Navigation Links
Controlling for size may also prevent cancer
Date:9/20/2007

Scientists at Johns Hopkins recently discovered that a chemical chain reaction that controls organ size in animals ranging from insects to humans could mean the difference between normal growth and cancer. The study, published in the Sept. 21 issue of Cell, describes how organs can grow uncontrollably huge and become cancerous when this chain reaction is perturbed.

This chain reaction, a domino-like chain of events we call the Hippo pathway, adds a single chemical group on a protein nicknamed Yap, says lead author Duojia Pan, Ph.D., associate professor of molecular biology and genetics. The good news is that maybe all organ growth can be reduced to this one chemical event on the Yap protein but the better news is that we potentially have a new target for cancer therapy.

Pan and colleagues previously had discovered in fruit flies that too much Yap supercharges growth-inducing genes and causes organs to overgrow.

In the new study designed to see if the same effect occurred in mammals, the research team genetically altered mice to make high levels of Yap protein, but only in liver cells. These animals livers grew to be five times the size of a normal mouse liver and often were dotted with large tumors.

We were totally amazed, says Pan. Five times is just a huge effect. When the researchers next looked at a variety of human cancer cells, they found that 20 percent to 30 percent contained increased levels of Yap. We think it might be the extra Yap in these cells contributing to their cancerous growth, says Pan.

Yap, like most proteins, exists in more than one form, in this case two, one with and one without a chemical phosphate tag attached. Such tags can dramatically alter what proteins do in the body.

When the Hopkins team engineered the cells to stop or slow growth, Yap in those cells has its phosphate attached and moves from the nucleusthe brain center of the cellinto the main body of cells, or cytoplasm.

A drug that somehow turns off Yap might also stop cancer cells from growing, says Pan, and manipulating the Hippo pathway could provide a way to grow organs to a pre-determined size for transplantation.


'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Related biology news :

1. Controlling protein diversity
2. Scientists find that protein controls aging by controlling insulin
3. Gene controlling circadian rhythms linked to drug addiction
4. Enzyme affects hypertension by controlling salt levels in body
5. Controlling wildlife trade key to preventing health crises, study says
6. Liquid crystals show promise in controlling embryonic stem cells
7. Important gene controlling tree growth and development found
8. Key gene controlling eye lens development identified
9. Electronic chip, interacting with the brain, modifies pathways for controlling movement
10. Edge density key to controlling gypsy moth spread
11. Key gene controlling kidney development found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 2017 Research and Markets has announced the ... to their offering. ... eye tracking market to grow at a CAGR of 30.37% during ... Market 2017-2021, has been prepared based on an in-depth market analysis ... and its growth prospects over the coming years. The report also ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Eli Lilly and Company ... data evaluating galcanezumab for the prevention of migraine at ... will take place April 22-28, 2017, in ... four abstracts at AAN, including safety and patient outcomes ... associated with a reduction in monthly migraine headache days ...
(Date:4/20/2017)... , ... April 20, 2017 , ... ... sources for advanced technology applications, announced today that Chief Executive Officer (CEO) Debbie ... SEMI is the global industry association connecting the electronics manufacturing supply ...
(Date:4/20/2017)... , April 20, 2017 For ... focuses on novel drug development and clinical research aimed at ... Biostage Inc. (NASDAQ: BSTG), Keryx Biopharmaceuticals Inc. (NASDAQ: KERX), Kite ... ZIOP ). You can access our complimentary research reports ... ...
(Date:4/19/2017)... ... April 19, 2017 , ... Nobilis Therapeutics Announces Completion of Landmark ... Clinical Data in its Upcoming Post Traumatic Stress Disorder Trial , Nobilis Therapeutics, ... trial assessing efficacy of its NBTX-001, a xenon-based therapeutic in the treatment of Panic ...
Breaking Biology Technology: