to give to individuals during a heat stroke event," said Robert T. Dirksen, Ph.D., study author and professor of Pharmacology and Physiology at the University of Rochester Medical Center. "Our study takes an important first step towards developing a new drug therapy that may be part of the standard treatment regimen for heat stroke in the future."

The finding comes as heat stroke cases are on the rise. According to a recent study in the American Journal of Preventive Medicine, the number of heat-related injuries in the U.S. more than doubled from 1997 to 2006. In that 10-year period, an estimated 55,000 people were treated for the condition in emergency rooms across the country.

The research team, led by Dirksen's long-time collaborator Susan L. Hamilton, Ph.D., from Baylor College of Medicine, tested the drug in mice with a mutation in the RYR1 gene. The mutation is
'/>"/>

Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Couch potatoes of the animal kingdom
2. Photos: Turn Your Couch into a Disney Ride for Under $300
3. McMaster researchers find missing genes may separate coach potato from active cousin
4. Biocontrol of sweetpotato weevils
5. New genetic map of potato may lead to improved crops
6. BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research
7. Simple little spud helps scientists crack potatos mighty genome
8. UW-Madison scientists played role in potato genome project
9. Sweetpotato foundation seed tested in commercial operations
10. Not-so-sweet potato from Clemson University, USDA resists pests, disease
11. UC Riverside researcher receives $9 million USDA grant to study potato and tomato disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... GOTHENBURG, Sweden , July 2, 2015 ... fingerprint sensors FPC1025, FPC1035, FPC1145 and FPC1155 from the distributor ... is one of FPC,s distributors in Asia ... Q4 2015. The sensors will be used by smartphone manufacturers ... 268 MSEK is included in the communicated revenue guidance of ...
(Date:6/25/2015)... 2015 According to a ... & Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive ... & Others) & Geography - Global Forecast to ... market is expected to reach $14,500.07 Million by ... Browse 76 market Tables and 109 Figures ...
(Date:6/24/2015)... 24, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced that Sharp has selected its industry-leading ... for its latest flagship smartphone device, the AQUOS ... million shipments of its fingerprint ID sensor technology, ... scalability and leadership in the biometrics market through ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... Seattle, Wash. September 4, 2013 A ... identifies a new tool to accurately analyze extremely rare ... diseases and disorders as well as aging. This approach, ... , will help researchers explore mtDNA deletions as potential ...
... 2013) Clay, an abundant and cheap natural material, is ... very high temperatures, according to Rice University researchers who have ... scientist Pulickel Ajayan reported today in Nature,s online journal, ... of up to 200 degrees Celsius (392 degrees Fahrenheit) and ...
... from, the University of York, has discovered five new ... which also included researchers from the Czech University of ... in the Czech Republic, discovered a wealth of unexpected ... expeditions to the Niokolo-Koba National Park in south-eastern Senegal, ...
Cached Biology News:Extremely rare mitochondrial DNA deletions associated with aging can be accurately detected with Droplet Digital PCR 2Extremely rare mitochondrial DNA deletions associated with aging can be accurately detected with Droplet Digital PCR 3Clay key to high-temperature supercapacitors 2Clay key to high-temperature supercapacitors 3
(Date:7/1/2015)... ... 2015 , ... It is now possible to separate two common disorders: post-traumatic ... tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas Jefferson University, and ... is believed to be the largest brain imaging study ever, will be published on ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... The next-generation ... several key market segments, including the molecular diagnostics industry. BCC Research reveals in its ... of NGS-based tests, lower test costs, and a growing need for better diagnostics as ...
(Date:7/1/2015)... HAMILTON, Bermuda , July 1, 2015 /PRNewswire/ ... biopharmaceutical company focused on the treatment of dementia, ... investor briefing on July 22 at 5:45 p.m. ... at the Alzheimer,s Association International Conference 2015 (AAIC). ... following remarks: , Dr. Lawrence ...
(Date:7/1/2015)... InferMed , s ... will augment ... s olutions suite   Elsevier , ... and services, announced today the acquisition of  InferMed , a ... company. InferMed,s Arezzo technology supports clinicians in choosing ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4
... Inc. (Amex:,ADL), developer and marketer of tests for ... announced today that it has conducted the closing,of ... of,2,007,508 shares of common stock and warrants to ... of approximately $5,433,000. The,shares of AMDL common stock ...
... division of Wyeth (NYSE: WYE ), today ... lost profits and other damages,against Teva Pharmaceuticals USA, ... -- a generic version of Wyeth,s PROTONIX(R)., ... the United States,PROTONIX compound patent exclusively licensed to ...
... Calif. -- Every advance in memory storage devices presents a ... into very small spaces. Considering the potential of nanolasers being ... Riverside, things are about to get a lot smaller. ... Khizroev is leading a team exploring lasers so tiny that ...
Cached Biology Technology:AMDL Announces Closing of Private Offering 2Wyeth Will Pursue Claim for Damages Resulting From Teva Pharmaceuticals' Launch of Generic Pantoprazole in Violation of PROTONIX Patent 2Wyeth Will Pursue Claim for Damages Resulting From Teva Pharmaceuticals' Launch of Generic Pantoprazole in Violation of PROTONIX Patent 3Wyeth Will Pursue Claim for Damages Resulting From Teva Pharmaceuticals' Launch of Generic Pantoprazole in Violation of PROTONIX Patent 4The Library of Congress in your wrist watch? 2
Polyclonal Antibody to SHPRH...
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
Mouse Wnt-9b Biotinylated Affinity Purified PAb ENTREZ GeneID: 22412...
Homo sapiens MEP50 protein, mRNA...
Biology Products: