Navigation Links
Controlling the triggers of age-related inflammation could extend 'healthspan'
Date:10/21/2013

mprove the healthspan and may also lower healthcare costs as the aging population increases in the U.S."

Dixit and his colleagues investigated the normal aging process of mice that were free of diseases, and fed a normal diet. The research team found that immune sensor Nlrp3 inflammasome is activated in response to aging. They then tested mice to determine if reducing the activity of Nlrp3 inflammasome lowers inflammation, and aging-associated decline in function. Results showed that animals with lower Nlrp3 activation were protected from many age-related disorders such as dementia, bone loss, glucose intolerance, cataracts, and thymus degeneration. Functionally, the mice also performed better, were less frail, and ran for longer durations. The researchers also tested another immune sensor called caspase11, which is activated in response to certain infections, and found that it was not linked to the age-related inflammation process.

"Now that we've identified this mechanism in the Nlrp3 sensor, we might be able to manipulate this immune sensor to delay, or reduce inflammation," Dixit said. "This could lead to the possibility of prolonging healthspan, potentially leading to an old age relatively free of disease or disability."

Dixit said additional studies are needed to explore whether the Nlrp3 mechanism can be safely manipulated without impairing the immune system. He points out that although there are several anti-inflammatory drugs available, none seem to be effective in expanding the healthspan. "One of our long-term goals is to develop therapies or specific diets that could dampen the excessive inflammation process as a means to prevent chronic diseases," he said.


'/>"/>

Contact: Karen Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Controlling genes with light
2. Cell-permeable peptide shows promise for controlling cardiovascular disease
3. White blood cells found to play key role in controlling red blood cell levels
4. New approaches for controlling pesticide exposure in children
5. Discovery of Africa moth species important for agriculture, controlling invasive plants
6. Could chloroplast breakthrough unlock key to controlling fruit ripening in crops?
7. New neural pathway controlling skeletal development discovered
8. Controlling gait of horses may be possible, says key study from Texas A&M
9. Controlling gene expression: How chromatin remodelers block a histone pass
10. Controlling gene expression with hydrogen peroxide switches
11. Controlling inflammatory and immune responses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Controlling the triggers of age-related inflammation could extend 'healthspan'
(Date:9/1/2014)... quality of the U.S. diet showed some modest improvement ... a reduction in the consumption of unhealthy trans fats, ... the rich and the poor. , , An unhealthy ... some cancers. Eating a healthy diet is an important ... Evaluating population trends in diet quality is important because ...
(Date:9/1/2014)... how the alteration of a single nucleotidethe basic building block of ... intellectual disability. The study appears in The Journal of ... caused by a defect in a gene on the X chromosome ... in 230 women and 1 in 360 men carry a so-called ... of the FMR1 gene is slightly longer than normal. ...
(Date:8/31/2014)... University of Warwick have discovered that ,good, cholesterol is ... substance, methylglyoxal - MG, was found to damage ,good, ... from the body. , Low levels of HDL, ... with increased levels of MG being common in the ... , Supported by funding from the British Heart Foundation ...
Breaking Biology News(10 mins):Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3A nucleotide change could initiate fragile X syndrome 2Sugar substance 'kills' good HDL cholesterol, new research finds 2
... for biodiversity often focuses only on the numbers of ... or in the tropics. But what about the ... world, where the species richness of flowering plants and ... and Chilean taxonomists, ecologists, and philosophers explored the worlds ...
... stories of shepherds and travellers encountering lions, for example ... on flocks and people by these fierce predators. Lions ... but for livestock owners around the Waza National Park, ... loss of human life is rarely reported, lion predation ...
... By applying state-of-the-art holographic microscopy to a major ... have identified the swimming and attack patterns of ... kills in the Chesapeake Bay and other waterways. ... online Early Edition of Proceedings of the National ...
Cached Biology News:The conservation lens 2The conservation lens 3Living with lions 2Researchers view swimming tactics of tiny aquatic predators 2Researchers view swimming tactics of tiny aquatic predators 3
(Date:8/29/2014)... A major challenge before new biotechnology ... realm of Boston-Cambridge, is gaining visibility that can lead ... the Director of Boston’s Adult Stem Cell Technology Center, ... visibility of his company an important priority since he ... to a social media marketing campaign launched ...
(Date:8/28/2014)... SAN DIEGO, California, USA (PRWEB) August 28, 2014 ... at the Department of Physics and Optical Science and ... at the University of North Carolina at Charlotte, and ... has been elected to serve as the 2015 Vice ... photonics. , SPIE 2014 President Philip Stahl announced recent ...
(Date:8/28/2014)... Nevada City, Ca. (PRWEB) August 28, 2014 ... an E3 rating for an alcohol-based hand sanitizer, asks ... fall harvest by comparing the hand sanitizer they’re currently ... Sanitizer Spray . Hand hygiene is critical to fighting ... processing environment. Best Sanitizers believes there are key ...
(Date:8/28/2014)... new research platform uses a laser to ... undergoing stress and heating, an approach likely ... microelectronics and batteries., This new technique, called ... heating and the surface stress of microscale ... discussed the merits of surface-stress influence on ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... 7 BioEnergy International, LLC,(BioEnergy), a privately-held, ... and biofuels, announces the,addition of Norman R. ... December,2008. Mr. Augustine has a record of ... of industry and government culminating in his ...
... Vaccine Has Potential to Save Millions of Lives, ... Inc.,(IBT), a biotechnology company focused on development of ... have been awarded a multiyear contract for advanced ... Marburg viruses from the National,Institute of Allergy and ...
... Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: IMDS) a ... today that its distributor,The Oyamo group has place ... (CTLM(R)) for Jerusalem, Israel., (Logo: http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ... import license from the Israel Ministry of,Health which ...
Cached Biology Technology:BioEnergy International, LLC Announces Norman R. Augustine to Join Advisory Board 2BioEnergy International, LLC Announces Norman R. Augustine to Join Advisory Board 3Integrated BioTherapeutics Awarded NIAID Contract For Up to $65 Million for Development of a Vaccine against Ebola and Marburg Viruses 2Integrated BioTherapeutics Awarded NIAID Contract For Up to $65 Million for Development of a Vaccine against Ebola and Marburg Viruses 3Imaging Diagnostic Systems Receives its First Order for its CT Laser Mammography System for Israel 2
... Avidin is chromatographically purified from egg white. The ... 15.5.The product is in 10 mM phosphate-buffered ... serum albumin, 0.05% sodium azide and 50% glycerol. ... The conjugate is purified by molecular sieving ...
... The Zero Blunt TOPO ... Sequencing is designed for ... of blunt-end PCR products. ... 5-minute TOPO Cloning and ...
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
Biology Products: