Navigation Links
Concentrating on different aspects of pain leads to breakthrough in migraine genetics

Migraine is the most common cause of episodic headache, and by far the most common neurological cause of a doctors visit. It affects some 15% of the population, including some 41 million people in Europe, and places a considerable burden on healthcare in both the developed and the developing world.

During the last few years, great strides have been made in discovering common genes influencing the susceptibility to common diseases, such as diabetes, Crohns disease and schizophrenia. However, no genes have yet been convincingly associated with migraine susceptibility, probably due to the high degree of variability of the disease phenotype combined with the lack of viable laboratory tests.

To address this problem, we developed a new analysis technique concentrating on different symptoms of migraine, says Professor Aarno Palotie (University of Helsinki, Finland, and the Sanger Institute, Cambridge, UK). The new technique was used in the large international study including 1700 migraine patients and their close relatives from 210 Finnish and Australian migraine families. The Finnish families had been ascertained through neurology clinics, while the Australian families had been collected through a twin study. An initial genome-wide microsatellite study was followed up by an independent targeted replication study.

Researchers identified one gene locus on chromosome 10q23, which showed significant evidence of genetic linkage in both populations studied as well as in the replication study. The gene locus was especially strongly linked to female migraineurs. In a further analysis, two independent previous studies, one Finnish and one Australian, had detected the same locus, but in those studies the level of evidence had been just below significance, and thus the connection had so far been missed, tells researcher Verneri Anttila from Paloties group.

This locus is thus linked to migraine in a total of 4000 migraineurs or their close relatives. All of these findings depended on the newly discovered aspect of migraine genetics: different types of pain such as pain that pulsates or pain that is unilateral are more closely linked to specific genetic loci than general pain, Palotie states.

In this study, researchers were able for the first time to convincingly demonstrate a genomic locus to be linked to migraine susceptibility in two diverse populations. This is especially interesting as Finland and Australia are genetically distant, and also as it tied together previous research, resulting in very robust evidence for pinpointing the susceptibility region.

This study is the first international collaboration as well as the largest linkage study in migraine to date. It successfully applied new analysis strategies in detecting the locus and thus paved the way for subsequent large association studies, Palotie and Anttila say. According them, this study gives new hope to deciphering the migraine pathways and therefore discovering targets for future treatments, as well as discovering the first migraine gene variants.


Contact: Aarno Palotie
University of Helsinki

Related biology news :

1. Adaptation to parasites drive African fishes along different evolutionary paths
2. Plants can be used to study how and why people respond differently to drugs
3. 454 Sequencing uncovers a genetic basis for different social behaviors in wasp
4. Researchers discover important tool in understanding differentiation in human embryonic stem cells
5. At the root of nutrient limitation, ecosystems are not as different as they seem
6. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
7. Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
8. Severe asthma may be a different form of the disease
9. Scientist postulates 4 aspects of humaniqueness differentiating human and animal cognition
10. Computation to unravel how genes are regulated and shed light on how cells become different
11. Insects evolved radically different strategy to smell
Post Your Comments:
(Date:10/29/2015)... Oct. 29, 2015  Connected health pioneer, Joseph ... explosion of technology-enabled health and wellness, and the business ... The Internet of Healthy Things . ... smartphones even existed, Dr. Kvedar, vice president, Connected Health, ... care delivery, moving care from the hospital or doctor,s ...
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
(Date:10/26/2015)... , October 26, 2015 /PRNewswire/ ... --> adds Biometrics ... to 2021 as well as Emerging ... research reports to its collection of ... . --> ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... and HOLLISTON, Mass. , Nov. 25, ... HART ), a biotechnology company developing bioengineered organ ... Jim McGorry will present at the LD Micro ... at 2:30 p.m. PT. The presentation will be webcast ... days. Management will also be available at the conference ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be presenting at ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. PT ... provide a corporate overview. th Annual Oppenheimer Healthcare ... ET/10:00 a.m. PT . Jim Mazzola , vice president ... --> th Annual Oppenheimer Healthcare Conference in ...
(Date:11/24/2015)...  Clintrax Global, Inc., a worldwide provider of clinical research services ... that the company has set a new quarterly earnings record in ... growth posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , ...
Breaking Biology Technology: