Navigation Links
Coral, human cells linked in death
Date:6/9/2014

genes that coded for not just one TNF receptor, but 40 of them. TNF comes in many different "flavors," and each one matches with a particular receptor. The coral Quistad investigated had 14 different flavors of TNF and more TNF receptors than any other known organism on the planet. Humans, by comparison, have 25 TNF receptors.

So what would happen if you took the human version of a TNF protein and exposed it to a coral's TNF receptors?

Quistad and his colleagues did just that and watched for the telltale signs of apoptosis. Under a microscope, they saw evidence that the coral cell was breaking down within 10 minutes of exposure to human TNF. A series of other cellular signals associated with apoptosis confirmed it: Human TNF sets into motion programmed cell death in corals.

Vice versa?

Next, Quistad and colleagues wondered if coral TNF proteins would trigger apoptosis in human cells. They coaxed E. coli bacteria to express the same TNF proteins produced by corals and exposed them to cultured human tissue. Sure enough, apoptosis occurred in the human cells. Quistad published these results today in the Proceedings of the National Academy of Sciences.

The findings suggest that the pathway by which TNF triggers apoptosis is old. Extremely old.

"The fact that it goes both ways means that these domains haven't changed in half a billion years," Quistad said. "Corals are actually much more similar to humans than we ever realized."

That's interesting from an evolutionary biology perspective, Quistad said, because approximately 542 million years ago, organized life took off in a very big way.

Known as the Cambrian Explosion, this period saw the emergence of the early ancestors of much of the life that exists today, including humans. No one really knows what set off the Cambrian Explosion, but it's possible the evolution of orderly, systematic cell death played a leading role.

"TNF-induce
'/>"/>

Contact: Beth Chee
bchee@mail.sdsu.edu
619-594-4563
San Diego State University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. NOAA reports discovery of table coral, Acropora cytherea, off Oahu
2. No limits to human effects on clouds
3. Study reveals rats show regret, a cognitive behavior once thought to be uniquely human
4. Can mice mimic human breast cancer? MSU study says yes
5. First demonstration in human cells of chromosomal translocations that cause certain cancer
6. Tumor chromosomal translocations reproduced for the first time in human cells
7. Scientists capture most detailed images yet of humans tiny cellular machines
8. Domestication of dogs may explain mammoth kill sites and success of early modern humans
9. Amber discovery indicates Lyme disease is older than human race
10. Virtual Physiological Human Conference 2014
11. Brazilian researchers find human menstrual blood-derived cells feed embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Coral, human cells linked in death
(Date:9/18/2014)... of Americans to undertake jaunts into the countryside each year ... within a century, according to new research. , Climate change ... United States as summer temperatures linger later into the year, ... and Biogeography . For instance, the paper birch a ... Hampshire could change color one to three weeks later ...
(Date:9/18/2014)... is stored in DNA, tiny strands of nucleic acid ... To express this genetic data, our DNA is copied ... proteins that perform tasks in our cells. , ... RNA molecule. Unlike all other known RNAs, this molecule ... molecules are abundant, little has been known about how ...
(Date:9/18/2014)... AZ, Sept. 18, 2014 -- Arizona turned its newborn ... just a few short months, earning it the first-ever Newborn ... The March of Dimes presented Will Humble, M.P.H., Arizona,s Department ... held here today. Mr. Humble established a policy of full ... to send newborn blood samples to the lab for analysis, ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3
... introductory laboratory course at the undergraduate level significantly increases ... mBio , the online open-access journal of the ... Council of Advisors on Science and Technology reported that ... science, technology, engineering and mathematics (STEM) graduates in the ...
... of married couples talking with each other about their health, ... The recordings showed hundreds of couples, ... exercise. Almost all of them were still early in their ... and affectionate, said Thomas Bradbury, a psychology professor in UCLA,s ...
... as pack animals in the biblical stories of Abraham, Joseph, ... domesticated in the Land of Israel until centuries after the ... the Bible,s historicity, this anachronism is direct proof that the ... Now Dr. Erez Ben-Yosef and Dr. Lidar Sapir-Hen of Tel ...
Cached Biology News:Science teaching goes viral 2Are you really going to eat that? 2Are you really going to eat that? 3Finding Israel's first camels 2Finding Israel's first camels 3
(Date:9/19/2014)... 2014 BioTech News Coverage: Progress ... results of studies and trials.  Companies in focus are: ... LLY ), Gilead Sciences Inc. (NASDAQ: ... ) and Arena Pharmaceuticals Inc. (NASDAQ: ARNA) ... therapeutics for the treatment of cancer, announced that the ...
(Date:9/19/2014)... , The first grants awarded ... Endocrinology (ESPE) Meeting  Investment supports innovative projects ... the field of growth  , EMD Serono, ... , today announced the first recipients of the ... were announced during a Satellite Symposium organized by EMD ...
(Date:9/18/2014)... LONDON , Sept. 18, 2014 ... near-patient testing, is performed outside a clinical laboratory. ... hence in administrating appropriate treatments and medication. POCT ... and prevalence of lifestyle diseases such as diabetes, ... and user-friendly. POCT devices are standardized to minimize ...
(Date:9/18/2014)... , September 18, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced ... Materials - Global Strategic Business Report" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the ... US$ Million by the following Product ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3
... Aug. 16, 2011 Regeneron Pharmaceuticals, Inc. (Nasdaq: ... notification from the U.S. Food and Drug Administration (FDA) ... complete the priority review of the EYLEA Biologics License ... degeneration (wet AMD) to November 18, 2011, which is ...
... Aug. 16, 2011 GeoVax Labs, Inc. ... vaccines to prevent and fight Human Immunodeficiency Virus ... million annual notice of award for the Integrated ... HIV/AIDS vaccine program. This grant was ...
... Society of Interventional Radiology Foundation launched a major ... future of the specialty with its announcement that ... conducting preclinical research in interventional radiology during 2012–13 ... Medical Research Fellows Program. (Logo: ...
Cached Biology Technology:Regeneron Announces Review of Biologics License Application for EYLEA™ (aflibercept injection) Extended by Three Months by FDA 2Regeneron Announces Review of Biologics License Application for EYLEA™ (aflibercept injection) Extended by Three Months by FDA 3Regeneron Announces Review of Biologics License Application for EYLEA™ (aflibercept injection) Extended by Three Months by FDA 4GeoVax Awarded $3.6 Million Grant by U.S. Government for its HIV/AIDS Vaccine Program 2GeoVax Awarded $3.6 Million Grant by U.S. Government for its HIV/AIDS Vaccine Program 3Society of Interventional Radiology Foundation Funds Howard Hughes Medical Institute Award 2Society of Interventional Radiology Foundation Funds Howard Hughes Medical Institute Award 3
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
Edited by D. Patel (1994) Comprehensive data on gel electrophoresis of proteins, nucleic acids, nucleoproteins and carbohydrates....
The Protein Kinase Factsbooks (2 Volume Set)...
Biology Products: