Navigation Links
Controlling embryonic fate by association
Date:5/4/2008

Association determines fate in embryonic stem cells, said Baylor College of Medicine researchers in a report that appears in the current issue of the journal Nature Cell Biology.

These findings provide models of how the embryonic stem cell is maintained in its flexible state, said Dr. Zhou Songyang, professor of biochemistry and molecular biology at BCM and senior author of the report. It provides another hint as to how gene transcription is controlled in embryonic stem cells.

One aim of embryonic stem cell research is to understand how the cells determine whether they will keep dividing and maintain a pool of embryonic cells, or start the process of cellular differentiation that results in different cell types.

Songyang and his colleagues found that two critical embryonic cell proteins Nanog and Oct4 associate with specific components that are parts of transcription repression complexes. These complexes affect the way that genes are expressed and carry out their tasks in the cell.

A special complex called NODE (Nanog and Oct4-associated Deacetylase) contains a critical component called Mta1 along with histone deacetylases. NODE associates with Nanog and Oct4 to control the fate of embryonic stem cells, said Songyang.

Histones are critical parts of genomic DNA structures or chromatins, acting as spools around which the genetic material winds in the nucleus. The DNA wraps more tightly when deacetylase removes the acetyl tails from the histones. The tight wrapping makes it hard for genes to be transcribed into the message that allows them to carry out their roles in the cell.

Think of it as the parts of a car, said Songyang. If you think of Nanog as the engine that drives it, you realize that the car still needs accessories like wheels, the tailpipe, etc. We are interested in the big machinery of which proteins (like Nanog) are the drivers. We want to understand the enzymatic activities of the complexes.
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Controlling a sea of information
2. Controlling schistosomiasis: buffalo or snails?
3. Bioclocks work by controlling chromosome coiling
4. Hot spots the key to controlling European carp in Australia
5. UT Southwestern researchers identify hundreds of genes controlling female fertility
6. Controlling for size may also prevent cancer
7. Protein protects embryonic stem cells versatility and self-renewal
8. Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows
9. Implanting embryonic cardiac cells prevents arrhythmias
10. Human embryonic stem cell -- derived bone tissue closes massive skull injury
11. Oosight microscope enables embryonic stem cell breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... so you might expect that most would have an ... dogs are distinctly more pessimistic than others, research from ... is exciting because it measures positive and negative emotional ... and dog owners an insight into the outlook of ... from the Faculty of Veterinary Science. Her PhD research ...
(Date:9/18/2014)... world-leading provider of scientific, technical and medical information ... Society (ARMS), recognized the academic research achievements of ... Researcher of the Year Awards. , The award ... Centre and in conjunction with the ARMS 2014 ... and New Zealand,s scientific community. Guest of honour ...
(Date:9/18/2014)... research has found clownfish larvae can swim up to 400 ... able to cope with environmental change. , Clownfish spend their ... but as babies they must wander the open ocean, says ... Excellence for Coral Reef Studies (Coral CoE) at James Cook ... go, but now we,ve been given a rare glimpse into ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Nemo's epic journey to find a new home 2
... CORAL GABLES, FL (February 4, 2014) ... builds on existing scholarship exploring the role of robotics ... their widespread deployment everywhere from the home, to hospitals, ... existing legal regimes or requires rethinking of various policy ...
... coral species, Psammogorgia hookeri , has been collected ... 25 meters in Peru,s Paracas National Reserve. The corals, ... their closest relative. Costa Rican researchers at the Smithsonian ... have named the coral for Yuri Hooker, biologist and ...
... Big data is changing the field of ecology. The shift ... new field: macrosystems ecology. "Ecologists can no longer sample ... said Patricia Soranno, Michigan State University professor of fisheries and ... lots of ecosystems and use lots of data to tackle ...
Cached Biology News:We Robot 2014 April 4th & 5th at University of Miami School of Law 2New scientific field looks at the big picture 2
(Date:9/19/2014)... The new , Healthcare and Life ... today on PharmaBoardroom.com for free download , ... the Spanish economy in 2009, and the austerity measures that ... pragmatic in times of trouble. "Despite the crisis, ... European market, and the general conditions to invest are favorable ...
(Date:9/18/2014)... 18, 2014 A novel robotic system ... scanner is currently being tested as part of a ... in Boston with the aim of determining if the ... prostate cancer biopsies faster, more accurate, less costly, and ... has the potential to deliver prostate cancer therapies with ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "Global and Chinese Stem Cell Industry Report, ... Stem cells are undifferentiated biological cells that can differentiate ... produce more stem cells. Stem cell therapy can be ... of hematological system disease), nervous system diseases, damage or ...
(Date:9/18/2014)... 18, 2014  U.S. biotech company Kultevat ... license for technology developed by the Donald Danforth ... plants, including for applications in production of natural rubber ... technology was developed under the direction of Roger ... former president of the Danforth Plant Science Center, and ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Kultevat obtains license of gene switch technology 2
... Fla., July 10 Cryo-Cell,International, Inc. (OTC Bulletin ... and most established family cord blood banks, today,announced ... ended May 31, 2008., Consolidated revenues for ... flat, as compared to approximately $4.5,million for the ...
... , - 1st Half-Year Sales Up 16%, - Revision Upwards of 2008 Sales Growth Guidance: (greater than or equal,to)12%, EUR millions ... 2008 08/07 ... ... 20.5 72 23.2 72 13 26.8 71 15 ...
... -- Yongye Biotechnology,International, Inc. ("Yongye" or the ... of plant and animal nutrients headquartered in,Beijing, ... Certified Public,Accountants and Advisors, P.C. as the ... engaged MSPC Certified Public Accountants and Advisors,P.C. ...
Cached Biology Technology:Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 2Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 3Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 4Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 5Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 6Stallergenes: Q2 2008 Sales up 18% Revision Upwards of 2008 Sales Growth 2Yongye Biotechnology International, Inc. Appoints New Independent Auditor 2
Mouse polyclonal antibody raised against a partial recombinant PREB. NCBI Entrez Gene ID = 10113...
... Thermomixer R offers maximum application versatility ... heating, and cooling. Its active heating/cooling ... and temperature control ranges. Five different ... micro test tubes, are available for: ...
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... contains sufficient materials for 1,464 array sample elements. , ... each , Blocker BSA in PBS (10X): 50 ... , BupH Phosphate Buffered Saline: 8 packs , ... West Pico Luminol Enhancer: 2 x 25 ml , ...
Biology Products: