Navigation Links
Cord blood cell transplantation provides improvement for severely brain-injured child
Date:12/22/2010

Tampa, Fla. (Dec. 22, 2010) In three monthly injections, researchers transplanted neurally-committed, autologous cord blood derived cells tagged with iron oxide nanoparticles (SPIO) into the lateral cerebral ventricle of a 16-month old child with severe global hypoxic ischemic brain injury. The study, published in the current issue of Cell Medicine 1(2) and now freely available online at http://www.ingentaconnect.com/content/cog/cm

found through MRI tracking that the primary injected and tagged cells persisted in that brain hemisphere for more than four months. By six months, the severely impaired child showed some slight improvement over a former vegetative state.

"Hypoxic-ischemic encephalopathy remains one of the most devastating conditions in children, resulting in brain atrophy and persistent functional neurological impairment," said Dr. Krystyna Domanska-Janik, corresponding author.

According to Dr. Domanska-Janik, they transplanted cord blood neural cells by repeated injection into lateral cerebral ventricle as the method appeared to be superior to intravascular injections because there would be a more "local modulating outcome."

"The capacity of cells to home to damaged sites in the central nervous system is crucial," said Dr. Domanska-Janik. "Our study found that transplantation of patient self-donor (autologous), neurally-committed cord blood cells is feasible, well tolerated, and safe."

Once more, the transplanted cells were easily assessed by MRI for four months.

"Despite signs of neurological improvement noticed by the parents and neurologists after cell transplantation, this one case does not allow us to predict the true efficacy of such a treatment and further studies are needed," she added.

The research team did suggest that six months post-transplantation, the child's diagnosis of a 'vegetative state' was no longer
'/>"/>

Contact: David Eve
cellmedicinect@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. Malaria-infected cells stiffen, block blood flow
2. Firefly protein lights pathway to improved detection of blood clots
3. CCNY professor gets grant to develop artificial blood
4. Scientists discover new mechanism for controlling blood sugar level
5. HIV drugs interfere with blood sugar, lead to insulin resistance
6. The lifeblood of leaves: Vein networks control plant patterns
7. Nanoengineers aim to grow tissues with functional blood vessels
8. McMaster scientists turn skin into blood
9. UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells
10. X-ray crystallography reveals structure of precursor to blood-clotting protein
11. Listeria clever at finding its way into bloodstream, causing sickness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... is pleased to announce the promotion of Yaniv ... of Digital Forensics. In Schiff,s new role as Director, ... team of digital forensics examiners and provide leadership within ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 Schiff ...
(Date:11/7/2014)... by Dr. Debra Auguste, associate professor, biomedical engineering, ... City College of New York, have identified a ... one of the most aggressive forms of breast ... a high mortality rate owing to aggressive proliferation ... options. However, Professor Auguste,s team, discovered the overexpression ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... have genetic evidence suggesting the antioxidant drugs currently ... the common cold can also help prevent and ... stressa culprit in driving tumor growth. ... loss of the tumor suppressor protein Caveolin-1 (Cav-1) ...
... the increasing incidence of antifungal-resistant infections, according to a ... . The essential oil shows a potent antifungal effect ... nail infections. Scientists from the University of Coimbra ... L,Hr shrub that grows in southern Portugal. The oil ...
... progressive trajectory is one of the most deeply-entrenched assumptions ... popular media by showing cavemen speaking in grunts and ... But is this assumption correct? Were the earliest ... a paper published in the latest issue of ...
Cached Biology News:Jefferson researchers provide genetic evidence that antioxidants can help treat cancer 2Jefferson researchers provide genetic evidence that antioxidants can help treat cancer 3Lavender oil has potent antifungal effect 2Earliest humans not so different from us, research suggests 2Earliest humans not so different from us, research suggests 3
(Date:11/26/2014)... November 25, 2014 Silicon Valley Electronic ... with RPM Alliance , provider of clinical research ... With the latest addition to its CRO Partnership Program, ... EDC system to India. , “We have found ... and customizable EDC platform which is both user friendly ...
(Date:11/26/2014)... Boston, MA (PRWEB) November 26, 2014 ... and collaboration company is proud to announce that Darren ... Development and Sales. Darren will drive the ... and positive customer experience. , Darren brings ... He has held key roles in channel operations, from ...
(Date:11/26/2014)... -- Theravalues Corporation annuncia con orgoglio il lancio di ... Hi Europe 2014 (dal 2 al 4 dicembre, ... curcumina con la maggiore biodisponibilità di sempre, con una ... dalle norme europee. La curcumina è un ... Curcuma longa ) che è stata associata con attività ...
(Date:11/24/2014)... 24, 2014 VolitionRx Limited (OTCQB: VNRX), ... cancer and other conditions, today announced that data from its ... for Business BioWin Day 2014, being held November 26, 2014 ... from VolitionRx,s lung cancer pilot study, the samples for which ... Universitaire (CHU) de Liege in Belgium . ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
... Switzerland, August 19 Arpida Ltd,(SIX: ARPN) announced today its financial results ... Key events 2009 to date, - Regulatory setback for ... under review, - Company restructuring completed, , ... June 2009 , CFO Harry Welten, MBA, commented: ...
... , WESTON, Fla., Aug. 19 In keeping with ... of families, America n Scientific Resources ... obtained from Safeguard Medical Technologies, LLC exclusive worldwide rights to sell ... and the Disintegrator Plus(TM). , , All ...
... , , LONDON, Aug. 19 ... the introduction of improved drugs to treat the disease. As healthcare ... companies conducting research on diabetes vaccines. If they succeed, the entire ... (Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , , ...
Cached Biology Technology:Arpida Reports Interim Results For Six Months to 30 June 2009 2American Scientific Resources To Be Exclusive Seller of World's Only FDA Approved Home Needle Destruction Device 2American Scientific Resources To Be Exclusive Seller of World's Only FDA Approved Home Needle Destruction Device 3Emergence of Newer Drug Classes to Treat Diabetes and Co-morbidities Key to Market Expansion, Reveals Frost & Sullivan 2Emergence of Newer Drug Classes to Treat Diabetes and Co-morbidities Key to Market Expansion, Reveals Frost & Sullivan 3