Navigation Links
Cord blood-derived CD133+ cells improve cardiac function after myocardial infarction
Date:2/3/2010

This release is available in Chinese.

Researchers at the Pontifcia Universidade Catlica do Paran and Instituto Carlos Chagas have evaluated the therapeutic potential of purified and expanded CD133+ cells human umbilical cord blood (HUCB)-derived in treating myocardial infarction by intramyocardially injecting them into a rat model. Patients who have high cardiovascular risks have fewer endothelial progenitor cells (EPCs) and their EPCs exhibit greater in vitro senescence. HUCB-derived EPCs could be an alternative to rescue impaired stem cell function in the sick and elderly. The results, which appear in the January 2010 issue of Experimental Biology and Medicine, show that expanded cells ex vivo exhibited increased expression of mature endothelial cells markers and formed tubule-like structures in vitro. Only the expanded cells expressed VEGF mRNA.

Cells were expanded up to 70-fold during 60 days of culture, and they retained their functional activity. A significant improvement was observed in left ventricular ejection fraction for purified and expanded cells. In summary, CD133+ cells were purified from HUCB, expanded in vitro without losing their biological activity, and both purified and expanded cells showed promising results for use in cellular cardiomyoplasty. However, further pre-clinical testing should be performed to determine whether expanded CD133+ cells have any clinical advantages over purified CD133+ cells.

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "This study suggests that the use of human umbilical cord blood-derived purified and expanded CD133+ cells may show promise for use in cellular cardiomyoplasty. This finding needs subsequent pre-clinical testing but may prove to be very important in future treatments".


'/>"/>

Contact: Dr. Alexandra Senegaglia
alexandra.senegaglia@pucpr.br
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Cells send dirty laundry home to mom
2. Tumor suppressor p53 prevents cancer progression in cells with missegregated chromosomes
3. Disarming specialized stem cells might combat deadly ovarian cancer
4. March of Dimes awards $250,000 prize to scientist who discovered how to reprogram human cells
5. Grant to study how cells sense electric fields
6. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
7. New way to generate abundant functional blood vessel cells from human stem cells discovered
8. Update on pluripotent stem cells (hESC and iPS)
9. Excess DNA damage found in cells of patients with Friedreichs ataxia
10. Mutations in different cells cooperate to set the stage for cancer
11. Study shows that delivering stem cells improves repair of major bone injuries in rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... JOSE, Calif. , Aug. 6, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... TouchPad technologies on Windows 10. Microsoft leveraged Synaptics, ... to the operating system. Through ... drivers are fully certified with Microsoft,s Precision TouchPad ...
(Date:8/5/2015)... The biosensors market is proving highly attractive ... newer sectors, and development of devices resulting in higher ... seen the entry of multiple participants each year with ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) Recent ... Global Biosensors Market ( http://www.frost.com/nee9 ), finds that ...
(Date:8/3/2015)... 2015 Synaptics, Inc. (Nasdaq: SYNA ), ... that members of the executive management team will present ... Technology Leadership Forum on Tuesday, August 11, 2015 at ... at the Sonnenalp Resort in Vail, CO. ... forward-looking information. An audio webcast of the event will ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... An international team of scientists, including botanists from the ... can be used to catalogue the world,s plants using a ... classification method that uses a short genetic marker in an ... species. "Barcoding provides an efficient means by which we ...
... forest burnt by wildfires in the United States is set to ... scientists. The study predicts that the worst affected areas ... Mountains, where the area of forest destroyed by wildfire is predicted ... based on a conservative temperature increase of 1.6 degrees Celsius over ...
... Association for the Advancement of Science,s Pacific Division will convene ... from the Western U.S. to share their work. Marking 150 ... Species, the 90th annual meeting will focus on sustainability in ... Sustainability as a way of life, The changing San Francisco ...
Cached Biology News:University of Toronto helps to 'barcode' the world's plants 2Wildfires set to increase 50 percent by 2050 2
(Date:9/1/2015)... Boston, MA (PRWEB) , ... September 01, 2015 ... ... as its new Director of Business Development, Asia Pacific. In this newly-created position, ... expanding the awareness and use of iLab’s suite of tools. This entails not ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... to bring together supply chain risk management and resiliency practitioners with luminaries and ... share best practices, and be recognized for their innovations and performance excellence. At ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Mexico Biomedical Sensors Market - Growth, Trends & Forecasts ... The Mexico Biomedical Sensors market is estimated at ... over the period 2014-2020 The near future ... genetic formulation of each individual. These sensors can be ...
(Date:8/31/2015)... , Aug. 31, 2015  RXi Pharmaceuticals Corporation ... on discovering and developing innovative therapies primarily in ... that the 30-day review period following the filing ... ocular indications with the U.S. Food and Drug ... now active. Logo -  ...
Breaking Biology Technology:iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3Mexico Biomedical Sensors Market Report 2015-2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4
... regulatory authorities support filing strategy, SEATTLE, Dec. ... CTIC) reported today that it met with and ... marketing,authorization application (MAA) for XYOTAX(TM) (paclitaxel poliglumex,CT-2103). The ... first quarter,of 2008, earlier than the first half ...
... N.Y. - A new biochip technology could eliminate animal ... curtail its use in the development of new pharmaceuticals, ... at Rensselaer Polytechnic Institute, the University of California at ... most recent discovery will be featured in the online ...
... The first hemostasis kit combines two important surgical tools: ... ... 17 Baxter Healthcare,Corporation today announced the Food and ... sponge, USP and human,thrombin). GELFOAM Plus is the only ...
Cached Biology Technology:Cell Therapeutics, Inc. (CTI) to Submit Marketing Authorization Application for XYOTAX(TM) for First-line Non-small Cell Lung Cancer Ahead of Schedule 2Cell Therapeutics, Inc. (CTI) to Submit Marketing Authorization Application for XYOTAX(TM) for First-line Non-small Cell Lung Cancer Ahead of Schedule 3Cell Therapeutics, Inc. (CTI) to Submit Marketing Authorization Application for XYOTAX(TM) for First-line Non-small Cell Lung Cancer Ahead of Schedule 4Biochip mimics the body to reveal toxicity of industrial compounds 2Biochip mimics the body to reveal toxicity of industrial compounds 3Baxter Announces FDA Approval of GELFOAM(R) Plus Hemostasis Kit 2Baxter Announces FDA Approval of GELFOAM(R) Plus Hemostasis Kit 3Baxter Announces FDA Approval of GELFOAM(R) Plus Hemostasis Kit 4