Navigation Links
Concurrent imaging of metabolic and electric signals in the heart
Date:10/23/2009

Cardiac rhythm disorders can result from disturbances in cardiac metabolism. These metabolic changes are tightly linked with specific cardiac electrophysiology (CEP) abnormalities, such as depressed excitability, impaired intra- and extracellular conductivities, wave propagation block, and alteration of conduction velocity, action potential amplitude, and duration. The altered electrophysiology eventually can lead to arrhythmias, fibrillation, and cardiac death; therefore, understanding the spatiotemporal complexity of the relationship between metabolism and electrophysiology is the challenge in developing new approaches for treatment of cardiac diseases. The optical system for simultaneous imaging electrical and metabolic quantities in the heart was developed by scientists at Vanderbilt University. The advantages of their imaging system over others include an optional software camera calibration routine that eliminates the need for precise camera alignment. The system allows for rapid setup, dichroic image separation, dual-rate imaging, and high spatial resolution, and it is generally applicable to any two-camera measurement. The authors provide a detailed description of a camera calibration algorithm along with multiple examples. They demonstrate the capabilities of this type of imaging system for recording not only the transmembrane potential and intracellular calcium, but other signals more directly related to myocardial metabolism, such as [K+]e, NADH, and reactive oxygen species, leading to the possibility of correlative multimodal cardiac imaging. The authors findings appear in the November issue of Experimental Biology and Medicine.

"The challenge in understanding cardiac rhythm disorders is to discern the dynamic relationship between multiple cardiac variables," John Wikswo notes. "This dual camera system opens up a new window for correlating metabolic and electrophysiological events, usually studied independently."

Veniamin S
'/>"/>

Contact: Veniamin Y. Sidorov
v.sidorov@vanderbilt.edu
615-322-4419
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. NSF funds states first imaging system for UAB microscale research lab
2. New Automatic cell feeding station PROcellcare for life cell imaging
3. Scary ancient spiders revealed in 3-D models, thanks to new imaging technique
4. Jet-propelled imaging for an ultrafast light source
5. Kornberg Associates Architects Selected to Develop Design for New Stanford University Imaging Center
6. Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
7. First neuroimaging study examining motor execution in children with autism reveals new insights
8. Ultrasound imaging now possible with a smartphone
9. SNM Symposium on Multimodality Cardiovascular Molecular Imaging
10. Fattysaurus or thinnysaurus? How dinosaurs measure up with laser imaging
11. Studies on imaging and tracking transplanted cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015  A man-made form of insulin delivered by nasal ... in adults with mild cognitive impairment and Alzheimer,s disease ... at Wake Forest Baptist Medical Center. The ... cognitive impairment (MCI) or mild to moderate Alzheimer,s dementia ...
(Date:1/22/2015)... 2015 , Europe,s ... The European Patent Office to present a video retrospective of the ... be featured: Christofer Toumazou and Sophie Wilson   ... winners of the Award   Starting on 22 January ...
(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, the ... eliminate the pain of trying to remember their usernames and ... fused to their smartphones. To assist people who have struggled ... company that created 1U and focuses on redefining identity, announced ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 31U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... led by Nancy Rabalais, Ph.D., from the Louisiana Universities Marine ... Mexico dead zone to be smaller than forecasted, measuring 3,000 ... to water just above the sea floor, was severe where ... in most years. Earlier this summer, NOAA-sponsored forecast ...
... system in the developing nervous system is linked to smaller ... to movement, memory and emotion, according to new research led ... published in the August issue of the journal Nature ... as cerebellar interneurons are targeted for DNA damage and are ...
... 2009) Crack open the latest medical textbook to the ... hard pressed to find the term "immunology" anywhere. This is ... exceptions, distant cousins. However, a group of papers ... from Harvard Medical School researchers, have linked type 2 diabetes ...
Cached Biology News:Smaller than expected, but severe, dead zone in Gulf of Mexico 2Scientists track impact of DNA damage in the developing brain 2Scientists track impact of DNA damage in the developing brain 3Common allergy drug reduces obesity and diabetes in mice 2Common allergy drug reduces obesity and diabetes in mice 3Common allergy drug reduces obesity and diabetes in mice 4
(Date:1/23/2015)... 2015 Biofertilizers stimulate microbial activities in ... and phosphorous through the activities in the soil or ... due to the stress on reducing environmental pollution and ... report defines and segments the bio fertilizers market with ...
(Date:1/22/2015)... COLUMBIA, Md. (PRWEB) January 22, 2015 ... of its new UV-1280 multipurpose UV-visible spectrophotometer. Offering ... compact, high-quality instrument is ideal for applications in ... and life science. , The user-friendly UV-1280 enables ...
(Date:1/22/2015)... (PRWEB) January 21, 2015 Cambridge Semantics, the ... technology, today announced that 2014 was a record-breaking year across ... capabilities of the Anzo Smart Data Platform and our Smart ... utilize insights from diverse data which led to record growth ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... PLYMOUTH MEETING, Pa., Nov. 5 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: ... the Company plans to release third quarter 2009 financial results ... The Company will hold a conference call ... quarter 2009 results. Listeners may access the call by,dialing ...
... This webinar, ... continuous flow chemistry processing, will deal with the application of the ReactIR flow cell inline ... 670 publications has been recognized with several prestigious prizes and awards, including most recently the ... Columbia, ...
... , ROCKVILLE, Md., Nov. 4 ... next-generation antibody drug development, today announced that it has ... Enterprise Associates (NEA), one of the world,s leading venture ... novel, multi-specific antibody-like molecules that address two or more ...
Cached Biology Technology:BMP Sunstone to Report Third Quarter 2009 Financial Results 2Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 2Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 3Zyngenia, Inc. Raises $10 Million in Series A Funding 2Zyngenia, Inc. Raises $10 Million in Series A Funding 3Zyngenia, Inc. Raises $10 Million in Series A Funding 4
... Caspase-9 Pan-Caspase In Situ Assay Kit, Fluorescein ... active caspases in cells undergoing apoptosis. The ... for use in diagnostic or therapeutic procedures. ... use a novel approach to detect active ...
... silencing experiments often call for critical, ... Transfection Agent refines siRNA transfection protocols ... lipid-based formulation can be used to ... are subcultured without increased cytotoxicity. ...
... as well as other yeasts, has become ... laboratories. The ability to transform whole cells ... DNAs using lithium based buffers and polyethylene ... library screening easy and reliable, especially when ...
...
Biology Products: