Navigation Links
Conaway Lab identifies novel mechanism for regulation of gene expression
Date:9/26/2008

The Stowers Institute's Conaway Lab has demonstrated that an enzyme called Uch37 is kept in check when it is part of a human chromatin remodeling complex, INO80. The results were published in today's issue of Molecular Cell.

Uch37 is a "deubiquitinating enzyme" that can remove protein tags (called ubiquitin) from other proteins. The presence of one kind of ubiquitin tag on a protein can mark it for destruction, but others serve as marks to affect the activity of a protein. INO80 is a chromatin remodeling complex that is believed to function in both gene regulation and DNA repair by "unpacking" DNA from nucleosomes to allow access to chromosomal DNA.

Previously, the Conaway Lab demonstrated that Uch37 is associated with another multiprotein complex, the proteasome a large protein complex that degrades unneeded or damaged proteins. In the new paper, the team shows that when bound to INO80, Uch37 can also be activated in the presence of proteasomes. Although the mechanism involved isn't totally clear, it seems to occur via a "touch and go" mechanism, in which proteasomes interact transiently with Uch37.

"Our findings suggest that activation of INO80-associated Uch37 by transient association of proteasomes with the INO80 complex could be one way proteasomes help to regulate gene expression," said Tingting Yao, Ph.D., Postdoctoral Research Fellow and lead author on the paper.

"Tingting's discovery of communication between INO80 and the proteasome provides new clues into the functions of both of these regulatory complexes," said Joan Conaway, Ph.D., Investigator and senior author on the paper. "In addition, it provides new insights into how deubiquitinating enzymes can be regulated the ability to regulate these enzymes is very important because promiscuous removal of ubiquitin marks could lead to a failure to regulate properly the activities or levels of key enzymes and proteins in cells."


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Baumann lab identifies elusive telomere RNA subunit in single cell model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... 26, 2017 , ... WonderWorks, Myrtle Beach’s science focused amusement ... of deep space exploration and inspire space enthusiasts. The exhibit features interactive exhibits ... guest appearance by former Shuttle Astronaut Don Thomas. , The intergalactic weekend kicks ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... its new Bioflash MailGuardtm mail security screening solution at the National Postal Forum ... MailGuard system provides a fast, highly accurate, easy to use and low cost ...
(Date:4/26/2017)... , April 26, 2017  Genisphere LLC, provider ... has signed a collaborative and sponsored research agreement ... Silvia Muro . The overall goal of the ... of various 3DNA designs and formulations after ... diseases of the vasculature as well as inflammatory ...
(Date:4/25/2017)... Diego, CA (PRWEB) , ... April 25, 2017 ... ... division of L3 Healthcare, is pleased to announce the company is now a ... management. The iMedNet software certification enables the company’s clinical research team to ...
Breaking Biology Technology: