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Copper folds protein into precursors of Parkinson's plaques
Date:6/14/2011

s them. Only supercomputers like Jaguar, Oak Ridge National Laboratory's most powerful supercomputer the most powerful in the United States, in fact were up to the task. But the simulations finally revealed the binding configuration most likely to result in misfolding.

Their results appear in the June 14 edition of Nature Scientific Reports.

The researchers hope that their finding will advance our understanding of Parkinson's, one of the most common and devastating neurological diseases. "Understanding the molecular mechanism of Parkinson's disease should help researchers in developing drugs that treat the disease rather than merely alleviate symptoms," Bernholc says.


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Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

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