Navigation Links
Concentrating on different aspects of pain leads to breakthrough in migraine genetics
Date:4/17/2008

Migraine is the most common cause of episodic headache, and by far the most common neurological cause of a doctors visit. It affects some 15% of the population, including some 41 million people in Europe, and places a considerable burden on healthcare in both the developed and the developing world.

During the last few years, great strides have been made in discovering common genes influencing the susceptibility to common diseases, such as diabetes, Crohns disease and schizophrenia. However, no genes have yet been convincingly associated with migraine susceptibility, probably due to the high degree of variability of the disease phenotype combined with the lack of viable laboratory tests.

To address this problem, we developed a new analysis technique concentrating on different symptoms of migraine, says Professor Aarno Palotie (University of Helsinki, Finland, and the Sanger Institute, Cambridge, UK). The new technique was used in the large international study including 1700 migraine patients and their close relatives from 210 Finnish and Australian migraine families. The Finnish families had been ascertained through neurology clinics, while the Australian families had been collected through a twin study. An initial genome-wide microsatellite study was followed up by an independent targeted replication study.

Researchers identified one gene locus on chromosome 10q23, which showed significant evidence of genetic linkage in both populations studied as well as in the replication study. The gene locus was especially strongly linked to female migraineurs. In a further analysis, two independent previous studies, one Finnish and one Australian, had detected the same locus, but in those studies the level of evidence had been just below significance, and thus the connection had so far been missed, tells researcher Verneri Anttila from Paloties group.

This locus is thus linked to migraine in a total of 4000 migraineurs or their close relatives. All of these findings depended on the newly discovered aspect of migraine genetics: different types of pain such as pain that pulsates or pain that is unilateral are more closely linked to specific genetic loci than general pain, Palotie states.

In this study, researchers were able for the first time to convincingly demonstrate a genomic locus to be linked to migraine susceptibility in two diverse populations. This is especially interesting as Finland and Australia are genetically distant, and also as it tied together previous research, resulting in very robust evidence for pinpointing the susceptibility region.

This study is the first international collaboration as well as the largest linkage study in migraine to date. It successfully applied new analysis strategies in detecting the locus and thus paved the way for subsequent large association studies, Palotie and Anttila say. According them, this study gives new hope to deciphering the migraine pathways and therefore discovering targets for future treatments, as well as discovering the first migraine gene variants.


'/>"/>

Contact: Aarno Palotie
aarno.palotie@helsinki.fi
44-782-537-2753
University of Helsinki
Source:Eurekalert

Related biology news :

1. Adaptation to parasites drive African fishes along different evolutionary paths
2. Plants can be used to study how and why people respond differently to drugs
3. 454 Sequencing uncovers a genetic basis for different social behaviors in wasp
4. Researchers discover important tool in understanding differentiation in human embryonic stem cells
5. At the root of nutrient limitation, ecosystems are not as different as they seem
6. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
7. Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
8. Severe asthma may be a different form of the disease
9. Scientist postulates 4 aspects of humaniqueness differentiating human and animal cognition
10. Computation to unravel how genes are regulated and shed light on how cells become different
11. Insects evolved radically different strategy to smell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
(Date:5/23/2017)...  Hunova, the first robotic gym for the rehabilitation and functional motor ... Genoa, Italy . The first 30 robots will be ... USA . The technology was developed and patented at the ... spin-off Movendo Technology thanks to a 10 million euro investment from entrepreneur ... ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced that ... SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 ... cross the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
Breaking Biology Technology: