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'Cornell Dots' that light up cancer cells go into clinical trials
Date:1/31/2011

psulated dye to serve as a beacon to identify the target cells. The technology, the researchers say, can show the extent of a tumor's blood vessels, cell death, treatment response and invasive or metastatic spread to lymph nodes and distant organs. The safety and ability to be cleared from the body by the kidneys has been confirmed by studies in mice at MSKCC, reported in the January 2009 issue of the journal Nano Letters (Vol. 9 No. 1).

For the human trials, the dots will be labeled with radioactive iodine, which makes them visible in PET scans to show how many dots are taken up by tumors and where else in the body they go and for how long.

"We do expect it to go to other organs," Bradbury said. "We get numbers, and from that curve derive how much dose each organ gets. And we need to find out how fast it passes through. Are they cleared from the kidney at the same rate as in mice?"

One of many advantages of C dots, Bradbury noted, is that they remain in the body long enough for surgery to be completed. "Surgeons love optical," she said. "They don't need the radioactivity, but [our study] confirms what the optical signal is. As you learn that, eventually you no longer need the radioactivity."

On the other hand, she added, the dots also may serve as a carrier to deliver radioactivity or drugs to tumors. "This is step one to jump-start a process we think will do multiple things with one platform," she said.

First-generation Cornell dots were developed in 2005 by Hooisweng Ow, then a graduate student working with Wiesner. Wiesner, Ow and Kenneth Wang '77 have co-founded the company Hybrid Silica Technologies to commercialize the invention. The dots, Wiesner said, also have possible applications in displays, optical computing, sensors and such microarrays as DNA chips.


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Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University
Source:Eurekalert

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