Navigation Links
Control gene for developmental timing discovered
Date:9/28/2011

University of Alberta researchers have identified a key regulator that controls the speed of development in the fruit fly. When the researchers blocked the function of this regulator, animals sped up their rate of development and reached maturity much faster than normal.

The U of A research team, led by molecular geneticist Kirst King-Jones, noticed a peculiar behaviour of the protein they were studying, DHR4: The protein acted as a sentinel to either allow or prohibit the production of steroid hormones by moving periodically between the cell nucleus to the cytoplasm.

In insects, these steroid hormone pulses control the progression of the fruit fly's development through the various stages of their life cycle. When the researchers blocked the function of DHR4 in the steroid hormone-producing cells, the maturation stage was reached 20 per cent faster than normal. In human terms this would mean that sexual maturity would be reached years earlier than normal.

In humans, steroid hormones play fundamental roles in the development of bodies and the onset of disease. King-Jones says the U of A research defines a novel mechanism by which steroid hormone pulses are regulated.

Fruit flies are commonly used in genetic research labs to study fundamental biological processes important for human health. The genes in many human diseases have a recognizable match in the genome of the fruit fly. For instance, the insect is used as a genetic model for diseases and neurodegenerative disorders such as Alzheimer's and Parkinson's disease. The fly is also a research tool for the study of obesity, diabetes and cancer.

Prior to the breakthrough by U of A researchers, little was known about the mechanism by which the timing of steroid hormone pulses, and thereby the onset of maturation, are controlled.


'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. Gene controlling flowering boosts energy production from sorghum
2. Fast-evolving genes control developmental differences in social insects
3. Temperature controls the genetic message
4. Researchers discover a switch that controls stem cell pluripotency
5. Shaping up: Controlling a stem cells form can determine its fate
6. Polonium poisoning case sheds light on infection control practices
7. UMass Amherst entomologists begin to control winter moth infestation in eastern Massachusetts
8. Sensory experience and rest control survival of newborn neurons in adults
9. Possible biological control discovered for pathogen devastating amphibians
10. Rats control appetite for poison
11. Biocontrol of sweetpotato weevils
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
Breaking Biology Technology: