Navigation Links
Copy number variation may stem from replication misstep
Date:12/27/2007

Genome rearrangements, resulting in variations in the numbers of copies of genes, occur when the cellular process that copies DNA during cell division stalls and then switches to a different genetic template, said researchers at Baylor College of Medicine in Houston in a report that appears today in the journal Cell.

The new mechanism is called replication Fork Stalling and Template Switching, said Dr. James R. Lupski, Cullen professor of molecular and human genetics and vice chair of the department at BCM. He is also professor of pediatrics. It not only represents a new way in which the genome generates DNA copy number variation, but it also demonstrates that copy number variation can occur at a different time point in the life of a cell. DNA replication takes place as the cell is dividing and becoming two.

Copy number variation involves structural changes in the human genome that result in the deletion or extra copies of genes (or parts of them). Often, this process is associated with disease, and also with evolution of the genome itself.

DNA (deoxyribonucleic acid) exists as two complementary strands that remain together because of the attraction between nucleotides. A or adenosine is always attracted to T (thymidine). C or cytosine is always attracted to G or guanine.

When a cell divides, it must reproduce its DNA so that each cell that results from the division has the same genetic code. That means it must replicate its DNA. During this process, an enzyme called a helicase separates the two strands, breaking the hydrogen bonds between the A T and G C base pairs holding the strands together. The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand (leading strand) of complementary DNA to pair to it. Again, the code is A to T and C to G. This process is continuous. On the other strand that comprises t
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. WCS study finds potential to double tiger numbers in South Asia
2. Technique controls nanoparticle size, makes large numbers
3. Evolution with a restricted number of genes
4. New book presents successful strategies for probing genetic variation
5. Physician-scientists seek solutions to reproductive problems related to chromosomal variations
6. Features of replication suggest viruses have common themes, vulnerabilities
7. DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... the age girls reach puberty is influenced by ,imprinted genes,a ... contributes the gene. This is the first evidence that ... and details of this study were published today in the ... known as menarche, is a marker for the timing of ... of menses varies between girls, is an inherited trait, and ...
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
(Date:7/24/2014)... the use of native animal species for food or ... a significant factor in the decline of many species ... study indicates that more than half of the species ... and hornbills., "By surveying not only the meat made ... eaten inside the forest by hunters and brought to ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2
... SEATTLE Harmit Singh Malik, Ph.D., an evolutionary ... the 2010 Vilcek Prize for Creative Promise in Biomedical ... cash prize, for his research on the co-evolution of ... "immigrant achievement in biomedical science and arts." Malik was ...
... to our understanding of the complex chain of chemistry that ... University of Vermont (UVM), the University of Utah, Vanderbilt University ... demonstrated for the first time the specific activity of the ... integrity of DNA in humans and other mammals. Their work ...
... the sun were easy, we wouldn,t still have the greenhouse ... And while solar energy systems work moderately well in hot ... small percentage of the general energy demand. A new ... source that may be on your dinner plate tonight. ...
Cached Biology News:Dr. Harmit Malik receives Vilcek Prize for creative promise in biomedical science 2Mouse work: New insights on a fundamental DNA repair mechanism 2A new energy source from the common pea 2
(Date:7/25/2014)... of bacteria live in each person,s digestive tract. Scientists ... and stave off harmful infections, but their role in ... shed light on the role of these bacteria, a ... Alm recently tracked fluctuations in the bacterial populations of ... described in the July 25 issue of the journal ...
(Date:7/25/2014)... Albany, New York (PRWEB) July 25, 2014 ... Transparency Market Research, "Biological Drugs Market - Global Industry ... 2020," the global biological drugs market is estimated at ... grow at a CAGR of 10.1% from 2014 to ... million in 2020. , The biological drugs market is ...
(Date:7/25/2014)... July 25, 2014 Lawrence Livermore scientists ... Thomson Reuters list of " The World's Most Influential ... of the 3,000 researchers who were identified by analyzing ... those who published the highest-impact work (2002-2012 and 2012-2013). ... on combustion modeling . , "This recognition is ...
(Date:7/25/2014)... At the request of the AMA, the ... for the public comment period (Docket No. FAA-2014-0396) for ... established by Congress as part of the FAA Modernization ... the new deadline for comments as September 23, 2014. ... published in the Federal Register on July 25, 2014, ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4FAA Grants Comment Extension at the Request of AMA 2
... Blocks of carbon nanotubes can be used to create ... study by researchers at Rensselaer Polytechnic Institute. , Taking ... researchers repeatedly squeezed a 3-millimeter nanotube block and discovered ... pressure sensor. No matter how many times or how ...
... Systems, Inc. (Sparta),the maker of TrackWise(R), and the ... announced that its TrackWise solution has,been chosen by ... development, manufacturing and marketing of specialized products for,critical ... complaint handling,processes. TrackWise provides organizations with a ...
... Human Genome,Sciences, Inc. (Nasdaq: HGSI ) today ... its financial results for the quarter ended,September 30, 2007. ... 1, 2007. (Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO ) The ... will be,held on Thursday, November 1, 2007, at 11:00 ...
Cached Biology Technology:The sensitive side of carbon nanotubes: Creating powerful pressure sensors 2The sensitive side of carbon nanotubes: Creating powerful pressure sensors 3Protherics UK Ltd. Chooses TrackWise for Corrective Action and Preventive Action (CAPA) Management 2Human Genome Sciences To Sponsor Conference Call To Discuss Third Quarter 2007 Financial Results 2
cysteine and glycine-rich protein 2,...
... pan B (B220), 4.5 m, coated ... efficient positive isolation or depletion of ... or lymph node cell suspensions. B220 ... cells and lytically active subsets of ...
Gap junction protein, beta 2, 26kDa (connexin 26) Antigen: Peptide...
NAP-2 (5C7)...
Biology Products: