Navigation Links
Conversion of brain tumor cells into blood vessels thwarts treatment efforts
Date:1/24/2011

LA JOLLA, CA--Glioblastoma, the most common and lethal form of brain cancer and the disease that killed Massachusetts Senator Ted Kennedy, resists nearly all treatment efforts, even when attacked simultaneously on several fronts. One explanation can be found in the tumor cells' unexpected flexibility, discovered researchers at the Salk Institute for Biological Studies.

When faced with a life-threatening oxygen shortage, glioblastoma cells can shift gears and morph into blood vessels to ensure the continued supply of nutrients, reports a team led by Inder Verma, Ph.D., in a feature article in this week's issue of the Proceedings of the National Academy of Sciences.

Their study not only explains why cancer treatments that target angiogenesis--the growth of a network of blood vessels that supplies nutrients and oxygen to cancerous tissues--routinely fail in glioblastoma, but the findings may also spur the development of drugs aimed at novel targets.

"This surprising effect of anti-angiogenic therapy with drugs such as Avastin tells us that we have to rethink glioblastoma combination therapy," says senior author Verma, a professor in the Laboratory of Genetics and holder of the Irwin and Joan Jacobs Chair in Exemplary Life Science. "Disrupting the formation of tumor blood vessels is not enough; we also have to prevent the conversion of tumor cells into blood vessels cells."

To grow beyond one to two millimeters in diameter--roughly the size of a pinhead--tumors need their own independent blood supply. To recruit new vasculature from existing blood vessels, many tumors overexpress growth factors, predominantly vascular endothelial growth factor, or VEGF. This led to the development of Avastin, a monoclonal antibody that intercepts VEGF.

"In a recent phase II clinical trial, 60 percent of patients with glioblastoma responded to a combination of Avastin and Irinotecan, which directly interferes with the growth
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Brown University chemists simplify biodiesel conversion
2. Mount Sinai researchers discover new mechanism behind cellular energy conversion
3. New microbial genetic system dissects biomass to biofuel conversion
4. New molecule could save brain cells from neurodegeneration, stroke
5. Reducing diet early in pregnancy stunts fetal brain development
6. New technique to see neurons of the deep brain for months at a time developed at Stanford
7. LCD projector used to control brain and muscles of tiny organisms such as worms
8. Researchers show how Alzheimers plaques lead to loss of nitric oxide in brain
9. New book highlights the cellular and molecular determinants of brain wiring
10. Major advance in MRI allows much faster brain scans
11. UTHealth studies cord blood stem cells for pediatric traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Conversion of brain tumor cells into blood vessels thwarts treatment efforts
(Date:11/7/2014)... 2014  In conjunction with the Glendale ... Community Foundation of the Verdugos has announced the " ... a $250,000 initiative to keep the Verdugo Regional Crime Lab ... six months of existence, the Lab has processed more than ... law enforcement. "Because our number one priority is ...
(Date:11/6/2014)... MD, November 6, 2014 - Insilico Medicine, Inc, ... aging and age related diseases announced a research ... of cancer, Champions Oncology, Inc (OTC: CSBR). , ... for personalized medicine, but Champions Oncology,s TumorGraft technology ... validate the chemotherapy regimen experimentally generating vast amounts ...
(Date:11/4/2014)... amount of death at the right time might actually ... research that could help in understanding animal populations, pest ... a paper in the journal Trends in Ecology ... colleagues conclude that the kind of positive population effect ... or mortality, depends on the size and developmental stage ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2When less is more: Death in moderation boosts population density in nature 2
... proteins and other chemicals that underlies most biological ... that accelerate chemical reactions between molecules. The creation ... synthesis of chemicals and pharmaceuticals, devise new tools ... In the August 16 issue of Nature, ...
... reported in the August issue of Cell Stem Cell, a ... the HIV/AIDS virus leads to learning and memory deficits, a ... surface of the virus not only kills some mature brain ... the birth of new brain cells by crippling adult neural ...
... A mysterious epidemic of thyroid disease among pet ... exposure to dust shed from flame retardants in household ... in a study scheduled for publication the Aug. 15 ... journal from the American Chemical Society, the worlds largest ...
Cached Biology News:MGH researchers describe new way to identify, evolve novel enzymes 2HIV is a 'double hit' to the brain 2Study links cat disease to flame retardants in furniture and to pet food 2Study links cat disease to flame retardants in furniture and to pet food 3
(Date:11/24/2014)... Senior Vice President, General Manager ... skills, business acumen Elsevier , a ... and services, congratulates Diane Bartoli , Senior Vice ... Elsevier Clinical Solutions, for being recognized in the 13 ... issue of Profiles in Diversity Journal ® ...
(Date:11/22/2014)... Boston, MA (PRWEB) November 21, 2014 ... and key investors will gather on December 3rd ... Boston Biotech Conferences series. GeneticRx will take place ... Harvard Medical School and will discuss the present ... gene therapy, exon skipping, and gene editing—as well ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 The ... Analytical, Preparative), by Material (Metal, Glass, Plastic), by ... TLC, SFC] - Forecast to 2018” analyses and ... challenges in North America, Europe, Asia, and Rest ... tables and 15 figures spread through 135 pages ...
(Date:11/21/2014)... LAVAL, Quebec , November 21, 2014 ... KLOX como responsable comercial   Mariano Rodríguez ... finanzas   KLOX está en marcha para ... tratamiento de cura de heridas de reciente aprobación en Europa ... o "la compañía") se complace al anunciar los siguientes nombramientos: ...
Breaking Biology Technology:Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
... match charitable corporate donations with organizations that need them, ... and CEO. , ,The non-profit was begun in 2000 ... a supply-chain software provider. Since then it has crafted ... humanitarian groups. In 2001 Aidmatrix worked with an international ...
... Memorial High in Madison, Wisconsin, won a $20,000 scholarship for ... applications. , ,She took 10th place in the Intel Science ... groups in finite groups." The awards were handed out in ... ,Top prize of $100,000 went to a New York student ...
... As a former attorney and current managing director of ... has tackled his share of challenges. But the tasks ... Public Advisory Committee, for which he recently began serving ... , ,"I have to tell you, it's a very ...
Cached Biology Technology:Online aid group taps former Wisconsin governor McCallum 2Online aid group taps former Wisconsin governor McCallum 3Gulbrandsen tackles 'daunting' challenges in Patent Office 2
Mouse monoclonal antibody raised against a full length recombinant SCGB3A2. NCBI Entrez Gene ID = SCGB3A2...
Mouse monoclonal antibody raised against a partial recombinant QARS. NCBI Entrez Gene ID = QARS...
Mouse polyclonal antibody raised against a partial recombinant QPCT. NCBI Entrez Gene ID = 25797...
Mouse monoclonal antibody raised against a partial recombinant QPCT. NCBI Entrez Gene ID = QPCT...
Biology Products: