Navigation Links
Copper intake makes tumors breathe
Date:11/14/2013

Copper imbalances have been associated with a number of pathological conditions, including cancer. Publishing in PNAS scientists at EPFL have found that copper in drinking water given at the maximum levels permitted in public water supplies accelerated the growth of tumors in mice. On the other hand, reducing copper levels reduced tumor growth. The study strongly suggests that copper is an essential factor for the growth of tumors in humans as well.

Copper is a key player in cell growth. In order to proliferate, cells require energy, which they produce and store in the form of a molecule called ATP. Like all cells, tumor cells produce energy in two different ways: respiration, which requires oxygen, and glycolysis, which does not. Of the two, respiration is the more efficient way to make ATP. However it involves a number of enzymes, and one of the most important ones requires copper for its activity.

In a study led by Douglas Hanahan, researcher at EPFL and holder of the Merck Serono Chair in Oncology, scientists sought to examine the role of copper in cancer. To do this, they used genetically engineered mice with pancreatic neuroendocrine tumors. "This study was motivated by our previous puzzling observation; namely that cancers, unlike healthy tissues, are especially sensitive to changes in systemic copper levels", said Seiko Ishida, the lead author of the paper.

Their research provides direct evidence that copper can enhance the proliferation of cancer cells. "The biggest surprise was that a small amount of copper added to drinking water accelerated the growth of tumors, indicating that copper is an essential nutrient for them, said Ishida.

Teaming up with Johan Auwerx, also at EPFL, the researchers found that copper insufficiency resulted in a lower activity of the respiration enzyme in tumors. PET scans also revealed that copper-deficient tumors took higher levels of glucose, suggesting that their cells were
'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Copper chains: Study reveals Earths deep-seated hold on copper
2. Hybrid copper-gold nanoparticles convert CO2
3. Copper making salmon prone to predators
4. Coppers previously unknown exit strategy
5. Scripps Research Institute scientists show copper facilitates prion disease
6. New study shows how copper restricts the spread of global antibiotic-resistant infections
7. After millennia of mining, copper nowhere near peak
8. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
9. Futuristic copper foam batteries get more bang for the buck
10. Modest alcohol intake associated with less inflammation in patients with common liver disease
11. Red potato chips: Segmentation cues can substantially decrease food intake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Ebola researcher from the University of Texas Medical Branch at ... three monoclonal antibodies can completely protect monkeys against a lethal ... at a time when the disease is severe. , Thomas ... for Nature discussing advances in Ebola treatment research. ... among the most deadly of pathogens, with fatality rates of ...
(Date:8/29/2014)... release is available in German . ... signals between organisms is considered the oldest form of ... between conspecifics, for example, the sexual attraction between males ... responses and to coordinate reproductive behavior in males and ... University of the Algarve in Faro, Portugal, and at ...
(Date:8/29/2014)... Boulder, Colo., USA - The rise of the Tibetan ... on Earth -- is important for both its profound ... In this study published in GSA Bulletin , ... -- "clumped" isotope thermometry -- using modern and fossil ... Zhada basin in southwestern Tibet. , Views range ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... of the School of Chemical Engineering and Analytical Science, has ... announced at the Science, Engineering and Technology Awards in a ... 3rd. The SET Awards are Europe,s most important awards ... for his final year design project detailed design of ...
... to cross-breeding flowers to produce pretty petals or sweet scents ... for producing new types of flowers. DNA analysis of ... of species of the plant could be derived from hybrids ... help explain the rich biodiversity of the natural world, as ...
... a paper published as the cover story of the September ... MIT have demonstrated that graphene, a surprisingly robust planar sheet ... membrane separating two liquid reservoirs. By drilling a tiny ... the graphene membrane, they were able to measure exchange of ...
Cached Biology News:Dyfan is Chemical Engineering Student of the Year 2Nature's gift for gardening may hold key to biodiversity 2Graphene may hold key to speeding up DNA sequencing 2Graphene may hold key to speeding up DNA sequencing 3
(Date:8/28/2014)... MA (PRWEB) August 28, 2014 ... wholesale construction materials, selected SoundConnect to ... their cloud based audio and web conferencing platform ... to support PrimeSource’s employees’ needs. SoundConnect delivers ... , PrimeSource Building Products will be utilizing ...
(Date:8/27/2014)... Varian Medical Systems today broke ground ... Lake City manufacturing facility and allow for the consolidation ... create 1,000 new full time jobs in the state ... home to hardworking people with immense engineering and technical ... success in the manufacturing of our state-of-the-art X-ray technology,” ...
(Date:8/27/2014)... In 2013, Lawrence Livermore National ... Security LLC (LLNS), was awarded more than ... laser system for the European Union's Extreme Light ... the Czech Republic. , When commissioned to its ... " High repetition-rate Advanced Petawatt Laser System " ...
(Date:8/27/2014)... how plants survive impact by the huge amounts ... using this energy for photosynthesis. The hypothesis is ... quickly dissipate the energy throughout the entire protein ... Physics have now managed to successfully ,film, this ... light-absorbing proteins which play a role in photosynthesis ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3DTU researchers film protein quake for the first time 2
... Verenium Corporation (Nasdaq: VRNM ), a ... today announced that it has entered into an agreement ... United States ("Ex-Im Bank") for two 18-month, secured revolving ... These new credit facilities will allow the Company ...
... 2011 PharmaVentures today announced the launch of ... Essential Deal Trends: Oncology 2011 . This new series ... and commercialising new drugs. The first report in the series ... active deal making therapeutic area in the pharmaceutical and biotechnology ...
... cell carcinomas are amongst the most frequent cancers in ... like many other human cancers, contain particular cancer cells, ... potential that sustain tumor growth. Little is known about ... High level of VEGF expression in skin cancer ...
Cached Biology Technology:Verenium Announces Up to $16 Million in New Secured Financings 2Verenium Announces Up to $16 Million in New Secured Financings 3Pfizer, Sanofi and Genentech Feature Prominently in the Oncology Edition of PharmaDeals' New Publication Series; Essential Deal Trends 2Pfizer, Sanofi and Genentech Feature Prominently in the Oncology Edition of PharmaDeals' New Publication Series; Essential Deal Trends 3New role for Vascular Endothelial Growth Factor in regulating skin cancer stem cells 2
... High performance agitation and temperature control ... controls four wells independently and is suitable ... 1.5 L working volume. Its temperature ranges ... . Each well is equipped with an ...
RORgamma (S-14)...
... The RSH-4000 is the only microplate ... It offers long walkaway times with a ... ,Features: , Fully automated with integrated stacker ... Hudsons PlateCrane EX for use in small ...
... provides a comprehensive service for custom ... peptide microarrays synthesized on Paraflo microfluidic ... proteins/antibodies or serum samples. This comprehensive ... designs, binding assays using sample(s) provided ...
Biology Products: