Navigation Links
Controlling inflammatory and immune responses
Date:7/12/2012

Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell.

IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce inflammation. They are used in medicine to treat diseases such as allergies, asthma, and autoimmune diseases.

"In molecular biology and genetics, proteins known as transcription factors bind to DNA in order to control the expression (or transcription) of genetic information," explains Dr. Drouin, Director of the Molecular Genetics research unit at the IRCM. "Our work defined the genome-wide interaction between two transcription factors: Stat3 and the glucocorticoid receptor (GR)."

While Stat3 acts on pro-inflammatory gene targets, glucocorticoids are widely used for their anti-inflammatory properties and their receptor, GR, interacts with Stat3 to control these actions. GR can be found in almost every cell in the body and regulates genes that control development, metabolism, and inflammatory and immune response.

Transcription factors can control the flow of information alone or along with other proteins, either by promoting (as an activator) or blocking (as a repressor) the recruitment of enzymes required for the expression of specific genes. Transcription factors can bind directly to DNA or attach themselves to another DNA-bound protein.

"In some cases, the proteins will behave differently depending on how they are connected to a DNA sequence," says David Langlais, former doctoral student in Dr. Drouin's laboratory and first author of the article. "We were interested in understanding why some transcription factors could act as activators when bound directly to DNA, but act as repressors if they are recruited by another protein. The m
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers say tart cherries have the highest anti-inflammatory content of any food
2. Scientists discover new inflammatory target
3. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
4. BUSM researchers identify key regulator of inflammatory response
5. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
6. TLR1 protein drives immune response to certain food-borne illness in mice
7. Researchers discover molecule in immune system that could help treat dangerous skin cancer
8. Innate immune system protein provides a new target in war against bacterial infections
9. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
10. Preventing the immune system from going haywire during sepsis
11. Programmable DNA scissors found for bacterial immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... last decade in Taiyuan, China, have substantially improved the ... than 50% reduction in costs associated with loss of ... researchers at the Columbia Center for Children,s Environmental Health ... Shanxi Medical University, the Center of Diseases Control and ... of Public Health. , The study is the first ...
(Date:9/2/2014)... others are done in by it. New research at ... so-called stress gap in mice with very similar genetic ... better understand the development of psychiatric disorders such as ... unique experiences as it goes through its life. And ... expression of genes, and as a result, affect an ...
(Date:9/1/2014)... that corals whose calcium-carbonate skeletons form the ... that rely entirely on ocean currents to deliver ... now scientists at MIT and the Weizmann Institute ... they are far from passive, engineering their environment ... enhance their ability to exchange nutrients and dissolved ...
Breaking Biology News(10 mins):Clean air halves health costs in Chinese city 2Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3Nature's tiny engineers 2Nature's tiny engineers 3
... about how the human gut helps regulate our appetite have ... Scientists at the University of Cambridge are using the fruit ... pregnant women suffer from bloating and constipation, and even the ... scientists have known for some time that there are as ...
... MarylandThe American Association of Anatomist,s (AAA) will present its ... already made important contributions in their respective fields and ... will present an awards lecture at the AAA Annual ... 5-7 p.m., Walter E. Washington Convention Center, Washington, DC, ...
... This release is available in German . ... consumption is rising dramatically. Indeed, worldwide consumption of red meat ... Organization (FAO) expects increasing prosperity to lead to a doubling ... is whether our planet, with its limited farmland resources, will ...
Cached Biology News:Pregnant, constipated and bloated? Fly poo may tell you why 2Pregnant, constipated and bloated? Fly poo may tell you why 3American Association of Anatomists announces young investigator award winners 2Eating low-fat, thanks to lupin proteins 2
(Date:9/2/2014)... , Sept. 2, 2014  Spherix Incorporated (SPEX) -- an ... monetization of intellectual property, today announced that the United ... to the Company in the month of August that ... The issued patents are: ... U.S.RE45,081 issued August 19, 2014; and , U.S.RE45,095 ...
(Date:9/1/2014)... Reportlinker.com announces that a new market ... India Solid Waste Management Vehicles Market Forecast ... In India ... responsible for complete handling and regulation of solid ... 135,000 MT solid waste is generated daily in ...
(Date:8/31/2014)... , Aug. 31, 2014 Wockhardt Limited ... Discovery program in Anti-Infective research when two of its ... Qualified Infectious Disease Product (QIDP) status from U.S. Food ... drugs which act against pathogens which have a high ... identified by Centre for Disease Control (a top U.S. ...
(Date:8/31/2014)... 31, 2014 This is a ... of the Epoxy Hardener industry in Global ... of the industry, including definitions, applications and industry ... market analysis are provided with a focus on ... market. A comparison between the international and Chinese ...
Breaking Biology Technology:United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... KOSN ) announced today that Gary S. Titus, ... at the 2007,UBS Global Life Sciences Conference in New ... at 10:00 a.m. EST. Interested parties may access ... Calendar" page under the "Investors/Press" tab on,Kosan,s website at ...
... SHENYANG, China, Sept. 18 /Xinhua-PRNewswire-FirstCall/ -- 3SBio ... biotechnology company focused on,researching, developing, manufacturing and ... General Meeting of Shareholders,of 3SBio Inc. will ... Wednesday, October 17,2007 at Tower B-13, Grand ...
... Biodel Inc. (Nasdaq:,BIOD) today announced additional clinical ... Scientific Sessions of the European Association for ... II meal study data was disclosed in ... pharmacodynamics of,insulin VIAject(TM), insulin lispro and regular ...
Cached Biology Technology:Kosan Biosciences to Present at the 2007 UBS Global Life Sciences Conference 2Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting 2Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting 3
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Human peripheral blood CD56+ NK cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
...
Biology Products: