Navigation Links
Contrast agent linked with brain abnormalities on MRI
Date:12/16/2013

gadolinium component remains in the body even in patients with normal renal function."

Dr. Kanda noted that because patients with multiple sclerosis tend to undergo numerous contrast-enhanced brain MRI scans, the hyperintensity of the DN seen in these patients may have more to do with the large cumulative gadolinium dose than the disease itself.

The mechanisms by which Gd-CM administration causes hyperintensity of the DN and GP remain unclear, Dr. Kanda said. Previous studies on animals and humans have shown that the ion can be retained in bone and tissue for several days or longer after administration.

"The hyperintensity of DN and GP on unenhanced T1WI may be due to gadolinium deposition in the brain independent of renal function, and the deposition may remain in the brain for a long time," Dr. Kanda suggested.

Dr. Kanda emphasized that there is currently no proof that gadolinium is responsible for hyperintensity on brain MRI. Further research based on autopsy specimens and animal experiments will be needed to clarify the relationship and determine if the patients with MRI hyperintensity in their brains have symptoms.

"Because patients who have multiple contrast material injections tend to have severe diseases, a slight symptom from the gadolinium ion may be obscured," Dr. Kanda said.

There are two types of Gd-CM , linear and macrocyclic, with distinct chemical compositions. Since the patients in the study received only the linear type, additional research is needed to see if the macrocyclic type can prevent MRI hyperintensity, according to Dr. Kanda.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research reveals contrasting consequences of a warmer Earth
2. Bees attracted to contrasting colors when looking for nectar
3. First oral agent to quell invasive macular degeneration, restore lost vision
4. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
5. Paints and coatings containing bactericidal agent nanoparticles combat marine fouling
6. Boston subway system to be used to test new sensors for biological agents
7. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
8. Novel non-antibiotic agents against MRSA and common strep infections
9. Production of FRP components without release agents
10. Developing second skin military fabric to repel chemical and biological agents
11. Preventive detention for oxidizing agents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Contrast agent linked with brain abnormalities on MRI
(Date:6/24/2015)... DUBLIN , June 22, 2015 ... has announced the addition of the "Huawei ... Analysis" report to their offering. ... going to the opposite direction than Apple,s and ... innovative fingerprint sensor developed by Fingerprint Cards, a ...
(Date:6/23/2015)... 23, 2015   Valencell, a leader ... of a recent study that illustrates its PerformTek ... during activity. In a study conducted at Valencell,s ... with the Apple Watch against a chest strap ... during activity. The study demonstrated that Valencell,s biometric ...
(Date:6/17/2015)... und GERMANTOWN, Maryland , June 17, ... ®   Produktlinie mit DNA-Tests verbessert den Analyseprozess ... QGEN ; Frankfurt Prime Standard: QIA) hat heute ... der Produktlinie Investigator ® ... eingeführt. Die neuen Kits zur Erstellung genetischer Fingerabdrücke bieten ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6
... genetic and geographic data of the H5N1 avian flu ... They found that multiple strains of the virus originated ... many of the migration routes through which the strains ... strains develop and migrate, health officials can better limit ...
... hold a key to defeating another implacable foe: HIV. ... a drastically weakened rabies virus to ferry HIV-related proteins ... disease. The early evidence shows that the vaccine ?which ... , Reporting April 1, 2007 in the Journal of ...
... squeaky voices, but now helium is also helping people ... at the University of Alberta in Edmonton, Canada have ... oxygen allowed patients with chronic obstructive pulmonary disease (COPD) ... 245 per cent. COPD is a disease of the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Jefferson scientists find rabies-based vaccine could be effective against HIV 2Helium helps patients breathe easier 2
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome and OpenBiome ... on mechanics of fecal microbiota transplantation in C. difficile patients. , SAN FRANCISCO, ... patients undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium difficile infections ...
(Date:6/30/2015)... DIEGO , June 30, 2015  The ... Education in Biosciences (CCE/Bio) and UC San Diego ... fermentation, to be held Aug.  12 – 14, ... ).  This three-day workshop provides an intense exposure ... industrial biotechnology, and is well-suited to biologists, process ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys today announced a ... archwire that allows orthodontists to simultaneously apply different forces to different teeth. The ... “We’re thrilled about taking SmartArch one step closer to commercial availability for orthodontists ...
(Date:6/29/2015)... ... June 29, 2015 , ... The global microfluidics market ... forecast period (2015 to 2020). The market is mainly driven by the rising ... for R&D. However, lack of adequate healthcare and research infrastructure in emerging markets, ...
Breaking Biology Technology:uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5
... Wis. - Tushaus Computer Services , which ... Millennium Design, Inc., a provider of Apple products and ... PCs and Macs, but also intellectual property and technology ... organizations. Financial terms of the deal were not disclosed. ...
... - The latest piece of the University of ... is in place. With the help of two corporate sponsors, ... fund-raising arm designed to promote technology transfer. , ,The foundation, ... has received $1 million in seed funding from both ...
... It's not too early to gauge the level of ... company formed by Beth Donley and University of ... already is rubbing elbows with interested investors, particularly angels, ... for eventually attracting big dollars from venture capitalists involves ...
Cached Biology Technology:UWM launches research foundation 2UW scientist, former WiCell director found stem cell company 2UW scientist, former WiCell director found stem cell company 3
... a valuable tool for removing SDS detergent ... SDS in biological samples imparts a negative ... inhibits enzymatic activity during digestion, and suppresses ... in mass spectrometry analyses. We recommend ...
Cells are grown in triple flasks, roller bottles, or NUNC Factory. Viability and growth curves are generated from a parallel representative culture....
... Life Sciences provides cost effective cell culture ... or monoclonal antibodies. Quality at a reasonable ... you require research or commercial product, we ... methods such as roller bottles, hollow fiber, ...
... cDNA normalization is essential for ... using high-throughput approaches, such as EST ... Most normalization methods are not well ... cDNA. The Evrogen TRIMMER kit, though, ...
Biology Products: