Navigation Links
Coping and copulation behavior may help calculate diabetes risk
Date:11/5/2008

November 6, 2008, Cambridge, UK Discussion of a man's background, attitude, and sexual history isn't just the fodder of Sex and The City episodes in the future, it could also be a way of evaluating his risk of diabetes.

Risk of developing type 2 diabetes and metabolic syndrome is determined by an individual's genetic background. Since this background has in turn been influenced by environment and behavior, it's important to consider these factors when assessing disease risk. While scientists have learned a lot about human disease through research in traditional laboratory mice, there are limits in studying genetic variation since controlled breeding and diet introduces artificially influences.

In order to study diabetes risk in a more naturally genetically diverse animal, Roxanne Oriel, Paul Vrana and colleagues studied glucose tolerance, a test often used to diagnose diabetes and metabolic syndrome, in a type of field mouse native to North America. As reported in their new study published in Disease Models & Mechanisms (DMM), dmm.biologists.org, they specifically chose two species of Peromyscus that are closely genetically related, but differ significantly in their behavioral traits and native environment.

During their tests, they discovered that merely handling the male mice and subjecting them to a placebo test where glucose was replaced with saline resulted in significant differences in blood sugar levels. Males of a calmer, more monogamous species had a higher level of stress hormones and a superior ability to regulate blood sugar, in comparison to males of a less calm, less monogamous species, or females of either species. In combination with studies with male mice bred to have only swapped "male" Y chromosomes, their study shows that a genetic variance linked to the Y chromosome is responsible for the species-specific responses of the males to stress.

Since previous studies of non-human primates by other research groups demonstrates a link between stress hormone levels and monogamy, the UC Irvine group propose that superior stress tolerance and blood sugar regulation is related to monogamy in these mice. Their work not only supports the study of mice with a more natural genetic background, but also points to the importance of considering gene-environment interactions, as well as behavior, when calculating risk of diabetes, metabolic syndrome, and other common diseases.


'/>"/>

Contact: Donna Perry
donna@biologists.com
44-012-234-33319
The Company of Biologists
Source:Eurekalert

Related biology news :

1. City birds better than rural species in coping with human disruption
2. New regulatory mechanism discovered for cell identify and behavior in forming organs
3. Premature children 4 times more likely to have behavioral disorders
4. Complex ocean behavior studied with artificial upwelling
5. Synthetic molecules emulate enzyme behavior for the first time
6. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
7. Its a unisex brain with specific signals that trigger male behavior
8. Amphibians respond behaviorally to impact of clear cutting
9. Research at Argonnes Advanced Photon Source reveals structure and behavior of collagen
10. Accelerometer backpacks aid study of gliding behavior in the flying lemur
11. Prison study to investigate link between diet and behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/29/2016)... RATON, Florida , March 29, 2016 ... or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are ... DNA in ink used in a variety of writing ... theft. Buyers of originally created collectibles from athletes on ... through forensic analysis of the DNA. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... June 23, 2016 ReportsnReports.com ... report to its pharmaceuticals section with historic and ... and much more. Complete report on ... pages, profiling 15 companies and supported with 261 ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global Cell ...
Breaking Biology Technology: