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Controlling embryonic fate by association
Date:5/4/2008

Then we need to identify the individual parts and ask the big question: How do different parts work together and why do you need special parts"

We noticed that there are many histone deacetylases, he said. Nanog uses these proteins to control gene expression and maybe also the chromatin state. When there is deacetylation, the gene is in a passive state.

The embryonic stem cell is always at the stage of deciding whether to divide (and make more embryonic stem cells) or to differentiate, Songyang said. All the extrinsic and intrinsic signals make the life of the embryonic stem cell transient. In other words, it has to be ready to go down either road.

It becomes an interesting question, said Songyang. Such a demanding state of readiness may mean that the embryonic stem cell requires a different complex at the chromatin than the somatic (or differentiated cell).


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Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

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