Navigation Links
Copy number variation may stem from replication misstep
Date:12/27/2007

Genome rearrangements, resulting in variations in the numbers of copies of genes, occur when the cellular process that copies DNA during cell division stalls and then switches to a different genetic template, said researchers at Baylor College of Medicine in Houston in a report that appears today in the journal Cell.

The new mechanism is called replication Fork Stalling and Template Switching, said Dr. James R. Lupski, Cullen professor of molecular and human genetics and vice chair of the department at BCM. He is also professor of pediatrics. It not only represents a new way in which the genome generates DNA copy number variation, but it also demonstrates that copy number variation can occur at a different time point in the life of a cell. DNA replication takes place as the cell is dividing and becoming two.

Copy number variation involves structural changes in the human genome that result in the deletion or extra copies of genes (or parts of them). Often, this process is associated with disease, and also with evolution of the genome itself.

DNA (deoxyribonucleic acid) exists as two complementary strands that remain together because of the attraction between nucleotides. A or adenosine is always attracted to T (thymidine). C or cytosine is always attracted to G or guanine.

When a cell divides, it must reproduce its DNA so that each cell that results from the division has the same genetic code. That means it must replicate its DNA. During this process, an enzyme called a helicase separates the two strands, breaking the hydrogen bonds between the A T and G C base pairs holding the strands together. The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand (leading strand) of complementary DNA to pair to it. Again, the code is A to T and C to G. This process is continuous. On the other strand that comprises t
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. WCS study finds potential to double tiger numbers in South Asia
2. Technique controls nanoparticle size, makes large numbers
3. Evolution with a restricted number of genes
4. New book presents successful strategies for probing genetic variation
5. Physician-scientists seek solutions to reproductive problems related to chromosomal variations
6. Features of replication suggest viruses have common themes, vulnerabilities
7. DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2009)...ource of more of humanity,s food if steps are take...ing to a study published in the December 2009 issu...ontinues to grow, lack of fresh water and space me...able to meet food demand, according to Carlos M. D...pain, and his seven coauthors. Freshwater aquacult...
(Date:12/5/2009)...ve research into venom produced by snakes and spid...something of a mystery. Now, a study of 158 catfis...MC Evolutionary Biology , has catalogued the prese...cal effects. , Jeremy Wright, from the Univers...n. He said, "I used histological and toxicological...
(Date:12/4/2009)The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest
Breaking Biology News(10 mins):Stem cells battle for space 2Great Expressions Dental Centers Inc Acquires Willow Creek Dental Care in Canton MI 53102 1Great Expressions Dental Centers Inc Acquires Willow Creek Dental Care in Canton MI 53102 2As Medical Bills Contribute to 50 25 of U S Foreclosures CreditFYI Shares 5 Tactics for Managing Medical Debt 53099 1As Medical Bills Contribute to 50 25 of U S Foreclosures CreditFYI Shares 5 Tactics for Managing Medical Debt 53099 2Usability Experts Discuss User Experience in Health IT 53096 1Usability Experts Discuss User Experience in Health IT 53096 2
...8) -- Dr. Kristina M. Johnson, provost and senior ...ns University, recently received the John Fritz Me...ocieties (AAES). She is the first woman so honored...AAES 29th annual awards ceremony in the Great Hall...She was cited for her internationally acknowledged...
...2008 New data show that CAPHOSOL ( www.caphosol.c...ainful oral mucositis (OM) and improves quality of...and radiation therapy. These data will be reporte...ral podium presentation and one tomorrow as a post...ology Nursing Society (ONS). These data confirm th...
...aintaining germ-free homes for their children have...option of anti-bacterial soaps and cleaning agents...oaps now have come under scrutiny by the EPA and F...cerns. , Two closely related antimicrobials, tr... debacle. Whereas triclosan (TCS) has long capture...
Other Biology News:IEEE Fellow first woman to receive highest award in engineering profession 2IEEE Fellow first woman to receive highest award in engineering profession 3IEEE Fellow first woman to receive highest award in engineering profession 4IEEE Fellow first woman to receive highest award in engineering profession 5CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients 2CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients 3CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients 4New study links fate of personal care products to environmental pollution and human health concerns 2New study links fate of personal care products to environmental pollution and human health concerns 3
(Date:12/4/2009)Researchers from the National Institute of Standards and Technology (NIST) and the Naval Research Laboratory have developed a new way to introduce magnetic impurities in a semiconductor crystal by pro
(Date:12/4/2009)CORALVILLE, Iowa, Dec. 4 Vivakor, Inc. (OTC Bulletin Board: VIVK) today confirmed that its shareholders of record on December 1, 2009 will receive the dividend of shares of common stock of HealthAmer
(Date:12/4/2009)Alberta Centre for Advanced Micro Nano Technology Products (ACAMP) hosts, health & medical seminar, , EDMONTON, Dec. 4 /PRNewswire/ - Today ACAMP hosted a health & medical seminar, explaini
(Date:12/4/2009)NEW YORK, Dec. 4 Stemline Therapeutics, Inc. today announced that data from pre-clinical studies of its IL-3R targeting agents, SL-401 and SL-501, in both in vitro and animal models of human chroni
Breaking Biology Technology:NIST researchers put a new spin on atomic musical chairs 2Vivakor Confirms Record Date of Stock Dividend 2Vivakor Confirms Record Date of Stock Dividend 3Alberta companies delivering new products to the health & medical marketplace 2Stemline Therapeutics Announces Poster Presenting in vivo and Anti-Cancer Stem Cell Activity of SL-401 against Chronic Myeloid Leukemia (CML) at the 51st Annual Meeting of the American Society of Hematology (ASH) 2
...RANCISCO, Calif., Oct. 31 Rigel,Pharmaceuticals, ... of,Rigel,s senior management team will host a con...a company update on November 3, 2008 at,5:30 a.m. ...nformation, To access the live call, please dial ...onal) 10 minutes prior to the start time and use t...
...alif., Oct. 31 VNUS(R) Medical,Technologies, Inc....evices,for the minimally invasive treatment of ven...Guido Smeets, MD, as Vice President of Clinical,Re...ns VNUS with over 17 years of clinical experience....ead of Clinical Affairs for,Pelikan Technologies, ...
...E, Md., Oct. 31 OriGene Technologies, Inc.,announ...e available now in,a GFP (green fluorescence prote...and protein expression. With this launch, over 25,...00 mouse ORF clones can be ordered in,pCMV-tGFP ve...chemistry was awarded to the,three scientists who ...
Other Biology Technology:Rigel to Host Update Conference Call 2VNUS Medical Technologies, Inc. Announces the Hiring of Guido Smeets, MD, as Vice President of Clinical Research and Chief Medical Officer 2OriGene Announces 37,000 ORF cDNA Clones in a GFP Vector 2
Mouse Anti-Human OSCAR Monoclonal Antibody, Unconjugated, Clone 259501 from R&D Systems
Rabbit Anti-Human RXRA Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.
Mouse Anti-Human IL-19 Monoclonal Antibody, Unconjugated, Clone 152112 from R&D Systems
...995) This book contains up to date reviews by wo...aetiology and treatment for Alzheimer's disease. S...h greatly improve our understanding of this diseas... clinical and diagnostic aspects, the molecular na...
Biology Products: