Navigation Links
Cord blood cell transplantation provides improvement for severely brain-injured child
Date:12/22/2010

Tampa, Fla. (Dec. 22, 2010) In three monthly injections, researchers transplanted neurally-committed, autologous cord blood derived cells tagged with iron oxide nanoparticles (SPIO) into the lateral cerebral ventricle of a 16-month old child with severe global hypoxic ischemic brain injury. The study, published in the current issue of Cell Medicine 1(2) and now freely available online at http://www.ingentaconnect.com/content/cog/cm

found through MRI tracking that the primary injected and tagged cells persisted in that brain hemisphere for more than four months. By six months, the severely impaired child showed some slight improvement over a former vegetative state.

"Hypoxic-ischemic encephalopathy remains one of the most devastating conditions in children, resulting in brain atrophy and persistent functional neurological impairment," said Dr. Krystyna Domanska-Janik, corresponding author.

According to Dr. Domanska-Janik, they transplanted cord blood neural cells by repeated injection into lateral cerebral ventricle as the method appeared to be superior to intravascular injections because there would be a more "local modulating outcome."

"The capacity of cells to home to damaged sites in the central nervous system is crucial," said Dr. Domanska-Janik. "Our study found that transplantation of patient self-donor (autologous), neurally-committed cord blood cells is feasible, well tolerated, and safe."

Once more, the transplanted cells were easily assessed by MRI for four months.

"Despite signs of neurological improvement noticed by the parents and neurologists after cell transplantation, this one case does not allow us to predict the true efficacy of such a treatment and further studies are needed," she added.

The research team did suggest that six months post-transplantation, the child's diagnosis of a 'vegetative state' was no longer justified as the boy began responding to his mother's voice by smiling and a 50 percent reduction in his rate of seizures was achieved.

According to Dr. Paul Sanberg, executive director of the Center of Excellence for Aging and Brain Repair at the University of South Florida, and executive editor of Cell Medicine, this case report is potentially important.

"This first step in the use of autologous stem cells as a treatment for neonatal ischemic brain repair in the clinic provides a guardedly optimistic report for future studies," said Dr. Sanberg. "Of course, further and more comprehensive studies, with a larger patient population, are required to confirm its potential efficacy."


'/>"/>

Contact: David Eve
cellmedicinect@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Malaria-infected cells stiffen, block blood flow
2. Firefly protein lights pathway to improved detection of blood clots
3. CCNY professor gets grant to develop artificial blood
4. Scientists discover new mechanism for controlling blood sugar level
5. HIV drugs interfere with blood sugar, lead to insulin resistance
6. The lifeblood of leaves: Vein networks control plant patterns
7. Nanoengineers aim to grow tissues with functional blood vessels
8. McMaster scientists turn skin into blood
9. UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells
10. X-ray crystallography reveals structure of precursor to blood-clotting protein
11. Listeria clever at finding its way into bloodstream, causing sickness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
(Date:3/18/2016)... -- --> --> Competitive ... Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... security market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which ... defence & security companies in the border security market ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... Morf Media ... compliance training platform on mobile devices, today released a new interactive Food ... Medical Devices. The course is essential for owners or operators of places of ...
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published ... of the state’s 76 fastest-growing private companies; a small percentage of the state's 615,000+ ... organizations on the percent change in revenue from 2012 to 2015. , ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... CEO 2016 on May 31st and June 1st at The Four Seasons Hotel ... executives in the life sciences, offering exclusive access to key decision makers who ...
(Date:5/3/2016)... ... 03, 2016 , ... Flagship Biosciences, the leader in ... Board of Directors. Dr. Gillett recently retired from Charles River Laboratories (CRL), where, ... Scientific Officer. A board-certified veterinary pathologist, Dr. Gillett joined Charles River in 1999 ...
Breaking Biology Technology: