Navigation Links
Controlling embryonic fate by association
Date:5/4/2008

Association determines fate in embryonic stem cells, said Baylor College of Medicine researchers in a report that appears in the current issue of the journal Nature Cell Biology.

These findings provide models of how the embryonic stem cell is maintained in its flexible state, said Dr. Zhou Songyang, professor of biochemistry and molecular biology at BCM and senior author of the report. It provides another hint as to how gene transcription is controlled in embryonic stem cells.

One aim of embryonic stem cell research is to understand how the cells determine whether they will keep dividing and maintain a pool of embryonic cells, or start the process of cellular differentiation that results in different cell types.

Songyang and his colleagues found that two critical embryonic cell proteins Nanog and Oct4 associate with specific components that are parts of transcription repression complexes. These complexes affect the way that genes are expressed and carry out their tasks in the cell.

A special complex called NODE (Nanog and Oct4-associated Deacetylase) contains a critical component called Mta1 along with histone deacetylases. NODE associates with Nanog and Oct4 to control the fate of embryonic stem cells, said Songyang.

Histones are critical parts of genomic DNA structures or chromatins, acting as spools around which the genetic material winds in the nucleus. The DNA wraps more tightly when deacetylase removes the acetyl tails from the histones. The tight wrapping makes it hard for genes to be transcribed into the message that allows them to carry out their roles in the cell.

Think of it as the parts of a car, said Songyang. If you think of Nanog as the engine that drives it, you realize that the car still needs accessories like wheels, the tailpipe, etc. We are interested in the big machinery of which proteins (like Nanog) are the drivers. We want to understand the enzymatic activities of the complexes. Then we need to identify the individual parts and ask the big question: How do different parts work together and why do you need special parts"

We noticed that there are many histone deacetylases, he said. Nanog uses these proteins to control gene expression and maybe also the chromatin state. When there is deacetylation, the gene is in a passive state.

The embryonic stem cell is always at the stage of deciding whether to divide (and make more embryonic stem cells) or to differentiate, Songyang said. All the extrinsic and intrinsic signals make the life of the embryonic stem cell transient. In other words, it has to be ready to go down either road.

It becomes an interesting question, said Songyang. Such a demanding state of readiness may mean that the embryonic stem cell requires a different complex at the chromatin than the somatic (or differentiated cell).


'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Controlling a sea of information
2. Controlling schistosomiasis: buffalo or snails?
3. Bioclocks work by controlling chromosome coiling
4. Hot spots the key to controlling European carp in Australia
5. UT Southwestern researchers identify hundreds of genes controlling female fertility
6. Controlling for size may also prevent cancer
7. Protein protects embryonic stem cells versatility and self-renewal
8. Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows
9. Implanting embryonic cardiac cells prevents arrhythmias
10. Human embryonic stem cell -- derived bone tissue closes massive skull injury
11. Oosight microscope enables embryonic stem cell breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... May 25, 2017 , ... Throughout this ... studies, describing how process development and economic goals were achieved in both industry ... a hollow-fiber bioreactor system, along with techniques for scaling production of mesenchymal stem ...
(Date:5/26/2017)... ... May 25, 2017 , ... LabRoots , the ... and scientists from around the world, is announcing a new textbook scholarship, the second ... undergraduate and graduate students, 17 years or older, pursuing a degree in one of ...
(Date:5/24/2017)... ... May 24, 2017 , ... Today, ... CLEARAS Water Recovery’s Advanced Biological Nutrient Recovery (ABNR™) technology at its 4,000,000 gallon ... million plant upgrade to sustainably meet current and future nutrient discharge regulations. The ...
(Date:5/24/2017)... BELLINGHAM, Washington, and WASHINGTON, DC, USA (PRWEB) , ... May 23, ... ... powerful driver of the economy as well as an enabler of life-saving medical and ... society for optics and photonics . They joined others in the scientific community today ...
Breaking Biology Technology: