Navigation Links
Copper intake makes tumors breathe
Date:11/14/2013

Copper imbalances have been associated with a number of pathological conditions, including cancer. Publishing in PNAS scientists at EPFL have found that copper in drinking water given at the maximum levels permitted in public water supplies accelerated the growth of tumors in mice. On the other hand, reducing copper levels reduced tumor growth. The study strongly suggests that copper is an essential factor for the growth of tumors in humans as well.

Copper is a key player in cell growth. In order to proliferate, cells require energy, which they produce and store in the form of a molecule called ATP. Like all cells, tumor cells produce energy in two different ways: respiration, which requires oxygen, and glycolysis, which does not. Of the two, respiration is the more efficient way to make ATP. However it involves a number of enzymes, and one of the most important ones requires copper for its activity.

In a study led by Douglas Hanahan, researcher at EPFL and holder of the Merck Serono Chair in Oncology, scientists sought to examine the role of copper in cancer. To do this, they used genetically engineered mice with pancreatic neuroendocrine tumors. "This study was motivated by our previous puzzling observation; namely that cancers, unlike healthy tissues, are especially sensitive to changes in systemic copper levels", said Seiko Ishida, the lead author of the paper.

Their research provides direct evidence that copper can enhance the proliferation of cancer cells. "The biggest surprise was that a small amount of copper added to drinking water accelerated the growth of tumors, indicating that copper is an essential nutrient for them, said Ishida.

Teaming up with Johan Auwerx, also at EPFL, the researchers found that copper insufficiency resulted in a lower activity of the respiration enzyme in tumors. PET scans also revealed that copper-deficient tumors took higher levels of glucose, suggesting that their cells were
'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Copper chains: Study reveals Earths deep-seated hold on copper
2. Hybrid copper-gold nanoparticles convert CO2
3. Copper making salmon prone to predators
4. Coppers previously unknown exit strategy
5. Scripps Research Institute scientists show copper facilitates prion disease
6. New study shows how copper restricts the spread of global antibiotic-resistant infections
7. After millennia of mining, copper nowhere near peak
8. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
9. Futuristic copper foam batteries get more bang for the buck
10. Modest alcohol intake associated with less inflammation in patients with common liver disease
11. Red potato chips: Segmentation cues can substantially decrease food intake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... September 17, 2014 Researchers at UTSouthwestern Medical Center ... circulating protein apolipoprotein E, called apoE3, helps repair the ... apoE4, do not get the benefit of this repair, ... "We believe that we have identified one mechanism by ... a genetic variant, apoE4, is detrimental," said Dr. ...
(Date:9/17/2014)... University] After decades of decline, grasses have returned ... the eye, the marsh in those places seems healthy ... key service of the marsh coastal protection ... the ecosystem function hasn,t come back," said ecologist Mark ... of the study in the journal Biological Conservation ...
(Date:9/17/2014)... the United Kingdom forms a new crime unit designed ... uproar last year over horse meat being passed off ... technique for detecting meat adulteration. They describe their approach, ... ACS, Journal of Agricultural and Food Chemistry . ... is a major global economic problem. But they also ...
Breaking Biology News(10 mins):Protein variant may boost cardiovascular risk by hindering blood vessel repair 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... a common vaginal infection linked to preterm birth appears ... to a University of Pittsburgh School of Medicine study ... Infectious Diseases Society for Obstetrics and Gynecology in Boston. ... risk of preterm birth goes up, said Hyagriv Simhan, ...
... -- The striking differences between humans and chimps arent so much ... but in the way those genes are used, according to new ... the same set of notes being played in very different ways. ... and other primates those involving brains and diet gene ...
... motor in cochlea hair cells dominates the process of ... the cilia atop those cells dominates the response in ... cells in the inner ear amplify sound in mammals ... bouncing cell bodies rather than vibrating, hair-like cilia, according ...
Cached Biology News:Risk of common vaginal infection linked to preterm birth appears higher for blacks 2Gene regulation, not just genes, is what sets humans apart 2Gene regulation, not just genes, is what sets humans apart 3St. Jude study solves mystery of mammalian ears 2St. Jude study solves mystery of mammalian ears 3
(Date:9/18/2014)... September 18, 2014 Pipette.com announces ... Sartorius/Biohit, Socorex, Capp, and AccuPet brand of pipettes. ... 100 uL or less and are a great ... applications. , The micropipette promotions were designed ... economic alternative products to help customers find the ...
(Date:9/17/2014)... 2014 A long-term retrospective study of ... (APBI) via interstitial brachytherapy suggests that women younger ... could be suitable to receive the treatment. Current ... these patients in the "unsuitable" category for APBI. ... meeting, Beaumont Health System,s Peter Y. Chen ...
(Date:9/17/2014)... and PRINCETON, N.J. , ... OTCQB:AEMD), the pioneer in developing targeted therapeutic devices to ... its diagnostic subsidiary, Exosome Sciences, Inc. (ESI), disclosed today ... Exosomes & SingleCell Analysis Summit. On September ... Sciences will give a presentation entitled: "Exosomes: A Multiplexed ...
(Date:9/17/2014)... 17, 2014 JH Technologies ... located in Irvine. JH Technologies, a leader in ... recently announced an expanded partnership with Leica Microsystems into ... and image analysis solutions will be featured at the ... The new showroom facility is located within the JH ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 2Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 4Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3
... Recognition Algorithm Detects and Compensates for ... Irregularities and ... the addition of VeriEye iris recognition technology to the,company,s ... SDK features an advanced iris recognition,algorithm that rapidly detects ...
... Amsterdam,Molecular Therapeutics (Euronext: AMT), a leader in the ... obtained a license from ,TIGET, San,Raffaele Telethon Institute ... to prevent immune responses against gene therapy for ... development of AMT-060,(AMT,s AAV-based gene therapy for this ...
... Oncology-Baylor Charles A.,Sammons Cancer Center, a member of ... Award at the recent 44th American Society of,Clinical ... was one of,only 10 community oncology practices to ... consecutive year that practices affiliated with US,Oncology have ...
Cached Biology Technology:New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems 2New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems 3AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response 2AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response 3Texas Oncology-Baylor Sammons Cancer Center Recognized for Highest Commitment to Clinical Research at ASCO 2
... Normal;heading 1;heading ... types and experimental ... for standard transfection ... transduction systems. ViraPower ...
... Product Rabbit polyclonal to ... conjugated to KLH, corresponding to amino ... / Specificity Cross-reacts with Rat.Expected to ... Mouse (100% identity with immunogen), Rabbit (100% ...
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
... Inventory Racks for cryogenic vials. ... cardboard or stainless steel boxes ... cryo vials. Vapor phase ... Platform risers to be ...
Biology Products: