Navigation Links
Copper's previously unknown exit strategy
Date:7/16/2012

Scientists have long known that the body rids itself of excess copper and various other minerals by collecting them in the liver and excreting them through the liver's bile. However, a new study led by Johns Hopkins researchers and published June 22 in PLoS ONE suggests that when this route is impaired there's another exit route just for copper: A molecule sequesters only that mineral and routes it from the body through urine.

The researchers, led by Svetlana Lutsenko, Ph.D., a professor of physiology at the Johns Hopkins University School of Medicine, found this additional copper escape hatch by studying an animal model of Wilson's disease, a rare disorder most often diagnosed in children. People with this disease accumulate abnormally large amounts of copper in the liver, eventually leading to liver damage and failure.

Micronutrients such as copper, zinc and iron are indispensible for human development. Copper is required for embryonic development, respiration, and cardiovascular function, among other processes; too little copper can be fatal whereas too much can cause neurological impairment and organ failure.

One diagnostic test for Wilson's disease is to check for high amounts of copper in the urine; copper levels could be especially high in advanced stages of this disorder. For decades doctors and scientists have blamed this high urinary copper on the breakdown of cells in the liver, which purportedly dumped their contents into the bloodstream as they died. These contents were thought to be picked up by the kidneys and eventually excreted in the urine.

However, Lutsenko says, this theory had never been tested. To verify this explanation, she and her colleagues examined mice genetically modified to have Wilson's disease. As in people, these animals' liver function gradually worsens over time due to copper accumulation. Eventually the animals' livers regenerate and liver function improves and with this the resear
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. In protein folding, internal friction may play a more significant role than previously thought
2. An economical, effective and biocompatible gene therapy strategy promotes cardiac repair
3. Can you hear me now? New strategy discovered to prevent hearing loss
4. Antitoxin strategy may help target other pathogens
5. President, CEO Leppävuori, VTT: Finland should create a national bioeconomy strategy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... YORK , July 29, 2014  When it comes to ... new devices, if not the last. However, when it comes to ... Though the market for the Internet of Things and its ... make an impact in the healthcare industry, whether it,s in the ... to keep us fit. With that in mind, InformationWeek ...
(Date:7/29/2014)... an easier method to create DNAprotein conjugates. The ... diagnosing diseases. , DNA linked to proteins ... can be used in diagnostic techniques, nanotechnology and ... with DNA can be used for purposes ... biological material. The method also provides easier access ...
(Date:7/29/2014)... (UM SOD) and Medicine (UM SOM) jointly announced ... million grant award from the National Institute of ... Institutes of Health to study the causes, prevention ... which renews a previous $12 million five-year NIAID-funded ... research by studying chlamydial and gonorrheal diseases as ...
Breaking Biology News(10 mins):New method provides researchers with efficient tool for tagging proteins 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4
... work in protein production, a Princeton-led team has discovered ... doing so, they also have discovered how one protein ... cancer-fighting process. In a study appearing in the ... Thomas Silhavy, Princeton,s Warner-Lambert Parke-Davis Professor of Molecular Biology, ...
... Virginia Tech has shown that the oldest complex life ... million years ago likely fed by osmosis. ... the fern-shaped rangeomorphs and the air mattress-shaped erniettomorphs. These ... through their outer membrane, much like modern microscopic bacteria, ...
... under the summer heat, consider this: your child may ... cool old days." To illustrate expected increases in extreme ... projections made with global climate models. Scientific literature ... hot days, "heat waves" (very high temperatures sustained over several ...
Cached Biology News:Princeton team learns why some drugs pack such a punch 2Princeton team learns why some drugs pack such a punch 3Geobiologists propose that the earliest complex organisms fed by absorbing ocean buffet 2Geobiologists propose that the earliest complex organisms fed by absorbing ocean buffet 3Those dog days of August: 3 times the heat by 2050? 2
(Date:7/29/2014)... 2014 G-CON Manufacturing Inc., the standard ... announced a new leadership appointment designed to drive the ... abroad. , Maik Jornitz, Chief Operating Officer of ... charged with leading the pioneering company through its next ... stage of development and look forward to providing our ...
(Date:7/29/2014)... Wendel – recipient of a Regional Top Doctor Award for ... Surgeon Specialists for Nashville, TN – has released a new ... Hydration Booster, Retexturing Night Crème, and Anti-aging C Complex, all ... radiant appearance while protecting them from the sun’s harmful UV ... Dr. J. J. Wendel Plastic Surgery, we have developed a ...
(Date:7/28/2014)... building materials using light, developed by researchers at the ... are often considered the realm of science fiction, such ... cloaked starships won,t be a reality for quite some ... materials with building blocks a few billionths of a ... that light flies through them, and works on large ...
(Date:7/28/2014)... According to a new market research report ... and Joint) Market (By Technology - Stem Cell ... Bone Graft Substitutes, Osteoarticular Diseases, Allogeneic Products, Autogenic ... Share, Growth, Trends and Forecast, 2013 - 2019" ... was valued at USD 2.6 billion in 2012 ...
Breaking Biology Technology:G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2Dr. J. J. Wendel Launches New Line of Skin Care Products 2Building 'invisible' materials with light 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4
... Inc.,(Nasdaq: ENMD ) a clinical-stage pharmaceutical company ... diseases,announced today that James S. Burns, President and ... the ThinkEquity Partners, 5th Annual,Growth Conference, to be ... Francisco,California, September 17-20, 2007. Mr. Burns, presentation is ...
... Sept. 13 VaxGen,Inc. (Pink Sheets: VXGN) today ... to align its cost structure with,its pursuit of ... VaxGen is reducing its workforce from 61 to ... monthly cash expenditures used in operating,activities to $1.4 ...
... COLUMBIA, Md., Sept. 13 Martek Biosciences,Corporation (Nasdaq: ... presenting at the,upcoming UBS Global Life Sciences Conference ... September 24-27, 2007 at the Grand Hyatt in ... on Tuesday, September 25th at,3:00 p.m. Eastern Time. ...
Cached Biology Technology:EntreMed to Present at ThinkEquity Partners' 5th Annual Growth Conference 2VaxGen Further Restructures to Preserve Cash as It Pursues Strategic Initiatives 2
Blot Paper 7 x 8.5cm semi-dry western blots (order number RB-400)...
... rapid and efficient removal of short primers, ... from PCR products (Figure 1). The simple ... Buffer options for fragments >100 bp or ... either single column or 96-well plate format ...
... capped transcripts with the translation boosting Cap ... 100% capped (versus 40% to 80% capped ... about 2 hours. mScript™ also features the ... to be up to 50% more efficient ...
... Baculovirus Expression System with Gateway™ Technology ... plasmids containing the polyhedrin promoter. The ... baculovirus genome (bacmid DNA) by site-specific ... cells. The recombinant bacmid DNA is ...
Biology Products: