Navigation Links
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
Date:2/10/2014

KANSAS CITY, MOResearchers at the Stowers Institute for Medical Research have glimpsed two proteins working together inside living cells to facilitate communication between the cell's nucleus and its exterior compartment, the cytoplasm. The research provides new clues into how a crucial protein that is found in organisms from yeast to humans does its work.

The study, led by Stowers Investigator Sue Jaspersen, Ph.D., focused on a protein called Ndc1, which controls when and where a cell inserts holes into the double-walled membrane that surrounds its nucleus. In yeast, these holes become the sites for two essential structures: passageways called nuclear pore complexes, and spindle pole bodies, which anchor the cytoskeletal filaments that pull chromosomes to opposite sides of a dividing cell.

"Too many or too few insertion sites will have disastrous consequences," Jaspersen says, explaining that new nuclear pore complexes and spindle pole bodies must be created each time a cell prepares to divide to ensure genetic material can be properly distributed and daughter cells are equipped for gene activation and protein production. Her team's findings on Ndc1's interactions with a protein called Mps3, which appears to govern Ndc1's distribution on the nuclear envelope, are described in the February 10, 2014 issue of the Journal of Cell Biology.

Jaspersen and her colleagues set out to study Ndc1 because it is absolutely crucial for cell survival. They knew that in yeast, Ndc1 is embedded in the nuclear envelope and is needed for the insertion of both nuclear pore complexes and spindle pole bodies. But because cells are so sensitive to changes in Ndc1, scientists had been unable to learn much about how the protein functions.

Traditional genetic strategies of eliminating, altering, or increasing Ndc1 to test its function typically killed cells. "Having the exact right amount of Ndc1 is really critical," Jaspersen says. "Tha
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. American Chemical Society podcast: Detecting radioactive material in nuclear waste water
2. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
3. Improving detection of radioactive material in nuclear waste water
4. Volume of nuclear waste could be reduced by 90 percent, says new research
5. CNIO researchers identify a new gene that is essential for nuclear reprogramming
6. Invention could make spent nuclear fuel useful for irradiation purposes
7. UT MD Anderson scientists uncover the nuclear life of actin
8. Fallout from nuclear testing shows that the Achilles tendon cant heal itself
9. Biologists map rare case of fitness-reducing interaction in nuclear, mitochondrial DNA
10. How to make stem cells - nuclear reprogramming moves a step forward
11. University of Tennessee, ORNL lead national team to study nuclear fusion reactors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Conserved nuclear envelope protein uses a shuttle service to travel between job sites
(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions ... the entire spectrum of clinical research, is proud to ... the company,s comprehensive SaaS-based eClinical technology platform, has led ... the first two quarters of 2015.   Q2 2015 ... largest quarters measured by contract value sold in the ...
(Date:8/10/2015)... BOSTON and TELTOW, Germany ... SensoMotoric Instruments (SMI), a world leader in Eye ... the completion of its OEM Eye Tracking Platform for ... Eye Tracking Platform contains reference designs for seamless integration ... kiosk systems, virtual reality HMDs and augmented reality smart ...
(Date:8/5/2015)... , August 5, 2015 According ... Access Management Market by Software, Services, Vertical (BFSI, Airport, IT ... Geography - Global Forecast to 2020", published by MarketsandMarkets, ... Market globally into various segments. The global PIAM Market ... to $546.2 Million by 2019, at a CAGR of ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... acetyl CoA carboxylase 2,or ACC2, appears to turn the ... in part why the animals can eat more and ... Medicine,researchers.,The report that appears online today in the Proceedings ... cells in these mice bred to lack ACC2," said ...
... University,of California, San Diego have invented a process ... of specialized cells being sought as possible,treatments for ... and Shu Chien, UCSD bioengineering professors, and Christopher,J. ... in a paper published in the February issue ...
... have discovered a way to overcome one of the ... kill normal cells in the,process of eradicating cancer cells.,In ... of the Proceedings of the,National Academy of Sciences (PNAS), ... into a specially designed,virus. The virus eradicated prostate cancer ...
Cached Biology News:Lack of enzyme turns fat cells into fat burners 2Priming embryonic stem cells to fulfill their promise 2Priming embryonic stem cells to fulfill their promise 3Columbia research lifts major hurdle to gene therapy for cancer 2
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... announced the release of a groundbreaking new version of its flagship DNA design ... methodology breaks down complex DNA sequences into numerous genetic parts, which in turn ...
(Date:8/31/2015)... , Aug. 31, 2015 MabVax Therapeutics Holdings, ... announces that the Company,s lead antibody, HuMab 5B1, will ... separate presentations during the upcoming World Molecular Imaging Congress ... September 2-5, 2015. Researchers from the Department of Radiology ... results on the use of MabVax,s lead antibody as ...
(Date:8/31/2015)...  For people with Down syndrome, news from ... company, located in the Science + Technology Park at ... therapies yet for people with Down syndrome and other chromosome ... syndrome and Edwards syndrome aneuploidies in human cell cultures, ... Elixirgen plans to develop this technology into a treatment ...
(Date:8/31/2015)... SAN FRANCISCO, Calif. , Aug. 31, 2015 /PRNewswire/ ... the discovery and development of novel cancer immunotherapies, announced ... M.D., Ph.D., as Chief Executive Officer and William ... Wong and Ho join an experienced management team led ... Jordan Fridman , Ph.D., Chief Scientific Officer; ...
Breaking Biology Technology:GenoCAD Releases Combinatorial Design Tool to Optimize Protein Expression and Streamline DNA Synthesis Orders 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4New Down syndrome therapy discovered 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4
... , , , 7.6.4 Long PCR , ... as desired with every temperature , command, enables a , ... , With Long PCR, this function can be used ... elongation. , , ...
... , , , , , ... set of conditions that can be applied to all PCR amplifications. For ... used, the annealing temperatures , of the PCRs can differ ... stringent annealing temperature is a prerequisite for reliable results , ...
... , , , , ... fragment using the PCR* are an everyday occurrence in the lab. For example, , ... which hinder, , or even prevent, further analyses (cycle ... of the PCR result. In such cases, PCR , ...
Cached Biology Technology:PCR Optimization 2PCR Optimization 3Using Gradient PCR to determine the optimum annealing temperature. 2