Navigation Links
Control by the matrix: RUB researchers decipher the role of proteins in the cell environment
Date:12/12/2011

How astrocytes, certain cells of the nervous system, are generated was largely unknown up to now. Bochum's researchers have now investigated what influence the cell environment, known as the extracellular matrix, has on this process. They found out that the matrix protein tenascin C has to be present in order for astrocytes to multiply and distribute in a controlled fashion in the spinal cord of mice. Together with colleagues from the RWTH Aachen, the scientists from RUB Department of Cell Morphology and Molecular Neurobiology report their findings in the journal Development.

Tenascin C regulates astrocyte development

Immature astrocytes produce tenascin C and secrete it into the extracellular matrix. From there, it controls the development of the cells. To characterise the role of the protein more precisely, the Bochum team lead by Prof. Dr. Andreas Faissner, Prof. Dr. Stefan Wiese and Dr. Michael Karus analysed astrocytes that were genetically manipulated so that they did not produce tenascin C. The scientists observed that the astrocytes without the protein divided for a longer period of time, and migrated later to their destination in the spinal cord. "As a consequence of the longer cell division phase, we found an increased number of mature astrocytes" explained Karus.

Gene activity altered

Also at the molecular level, the tenascin C manipulation leaves its mark. With colleagues at the RWTH Aachen, Bochum's researchers compared the gene activity in the spinal cord with and without tenascin C production. The absence of the protein not only affected genes that are typical of astrocytes. The scientists also documented expression level changes of genes that play a role for specific growth factors. These have an influence, for example, on the survival and division activity of different cell types.

Results also interesting for medical applications

Astrocytes take on a variety of tasks in the nervous system. They regulate the ion balance and the concentration of neurotransmitters, are part of the blood-brain barrier, and influence the activity of the nerve cells. In case of injuries to the central nervous system, or brain tumours, they form what are known as reactive astrocytes, which behave similarly to immature astrocytes. "So far, the function of tenascin C under such pathological conditions is largely unknown" said Karus. "However, if we find out more about the role of tenascin C during development, we will probably be able to better understand what affect it has, for example in spinal cord injuries."


'/>"/>

Contact: Dr. Michael Karus
Michael.Karus@ruhr-uni-bochum.de
49-234-322-4312
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Feasibility of using mycoherbicides to control illicit drug crops is uncertain
2. Controlled disorder -- scientists find way to form random molecular patterns
3. Biodegradable mulches successfully control weeds in container-grown arborvitae
4. Mid-ocean creatures control light to avoid becoming snacks
5. Scientists to use scent to control destructive rodent behavior
6. Impulsive versus controlled men: Disinhibited brains and disinhibited behavior
7. The future of airport passport control
8. New research from WALTHAM demonstrates the importance of portion control for maintaining healthy body weight in neutered female kittens
9. University of California Santa Barbara study reveals how gas, temperature controlled bacterial response to Deepwater Horizon spill
10. Scientists discover the proteins that control development of varicose veins
11. Control gene for developmental timing discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... (NYSE: DAL ) customers now can use fingerprints instead of ... Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May ... boarding process to allow eligible Delta SkyMiles Members who are enrolled in ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... ... threatened by various biotic and abiotic factors. During this educational webinar, participants will ... coffee, as well as gain a better understanding of how genomics is important ...
(Date:8/14/2017)... ... August 14, 2017 , ... Every year, ... researchers in the antibody community have recently come together to address this antibody ... the laboratory. , The team at Thermo Fisher Scientific ...
(Date:8/14/2017)... ... ... The Conference Forum has confirmed the one-day agenda for the ... 2017 at the Marriott Copley Place in Boston, MA. , Returning as program chair ... Pfizer Innovative Research Lab, Pfizer, who leads 19 industry speakers in discussing how and ...
(Date:8/11/2017)... (PRWEB) , ... August 11, 2017 , ... A staple ... campaign this month that will incorporate important key elements including a new digital marketing ... community that has supported them, Bill Miller has partnered with the South Texas Blood ...
Breaking Biology Technology: