Navigation Links
Controlling inflammatory and immune responses
Date:7/12/2012

Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell.

IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce inflammation. They are used in medicine to treat diseases such as allergies, asthma, and autoimmune diseases.

"In molecular biology and genetics, proteins known as transcription factors bind to DNA in order to control the expression (or transcription) of genetic information," explains Dr. Drouin, Director of the Molecular Genetics research unit at the IRCM. "Our work defined the genome-wide interaction between two transcription factors: Stat3 and the glucocorticoid receptor (GR)."

While Stat3 acts on pro-inflammatory gene targets, glucocorticoids are widely used for their anti-inflammatory properties and their receptor, GR, interacts with Stat3 to control these actions. GR can be found in almost every cell in the body and regulates genes that control development, metabolism, and inflammatory and immune response.

Transcription factors can control the flow of information alone or along with other proteins, either by promoting (as an activator) or blocking (as a repressor) the recruitment of enzymes required for the expression of specific genes. Transcription factors can bind directly to DNA or attach themselves to another DNA-bound protein.

"In some cases, the proteins will behave differently depending on how they are connected to a DNA sequence," says David Langlais, former doctoral student in Dr. Drouin's laboratory and first author of the article. "We were interested in understanding why some transcription factors could act as activators when bound directly to DNA, but act as repressors if they are recruited by another protein. The molecular basis for this dual action remained unclear until now."

Jacques Drouin's research is funded by the Canadian Institutes for Health Research (CIHR). Catherine Couture and Aurlio Balsalobre, both researchers in Dr. Drouin's laboratory, also contributed to this research project.


'/>"/>
Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Researchers say tart cherries have the highest anti-inflammatory content of any food
2. Scientists discover new inflammatory target
3. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
4. BUSM researchers identify key regulator of inflammatory response
5. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
6. TLR1 protein drives immune response to certain food-borne illness in mice
7. Researchers discover molecule in immune system that could help treat dangerous skin cancer
8. Innate immune system protein provides a new target in war against bacterial infections
9. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
10. Preventing the immune system from going haywire during sepsis
11. Programmable DNA scissors found for bacterial immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... --> --> ... Recognition Market by Technology (Pattern Recognition), by Component (Hardware, ... Type (On-Premises and Cloud), by Industry Vertical and by ... the global market is expected to grow from USD ... 2020, at a CAGR of 19.1%. , ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® , ... enrollment solutions, today announced the addition of smart ... Altus multi-factor authentication platform. New contextual and ... to step-up security where it,s needed most — ... Washington, DC . --> ...
(Date:3/2/2016)... 2016 http://www.researchandmarkets.com/research/wzwqtz/global_biometrics ... the  "Global Biometrics Market in Hospitality Sector ... http://photos.prnewswire.com/prnh/20130307/600769) , , Global biometrics market in ... CAGR of around 27%   --> ... the addition of the  "Global Biometrics Market ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... During a two day program ... viable company, CereScan’s CEO, John Kelley, joined other Denver business leaders in providing ... in the Denver area business community, shared his top fundamental learnings in building ...
(Date:4/28/2016)... The report "Cryocooler Market by ... (Technical Support, Product Repairs & Refurbishment, Preventive Maintenance, and ... 2022", published by MarketsandMarkets, the global market is expected ... a CAGR of 7.29% between 2016 and 2022. ... Figures spread through 159 Pages and in-depth TOC on ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... made significant investments in recruiting top industry experts, and expanding its LATAM network ... provides industry-leading tools for clients to manage their clinical trial projects. , The ...
(Date:4/27/2016)... ... , ... The Pittcon Organizing Committee is pleased to announce that Charles “Chuck” ... of Committee since 1987. Since then, he has served in a number of key ... for both the program and exposition committees. In his professional career, Dr. Gardner is ...
Breaking Biology Technology: