Concentrating on different aspects of pain leads to breakthrough in migrain... ( Migraine is the most common cause of...)

Concentrating on different aspects of pain leads to breakthrough in migraine genetics

Date:4/17/2008

Migraine is the most common cause of episodic headache, and by far the most common neurological cause of a doctors visit. It affects some 15% of the population, including some 41 million people in Europe, and places a considerable burden on healthcare in both the developed and the developing world.

During the last few years, great strides have been made in discovering common genes influencing the susceptibility to common diseases, such as diabetes, Crohns disease and schizophrenia. However, no genes have yet been convincingly associated with migraine susceptibility, probably due to the high degree of variability of the disease phenotype combined with the lack of viable laboratory tests.

To address this problem, we developed a new analysis technique concentrating on different symptoms of migraine, says Professor Aarno Palotie (University of Helsinki, Finland, and the Sanger Institute, Cambridge, UK). The new technique was used in the large international study including 1700 migraine patients and their close relatives from 210 Finnish and Australian migraine families. The Finnish families had been ascertained through neurology clinics, while the Australian families had been collected through a twin study. An initial genome-wide microsatellite study was followed up by an independent targeted replication study.

Researchers identified one gene locus on chromosome 10q23, which showed significant evidence of genetic linkage in both populations studied as well as in the replication study. The gene locus was especially strongly linked to female migraineurs. In a further analysis, two independent previous studies, one Finnish and one Australian, had detected the same locus, but in those studies the level of evidence had been just below significance, and thus the connection had so far been missed, tells researcher Verneri Anttila from Paloties group.

This locus is thus linked to migraine in a total of 4000 migraineurs or their close
'/>"/>

Contact: Aarno Palotie
aarno.palotie@helsinki.fi
44-782-537-2753
University of Helsinki
Source:Eurekalert

0

GOOD

Page: 1 2
Related biology news :

1. Adaptation to parasites drive African fishes along different evolutionary paths
2. Plants can be used to study how and why people respond differently to drugs
3. 454 Sequencing uncovers a genetic basis for different social behaviors in wasp
4. Researchers discover important tool in understanding differentiation in human embryonic stem cells
5. At the root of nutrient limitation, ecosystems are not as different as they seem
6. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
7. Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
8. Severe asthma may be a different form of the disease
9. Scientist postulates 4 aspects of humaniqueness differentiating human and animal cognition
10. Computation to unravel how genes are regulated and shed light on how cells become different
11. Insects evolved radically different strategy to smell

Post Your Comments:

(Date:2/7/2010)... Cancer Institute (NCI) have found that the prevalence of ... women without a personal history of breast cancer is ... of developing breast cancer in women who are at ... survey are published in the February issue of ... the American Association for Cancer Research. , The ...

(Date:2/7/2010)... habitat types can help maintain more stable butterfly populations ... published today (8 February 2010) in the journal ... scientists from the Centre for Ecology & Hydrology, Butterfly ... how we might design landscapes better to help conserve ... data (from satellite images) to collect information on the ...

(Date:2/7/2010)... announced today (7 Feb) they have identified for the ... humans. The team analyzed more than 500,000 genetic variations ... which are located near a gene called TERC. ... today by researchers from the University of Leicester and ... the Netherlands, was funded by The Wellcome Trust and ...

Breaking Biology News(10 mins):Few women take tamoxifen to prevent breast cancer 2 Conservation from space: Landscape diversity helps to conserve insects 2 Scientists identify first genetic variant linked to biological aging in humans 2 Indoor Tanning Association Fights Back Against Media Hype over Tanning Beds 53159 1 Indoor Tanning Association Fights Back Against Media Hype over Tanning Beds 53159 2 American Academy of Dermatology Commends Reclassification of Tanning Beds as Carcinogenic 53154 1 American Academy of Dermatology Commends Reclassification of Tanning Beds as Carcinogenic 53154 2 American Academy of Dermatology Commends Reclassification of Tanning Beds as Carcinogenic 53154 3 HPV Infection May Be Linked to Poor Head and Neck Cancer Survival Rates in African Americans 53150 1 HPV Infection May Be Linked to Poor Head and Neck Cancer Survival Rates in African Americans 53150 2 HPV Infection May Be Linked to Poor Head and Neck Cancer Survival Rates in African Americans 53150 3 HPV Infection May Be Linked to Poor Head and Neck Cancer Survival Rates in African Americans 53150 4

[0] Few women take tamoxifen to prevent breast cancer [0] Conservation from space: Landscape diversity helps to conserve insects [0] Scientists identify first genetic variant linked to biological aging in humans

... turn back the biological clock and extend their lifespan ... report. , Their study, published online this month in ... the old notion of a tradeoff between reproduction and ... that "the more you reproduce, the shorter you,re going ...

... exercise seems to reduce anger expression in overweight but ... study on the topic looked at 208 typically sedentary ... afterschool aerobic exercise program or maintained their usual inactive ... common anger expressions such as slamming doors and hitting, ...

... is probably the largest contaminant of our body. That ... humans has not been proven convincingly. The current Editorial ... Technology reflects on this and concludes that this ... to take measures to reduce our exposure from ...

Other Biology News:Old flies can become young moms 2 Exercise helps overweight children reduce anger expression 2 Mineral oil contamination in humans: A health problem? 2

Old flies can become young moms Exercise helps overweight children reduce anger expression Mineral oil contamination in humans: A health problem?

(Date:2/8/2010)... Solutions (HDS) is pleased to announce that it has hired Lisa ... experts. Ms. Wichman joins HDS as an Account Manager and will focus ... AnalyticsPRO Division as the Manager of that group Omaha, NE. , ... ... (HDS) is pleased to announce the hiring of a new Account ...

(Date:2/5/2010)... has passed as fact among historians, journalists and politicians, ... the floor of the U.S. Congress: British forces used ... , But that claim has never been fully ... a historian at Colgate University. According to Douglas,s research, ... of Modern History , no such incident ever occurred. ...

(Date:2/5/2010)... Spanish . , Scientists at the ... for the first time different antioxidant compounds from foods ... herb called Teucrium polium. They have used two new ... have enabled them to identify and quantify a great ... , Functional foods such as olive oil, honey, walnuts ...

(Date:2/5/2010)... team of chemists from the University of Valencia (UV) ... an amphora found among remains at Lixus, in Morocco, ... fragments inside the 2,000-year-old vessel, which could be fragments ... group of archaeologists from the UV discovered a sealed ... founded by the Phoenicians near Larache, in Morocco. Since ...

Breaking Biology Technology:Healthcare Data Solutions Announces Expansion of its Healthcare Customer Solutions Team With Two Key Additions 2 Healthcare Data Solutions Announces Expansion of its Healthcare Customer Solutions Team With Two Key Additions 3 Despite claims, UK did not gas Iraqis in the 1920s, new research finds 2 Despite claims, UK did not gas Iraqis in the 1920s, new research finds 3 Despite claims, UK did not gas Iraqis in the 1920s, new research finds 4 New antioxidant compounds have been identified in foods such as olive oil, honey and nuts 2 Chemical analyses uncover secrets of an ancient amphora 2

[0] Healthcare Data Solutions Announces Expansion of its Healthcare Customer Solutions Team With Two Key Additions [0] Despite claims, UK did not gas Iraqis in the 1920s, new research finds [0] New antioxidant compounds have been identified in foods such as olive oil, honey and nuts [0] Chemical analyses uncover secrets of an ancient amphora

... March 25 David Koos, Chairman and CEO of ... BMSN), told the editors of The Wall Street Transcript, ... is an excellent possibility that the company "would have ... alliances and contracts "with companies engaged either in cryogenic ...

... Shire plc (LSE: SHP, NASDAQ:, SHPGY ), ... and Accounts in respect of the year ended December ... previously announced unaudited full,year 2008 results, prepared in accordance ... earnings announcement on February 19,2009. , ...

... 25 InNexus Biotechnology Inc., (OTC Bulletin Board: IXSBF; ... company commercializing the next generation of monoclonal antibodies based ... to announce that the Company has entered into a ... aggregate amount of up to USD$2.5 million. The loan ...

Bio-Matrix Scientific Group CEO Tells Wall Street Transcript That 'Positive Cash Flow' Is Possible in '09; New Stem Cell Banking Facility Is Growth Vehicle Over the Next Two Years, Says CEO in Exclusive News Interview Publication of Shire plc's Annual Report 2008 InNexus Biotechnology Announces a Loan Facility of up to USD$2.5 Million

... Block is an anodized aluminum, solvent-resistant block ... to provide efficient thermal transfer to samples ... of the HT96 Isothermal Block replaces Cat. ... design allowing for compatibility with robotic applications. ...

...

Biology Products:

HT96 Isothermal Block from Novagen LABQUAKE from Barnstead Thermolyne Suramin, Sodium Salt from Calbiochem Microtiter Wells from Bethyl Laboratories

Concentrating on different aspects of pain leads to breakthrough in migrain...( Migraine is the most common cause of...)