Navigation Links
Correcting a trick of the light brings molecules into view
Date:7/14/2010

Conventional wisdom holds that optical microscopy can't be used to "see" something as small as an individual molecule. But as it is wont, clever science has once again overturned conventional wisdom. Secretary of Energy, Nobel laureate and former director of the Lawrence Berkeley National Laboratory (Berkeley Lab) Steven Chu led the development of a technique that enables the use of optical microscopy to image objects or the distance between them with resolutions as small as 0.5 nanometers - one-half of one billionth of a meter, or an order of magnitude smaller than the previous best.

"The ability to get sub-nanometer resolution in biologically relevant aqueous environments has the potential to revolutionize biology, particularly structural biology," says Secretary Chu. "One of the motivations for this work, for example, was to measure distances between proteins that form multi-domain, highly complex structures, such as the protein assembly that forms the human RNA polymerase II system, which initiates DNA transcription."

Secretary Chu is the co-author of a paper now appearing in the journal Nature that describes this research. The paper is titled "Subnanometre single-molecule localization, registration and distance measurements." The other authors are Alexandros Pertsinidis, a post-doctoral researcher and member of Chu's research group at the University of California (UC) Berkeley, who is now an assistant professor at the Sloan-Kettering Institute, and Yunxiang Zhang, a member of Chu's research group at Stanford University.

According to a law of physics known as the "diffraction limit," the smallest image that an optical system can resolve is about half the wavelength of the light used to produce that image. For conventional optics, this corresponds to about 200 nanometers. By comparison, a DNA molecule measures about 2.5 nanometers in width.

While non-optical imaging systems, such as electron microscopes,
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. A*STAR scientists score hat-trick against cancer
2. Rensselaer Polytechnic Institute professor Patrick Underhill receives NSF CAREER award
3. Male antelopes trick females into extra sex opportunities
4. American Society for Microbiology honors Patrick R. Murray
5. Boron-based compounds trick a biomedical protein
6. Chemist receives NIH funding to unravel tricks of neuronal wiring
7. Researcher tricks immune system in diabetic mice
8. Archaeology find sheds new light on family pets
9. Study sheds light on triglyceride metabolism
10. A pinch of light
11. UK geneticists shed light on flowering plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Correcting a trick of the light brings molecules into view
(Date:9/18/2014)... larvae can swim up to 400 kilometres in search of ... environmental change. , Clownfish spend their entire adult lives under ... must wander the open ocean, says study co-author, Dr Hugo ... Studies (Coral CoE) at James Cook University. , "In the ... been given a rare glimpse into how far they can ...
(Date:9/17/2014)... Institute for the Arts and Humanities has received a ... a two-year project, "The Boundaries of the Human in ... will support a wide-ranging series of events aimed at ... One involves artists and researchers who are exploring the ... idea of humanism, and the other involves the increasingly ...
(Date:9/17/2014)... -- "Nature has developed, very cleverly, some lessons on ... optical design," said Joseph Shaw, director of the Optical ... surfaces and structures at the nanoscale, we,ll discover them." ... Diego in August during a conference called "The Nature ... Rongguang Liang of the University of Arizona College of ...
Breaking Biology News(10 mins):Nemo's epic journey to find a new home 2Mellon Foundation awards grant for major project in the humanities and sciences 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3
... by a team of researchers led by Jeffrey Peng, ... of Notre Dame, is using Nuclear Magnetic Resonance (NMR), ... dynamic flexibility of drugs and their targets. The ... American Chemical Society, contributes to the growing attention given ...
... Spanish . , Researchers at the Centre ... the Universidad de Kentucky (USA), have discovered a new way ... pathogen agents responsible for transmissible spongiform encephalopathies or TSEs) by ... control prion disease in deer, which has become an epidemic ...
... Swedish medical university Karolinska Institutet presents a new technique ... the first time. By examining people who had received ... that in all cases there were traces of amphetamine ... tests have been carried out using urine and blood ...
Cached Biology News:Nuclear magnetic resonance aids in drug design 2Researchers embark on work to control the prion epidemic affecting deer in the USA 2Researchers embark on work to control the prion epidemic affecting deer in the USA 3New technique enables drug tests via exhaled breath 2
(Date:9/18/2014)... DUBLIN, Ireland , September 18, ... ,Research and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) ... "Biocompatible Materials - Global Strategic ... offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report ... Materials in US$ Million by the ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... Albumin Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... The report provides a basic overview of the ... The human albumin market analysis is provided for the ...
(Date:9/18/2014)... , Sept. 18, 2014  Neogen Corporation (Nasdaq: ... entered into a strategic agreement with Merck Animal Health ... The Igenity Dairy Heifer Program consists ... information on the genetic potential of replacement dairy heifers. ... calf is born, and is an excellent tool in ...
(Date:9/18/2014)... 18, 2014 SeqLL Inc., the ... technology, announced today the closing of a $1M ... by Genomic Diagnostic Technologies, will increase the power ... , Founded in March 2013 by Daniel Jones, ... at Helicos BioSciences, SeqLL has continued to offer ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2
... , , SAO PAULO , Feb. ... to postpone a decision to reduce Brazil,s ,ethanol import duty from ... to be announced, but not for its impact to take effect once ... it describes as little more than a "bureaucratic" delay. , ...
... , SAN FRANCISCO , ... a leader in Integrated Voice Response (IVR)/Integrated Web Response (IWR) ... allows users to design and deploy clinical trial Integrated Response ... of clinical trials. This time and cost savings stems from ...
... ... nematodes as the Divergence and National Corn Growers Association continues collaboration. , ... (PRWEB) February 9, 2010 -- ... Research (SBIR) grants totaling $500,000, along with renewed funding from the National Corn Growers ...
Cached Biology Technology:Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 2Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 3endpoint Saves Money and Time for Medical Research Teams Through PULSE 2endpoint Saves Money and Time for Medical Research Teams Through PULSE 3New Funding Validates Importance of Divergence's Work on Nematodes 2New Funding Validates Importance of Divergence's Work on Nematodes 3