Navigation Links
Controlling for size may also prevent cancer
Date:9/20/2007

Scientists at Johns Hopkins recently discovered that a chemical chain reaction that controls organ size in animals ranging from insects to humans could mean the difference between normal growth and cancer. The study, published in the Sept. 21 issue of Cell, describes how organs can grow uncontrollably huge and become cancerous when this chain reaction is perturbed.

This chain reaction, a domino-like chain of events we call the Hippo pathway, adds a single chemical group on a protein nicknamed Yap, says lead author Duojia Pan, Ph.D., associate professor of molecular biology and genetics. The good news is that maybe all organ growth can be reduced to this one chemical event on the Yap protein but the better news is that we potentially have a new target for cancer therapy.

Pan and colleagues previously had discovered in fruit flies that too much Yap supercharges growth-inducing genes and causes organs to overgrow.

In the new study designed to see if the same effect occurred in mammals, the research team genetically altered mice to make high levels of Yap protein, but only in liver cells. These animals livers grew to be five times the size of a normal mouse liver and often were dotted with large tumors.

We were totally amazed, says Pan. Five times is just a huge effect. When the researchers next looked at a variety of human cancer cells, they found that 20 percent to 30 percent contained increased levels of Yap. We think it might be the extra Yap in these cells contributing to their cancerous growth, says Pan.

Yap, like most proteins, exists in more than one form, in this case two, one with and one without a chemical phosphate tag attached. Such tags can dramatically alter what proteins do in the body.

When the Hopkins team engineered the cells to stop or slow growth, Yap in those cells has its phosphate attached and moves from the nucleusthe brain center of the cellinto the main body of cells, or cytoplasm.

A drug that somehow turns off Yap might also stop cancer cells from growing, says Pan, and manipulating the Hippo pathway could provide a way to grow organs to a pre-determined size for transplantation.


'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Related biology news :

1. Controlling protein diversity
2. Scientists find that protein controls aging by controlling insulin
3. Gene controlling circadian rhythms linked to drug addiction
4. Enzyme affects hypertension by controlling salt levels in body
5. Controlling wildlife trade key to preventing health crises, study says
6. Liquid crystals show promise in controlling embryonic stem cells
7. Important gene controlling tree growth and development found
8. Key gene controlling eye lens development identified
9. Electronic chip, interacting with the brain, modifies pathways for controlling movement
10. Edge density key to controlling gypsy moth spread
11. Key gene controlling kidney development found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... 12, 2017 A new report by Allied Market Research, titled, ... biometric technology market is expected to generate revenue of $10.72 billion by 2022, with ... Continue Reading ... Allied Market Research Logo ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) In the ...
(Date:1/6/2017)...  SomaLogic announced today that it has agreed ... iCarbonX, the China -based company ... Health Ecosystem that can define each person,s ,digital ... behavioral and psychological data, the Internet and artificial ... will provide proteomics data and applications expertise to ...
(Date:1/3/2017)... 2017 Onitor, provider of digital health technology ... an innovative biometric data-driven program designed to aid weight ... the 2017 Consumer Electronics Show (CES) in ... U.S., the World Health Organization (WHO), have identified lifestyle ... who are overweight or obese. WHO also states that ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), Livestock ... Global Forecast to 2022", published by MarketsandMarkets, the global market is estimated to ... 1,399.6 Million by 2022, at a CAGR of 6.96% from 2016. ... ... MarketsandMarkets Logo ...
(Date:1/11/2017)... Los Angeles, California (PRWEB) , ... January 11, ... ... collaborative approach to support fertility specialists with accurate and reliable preimplantation genetic screening ... and we have achieved excellent results,” says Ovation Fertility Genetics Scientific Director ...
(Date:1/11/2017)... NEW YORK , Jan. 11, 2017  Brian ... surgeon, and founder of Blue Horizon International (BHI), will ... in Davos from January 17-20, ... the global conference. The theme of this ... of the program,s 400 sessions will address strategies for ...
(Date:1/11/2017)... San Francisco, CA (PRWEB) , ... January 11, ... ... ongoing series of in-kind scientific grants to ground-breaking microbiome studies. Its most recent ... University School of Medicine, who will study the effect of long-term use of ...
Breaking Biology Technology: