Navigation Links
Control gene for developmental timing discovered
Date:9/28/2011

University of Alberta researchers have identified a key regulator that controls the speed of development in the fruit fly. When the researchers blocked the function of this regulator, animals sped up their rate of development and reached maturity much faster than normal.

The U of A research team, led by molecular geneticist Kirst King-Jones, noticed a peculiar behaviour of the protein they were studying, DHR4: The protein acted as a sentinel to either allow or prohibit the production of steroid hormones by moving periodically between the cell nucleus to the cytoplasm.

In insects, these steroid hormone pulses control the progression of the fruit fly's development through the various stages of their life cycle. When the researchers blocked the function of DHR4 in the steroid hormone-producing cells, the maturation stage was reached 20 per cent faster than normal. In human terms this would mean that sexual maturity would be reached years earlier than normal.

In humans, steroid hormones play fundamental roles in the development of bodies and the onset of disease. King-Jones says the U of A research defines a novel mechanism by which steroid hormone pulses are regulated.

Fruit flies are commonly used in genetic research labs to study fundamental biological processes important for human health. The genes in many human diseases have a recognizable match in the genome of the fruit fly. For instance, the insect is used as a genetic model for diseases and neurodegenerative disorders such as Alzheimer's and Parkinson's disease. The fly is also a research tool for the study of obesity, diabetes and cancer.

Prior to the breakthrough by U of A researchers, little was known about the mechanism by which the timing of steroid hormone pulses, and thereby the onset of maturation, are controlled.


'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. Gene controlling flowering boosts energy production from sorghum
2. Fast-evolving genes control developmental differences in social insects
3. Temperature controls the genetic message
4. Researchers discover a switch that controls stem cell pluripotency
5. Shaping up: Controlling a stem cells form can determine its fate
6. Polonium poisoning case sheds light on infection control practices
7. UMass Amherst entomologists begin to control winter moth infestation in eastern Massachusetts
8. Sensory experience and rest control survival of newborn neurons in adults
9. Possible biological control discovered for pathogen devastating amphibians
10. Rats control appetite for poison
11. Biocontrol of sweetpotato weevils
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... January 22, 2016 ... addition of the  "Global Behavioral Biometric ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ... Behavioral Biometric Market 2016-2020"  report to ... and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ...
(Date:1/20/2016)... -- A market that just keeps on growing. Molecular ... in genomics knowledge. Learn all about it in this ... dynamic trends are pushing market growth and company valuations. ... - pathogen evolution - next generation sequencing - emergence ... of the role of genetic material in Disease and ...
(Date:1/18/2016)... Calif. , Jan. 18, 2016  Extenua ... software that simplifies the use and access of ... and go-to-market partnership with American Cyber.  ... brings extensive experience leading transformational C4ISR and Cyber ... and integrating the latest proven technology solutions," said ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... Curoverse announced ... On Azure, Arvados provides capabilities for managing and processing genomic and health data ... from major institutions collecting and analyzing genomic data,” said Adam Berrey chief executive ...
(Date:2/10/2016)... La Jolla CA (PRWEB) , ... February 10, 2016 , ... ... of new agents for the treatment of Alzheimer’s disease, announced today it has been ... to February 18th at the Breakers in Palm Beach, Florida. The purpose of ...
(Date:2/9/2016)... ... February 09, 2016 , ... With a presidential election ... Health Care Business Conference will bring together over 500 top healthcare leaders for a ... in transformation. The conference, organized by MBA students of the University of Pennsylvania’s Wharton ...
(Date:2/9/2016)... ... February 08, 2016 , ... Date ... S. Blumberg Institute at the Pennsylvania Biotechnology Center of Bucks County, 3805 Old ... Commonwealth Medical College (TCMC) will hold an open house for participants to learn ...
Breaking Biology Technology: