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Concentrating on different aspects of pain leads to breakthrough in migraine genetics
Date:4/17/2008

relatives. All of these findings depended on the newly discovered aspect of migraine genetics: different types of pain such as pain that pulsates or pain that is unilateral are more closely linked to specific genetic loci than general pain, Palotie states.

In this study, researchers were able for the first time to convincingly demonstrate a genomic locus to be linked to migraine susceptibility in two diverse populations. This is especially interesting as Finland and Australia are genetically distant, and also as it tied together previous research, resulting in very robust evidence for pinpointing the susceptibility region.

This study is the first international collaboration as well as the largest linkage study in migraine to date. It successfully applied new analysis strategies in detecting the locus and thus paved the way for subsequent large association studies, Palotie and Anttila say. According them, this study gives new hope to deciphering the migraine pathways and therefore discovering targets for future treatments, as well as discovering the first migraine gene variants.


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Contact: Aarno Palotie
aarno.palotie@helsinki.fi
44-782-537-2753
University of Helsinki
Source:Eurekalert

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