Navigation Links
Cosmetic chemical hinders brain development in tadpoles
Date:1/10/2012

PROVIDENCE, R.I. [Brown University] -- Scientists, health officials, and manufacturers already know that a chemical preservative found in some products, including cosmetics, is harmful to people and animals in high concentrations, but a new Brown University study in tadpoles reports that it can also interrupt neurological development even in very low concentrations.

In the cosmetics industry, the biocide methylisothiazolinone or MIT, is considered safe at concentrations of less than 100 parts per million. Lab studies, however, have found that lower concentrations affected the growth of animal neurons. Picking up from there, the Brown researchers performed a series of experiments to investigate how 10 days of exposure at concentrations as low as 1.5 ppm would affect whole, living tadpoles as they develop. Their results appear in advance online in the journal Neuroscience.

"The lower concentrations we studied didn't kill the animals or cause any big deformities or affect the behavior you'd see just by looking at them," said Carlos Aizenman, associate professor of neuroscience and the study's senior author. "But then we decided to do a series of functional tests and we found that exposure to this compound during a period of development that's critical for the fine wiring of the nervous system disrupted this period of fine tuning."

Aizenman emphasized that there is no evidence in the study that any products with MIT, such as shampoos or cosmetics, are harmful to consumers.

Neurotoxic effects

When Aizenman and lead author Ariana Spawn explored the consequences of exposing tadpoles to two nonlethal concentrations, 1.5 ppm and 7.6 ppm, they found some deficits both in behavior and in basic brain development.

In one experiment they shined moving patterns of light into one side of the tadpole tanks from below. As they expected, the unexposed tadpoles avoided the light patterns, swimming to the other side. Tadpoles that had been exposed to either concentration of MIT, however, were significantly less likely to avoid the signals.

In another experiment, Aizenman and Spawn, who was an undergraduate at the time and has since graduated, exposed the tadpoles to another chemical known to induce seizures. The tadpoles who were not exposed to MIT and those exposed to the lower concentration each had the same ability to hold off seizures, but the ones who had been exposed to the 7.6 ppm concentration succumbed to the seizures significantly more readily.

In these experiments, seizure susceptibility had nothing to do with epilepsy, Aizenman said, but was instead a measure of more general neural development.

After observing the two significant behavioral effects in the tadpoles, Aizenman and Spawn then sought the underlying physiological difference between exposed and unexposed tadpoles that might cause them. They performed an electrophysiological analysis of each tadpole's optic tectum, a part of the brain responsible for processing visual information. They found evidence that the chemical seems to have stunted the process by which tadpoles prune and refine neural connections, a key developmental step.

"The neural circuits act like the neural circuits of a much more immature tadpole," Aizenman said. "This is consistent with the previous findings in cell cultures."

Aizenman said consumers should know about the study's results and pay attention to the ingredients in the products they use, but should not become worried based on the basic science study.

Aizenman said one area where further studies may be warranted is in cases of repeated exposure in industrial or occupational settings, but the study's broader message may be that chemical manufacturers and independent labs should test more for neurodevelopmental effects of even low concentrations of products. In the specific case of MIT in tadpoles, he noted, "It's resulting in a non-obvious but real deficit in neural function."


'/>"/>
Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Related biology news :

1. Spotlight on cosmetic ingredients conference
2. Exposure of humans to cosmetic UV filters is widespread
3. New woes for silicones in cosmetics and personal care products
4. New device measures viscosity of ketchup and cosmetics
5. Chemical equator discovery will aid pollution mapping
6. Researcher working on destruction of chemical weapons
7. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
8. American Chemical Societys Weekly PressPac -- Sept. 24, 2008
9. A major prize in the chemical sciences announced by the Camille and Henry Dreyfus Foundation
10. American Chemical Societys Weekly PressPac
11. American Chemical Society Weekly PressPac Oct. 15, 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cosmetic chemical hinders brain development in tadpoles
(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/27/2017)... CENTRE, N.Y. , March 27, 2017 /PRNewswire-USNewswire/ ... Healthcare Information and Management Systems Society (HIMSS) Analytics ... Outpatient EMR Adoption Model sm . In addition, ... 12% of U.S. hospitals using an electronic medical ... CHS for its high level of EMR usage ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
Breaking Biology Technology: