Navigation Links
Cornell researcher seeks clues to how tuberculosis infects cells
Date:12/21/2007

Cornell researchers are using advanced genetic techniques to better understand the relationship between the bacteria that cause tuberculosis and the human immune system defense cells that engulf them.

The researchers have discovered that unlike many bacterial pathogens, Mycobacterium tuberculosis does not react when immune system cells called macrophages initially make contact; but the bacterium's genes become activated minutes after the pathogen is enveloped by a macrophage and contained in one of its membrane-bound compartments called vacuoles.

David Russell, professor of molecular microbiology at Cornell's College of Veterinary Medicine, and colleagues reported in a November issue of the journal Cell Host and Microbe, that increased acidity inside the vacuoles containing the bacteria serves as the trigger for M. tuberculosis genes to express proteins.

The study also compared the responses of M. tuberculosis to a live bacterial vaccine against tuberculosis known as Bacillus Calmette-Guerin (BCG). It found that the two bacteria may each respond differently to the same stimuli and that BCG appears less capable of protecting itself once inside a macrophage. The findings are consistent with the reduced virulence of BCG, which is key to its safety as a vaccine.

The study is a small part of a larger plan to understand the processes that allow the bacteria to survive within macrophages and then to use that knowledge to develop more effective drugs to fight tuberculosis, which currently kills 2 million people worldwide each year. Existing drugs require six to nine months to treat the active disease that invades and replicates within the lungs.

"What we propose is the exploitation of the data obtained from these basic science studies to develop a comprehensive program of drug development that targets bacterial processes critical to survival inside the human host," said Russell.

Russell's lab used gene chips, or micro
'/>"/>

Contact: Sabina Lee
SSL37@cornell.edu
607-255-3024
Cornell University Communications
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cornell will host the Northeast Biofuel Summit, Nov. 11-13
2. First symposium of UN University-Cornell Africa Series to be held at UN
3. Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots
4. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. Texas researchers and educators head for Antarctica
7. MGH researchers describe new way to identify, evolve novel enzymes
8. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
9. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
10. U of MN researchers discover noninvasive diagnostic tool for brain diseases
11. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... This news release is available in German . ... of chemical signals between organisms is considered the oldest ... social interactions between conspecifics, for example, the sexual attraction ... trigger social responses and to coordinate reproductive behavior in ... at the University of the Algarve in Faro, Portugal, ...
(Date:8/28/2014)... now available from the Lady Bird Johnson Wildflower Center ... harmful non-native plant, insect and other invasive species statewide. ... about $137 billion in economic and other damage annually ... plants and more. , "By having streamlined tools like ... occur, we,re more likely to catch these threats early ...
(Date:8/28/2014)... than traditional cigarettes, but still release toxins into ... USC. , Scientists studying secondhand smoke from e-cigarettes ... harmful particles, with close-to-zero exposure to organic carcinogens. ... in second-hand e-cigarette smoke were found to be ... levels of polycyclic aromatic hydrocarbons cancer-causing organic ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Mobile app makes ID of harmful plants, insects in Texas a snap 2Second-hand e-cig smoke compared to regular cigarette smoke 2
... Advanced Technology Microwave Sounder (ATMS) on board NASA,s newest Earth-observing ... The image shows the ATMS channel 18 data, which measures ... visible in the data, as the patch of blue, in ... The data were processed at the NOAA Satellite Operations Facility ...
... floating weed that clogs waterways around the world has at ... intended for boats and submarines. The Brazilian fern ... in part because its surface is dotted with oddly shaped ... stay afloat. In the November 1 issue of ...
... of African elephants than habitat, and human conflict in particular has ... new University of British Columbia study published online in PLoS ... to date, the study shows the elephant population in the Okapi ... in the Democratic Republic of Congo (DRC) saw a 50 ...
Cached Biology News:NASA'S NPP satellite acquires first ATMS measurements 2Plant with 'eggbeater' testure inspires waterproof coating 2Plant with 'eggbeater' testure inspires waterproof coating 3More than 50 percent decline in elephants in eastern Congo due to human conflict: UBC research 2
(Date:8/31/2014)... Available spectra is similar for all L-series products ... a wide range of plants. The spectra is ... and pending wide spectrum technology. The single chip ... in contrast to growth spectra made from monochromatic ... large variety of differently sized and shaped growing ...
(Date:8/29/2014)... but one of the most promising technologies for future ... light (photons) instead of electrons. First, it is necessary ... photons and control their direction. Researchers around the world ... control, but now scientists at the Niels Bohr Institute ... emitted one at a time and in a particular ...
(Date:8/29/2014)... NY (PRWEB) August 29, 2014 Local ... Hills Veterinary Hospital are seeking candidates to participate in ... with osteoarthritis. The ultimate goal of this study ... stem cells into one or two arthritically affected joints ... joints. , Candidates for the current investigational study ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... Life Technologies Corporation (NASDAQ: LIFE ) ... intention to redeem all of the outstanding 1.5% Convertible ... February 15, 2012. As of December 31, 2011 there ... Convertible Notes outstanding. The redemption notice provided includes CUSIP ...
... has found a way to turn common carbon fiber ... properties expected to prove useful in electronic, optical and ... Pulickel Ajayan, in collaboration with colleagues in China, India, ... chemical process that is markedly simpler than established techniques ...
... PharmaVentures announced today that it was delighted to ... which won Scrip,s ,Outsourcing Deal of the Year 2011,. ... was "one the largest and most comprehensive R&D alliances in ... of the agreement, Sanofi retains access to some of the ...
Cached Biology Technology:Life Technologies Announces Redemption of 1.5% Convertible Senior Notes Due 2024 2Graphene quantum dots: The next big small thing 2Graphene quantum dots: The next big small thing 3PharmaVentures' Client Sanofi Wins Scrip 'Outsourcing Deal of the Year Award' 2
... the cost-effective solution for entry level imaging ... research imaging tasks, MetaVue enables time lapse, ... analysis. Compatibility with MetaMorphs extensive and ... has the power to drive motorized microscopes, ...
Sterile, Cell culture tested...
... Although there have been many modifications to ... defined media, salt solutions still play an important ... to maintain the pH and osmotic balance in ... water and essential inorganic ions, is as valuable ...
A substrate for all AChE-based EIA kits....
Biology Products: