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Conquest of land began in shark genome
Date:8/14/2007

adapt to swamps and terrestrial living, creating a distinct burst of development and more versatile appendages.

Using molecular markers to study the formation of skeletal cartilage in embryos of the spotted catshark, UF scientists isolated and tracked the activity of Hox genes, a group of genes that control how and where body parts develop in all animals, including people.

They discovered a phase of gene expression in sharks that was thought until recently to occur only when digits began to form in limbed animals.

Why, then, dont sharks have fingers?

Renata Freitas and GuangJun Zhang, co-authors of the paper and graduate students in the zoology department of the College of Liberal Arts and Sciences, speculate that sharks and many other types of fish do not form more dramatic appendages during this late phase of Hox gene expression because it occurs briefly and only in a narrow band of cells, compared with the more extended time frame and larger anatomical area needed to prefigure the hand and foot in limbed animals.

We know when this particular Hox gene is mutated in humans, it results in malformations of fingers and toes, Cohn said. Until now it was thought these mutations were affecting a relatively recent innovation in the genetic process of limb development. Our results show that this phase of Hox expression is much more ancient and suggest that if the origin of digits involved a prolonged activity of Hox genes, a truncated period could result in defective digits.

In a parallel study, researchers at the University of Chicago found this second phase of gene expression in paddlefish, a primitive living descendant of early fish with the first bony skeletons.

Finding the second phase in sharks, which have skeletons consisting not of bone but of cartilage, means the genetic processes necessary to muster fingers and toes existed more than 500 million years ago in the common ancestor of fish with cartila
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Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

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