PROVIDENCE, R.I. [Brown University] -- Scientists, health officials, and manufacturers already know that a chemical preservative found in some products, including cosmetics, is harmful to people and animals in high concentrations, but a new Brown University study in tadpoles reports that it can also interrupt neurological development even in very low concentrations.
In the cosmetics industry, the biocide methylisothiazolinone or MIT, is considered safe at concentrations of less than 100 parts per million. Lab studies, however, have found that lower concentrations affected the growth of animal neurons. Picking up from there, the Brown researchers performed a series of experiments to investigate how 10 days of exposure at concentrations as low as 1.5 ppm would affect whole, living tadpoles as they develop. Their results appear in advance online in the journal Neuroscience.
"The lower concentrations we studied didn't kill the animals or cause any big deformities or affect the behavior you'd see just by looking at them," said Carlos Aizenman, associate professor of neuroscience and the study's senior author. "But then we decided to do a series of functional tests and we found that exposure to this compound during a period of development that's critical for the fine wiring of the nervous system disrupted this period of fine tuning."
Aizenman emphasized that there is no evidence in the study that any products with MIT, such as shampoos or cosmetics, are harmful to consumers.
When Aizenman and lead author Ariana Spawn explored the consequences of exposing tadpoles to two nonlethal concentrations, 1.5 ppm and 7.6 ppm, they found some deficits both in behavior and in basic brain development.
In one experiment they shined moving patterns of light into one side of the tadpole tanks from below. As they expected, the unexposed tadpoles avoided the light patterns, swimming to the other
|Contact: David Orenstein|