Navigation Links
Conaway Lab identifies novel mechanism for regulation of gene expression
Date:9/26/2008

The Stowers Institute's Conaway Lab has demonstrated that an enzyme called Uch37 is kept in check when it is part of a human chromatin remodeling complex, INO80. The results were published in today's issue of Molecular Cell.

Uch37 is a "deubiquitinating enzyme" that can remove protein tags (called ubiquitin) from other proteins. The presence of one kind of ubiquitin tag on a protein can mark it for destruction, but others serve as marks to affect the activity of a protein. INO80 is a chromatin remodeling complex that is believed to function in both gene regulation and DNA repair by "unpacking" DNA from nucleosomes to allow access to chromosomal DNA.

Previously, the Conaway Lab demonstrated that Uch37 is associated with another multiprotein complex, the proteasome a large protein complex that degrades unneeded or damaged proteins. In the new paper, the team shows that when bound to INO80, Uch37 can also be activated in the presence of proteasomes. Although the mechanism involved isn't totally clear, it seems to occur via a "touch and go" mechanism, in which proteasomes interact transiently with Uch37.

"Our findings suggest that activation of INO80-associated Uch37 by transient association of proteasomes with the INO80 complex could be one way proteasomes help to regulate gene expression," said Tingting Yao, Ph.D., Postdoctoral Research Fellow and lead author on the paper.

"Tingting's discovery of communication between INO80 and the proteasome provides new clues into the functions of both of these regulatory complexes," said Joan Conaway, Ph.D., Investigator and senior author on the paper. "In addition, it provides new insights into how deubiquitinating enzymes can be regulated the ability to regulate these enzymes is very important because promiscuous removal of ubiquitin marks could lead to a failure to regulate properly the activities or levels of key enzymes and proteins in cells."


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Baumann lab identifies elusive telomere RNA subunit in single cell model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... aquatic environment on Earth, but when the climate changes ... the limit. The amount of time needed to adjust ... species cope in the future, reveals a new study ... the scientific journal Proceedings of the Royal Society ... increasing levels of greenhouse gases in the atmosphere. The ...
(Date:9/30/2014)... If you want your doctor to know what goes wrong ... a good idea to know what "normal" actually is. That,s ... issue of the FASEB Journal comes ... complete transcriptomea key set of molecules that can help scientists ... particular time. What,s more, they found never-before-detected gene activity and ...
(Date:9/30/2014)... People who suffer from asthma may think there,s not ... besides properly taking medications and avoiding allergic triggers. ... Annals of Allergy, Asthma and Immunology , the scientific ... Immunology (ACAAI), asthma sufferers can learn lessons about managing ... in the Annals article improved her asthma once she ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Scientists identify which genes are active in muscles of men and women 2Asthma symptoms kicking up? Check your exposure to air pollution 2
... used by bodybuilders could be the key to treating ... new research shows. The amino acid L-tyrosine had ... in laboratory tests on mice, significantly improving symptoms of ... New South Wales (UNSW) found. Trials showed that ...
... The EpiGen Consortium, an international alliance of the ... Sciences of the Agency for Science, Technology and ... Southampton, Medical Research Council Lifecourse Epidemiology Unit, ... announce the creation of a research collaboration with ...
... 22, 2011 /PRNewswire-iReach/ -- Researchers have demonstrated ... Curran eat significantly more fruits and vegetables and get ... 12 months ago.  By participating in the WellSteps ... in nutrition, physical activity, and sleep quality. Employees also ...
Cached Biology News:Hope for muscle wasting disease 2EpiGen announces collaboration with Nestlé 2New Study Shows Impact of Employee Wellness Efforts 2
(Date:10/2/2014)... BRIDGEWATER, N.J. , Oct. 2, 2014 /PRNewswire/ ... in synthetic biology, and Amneal Pharmaceuticals LLC ... volume in the U.S., today announced the formation ... a target active pharmaceutical ingredient (API).  Utilizing Intrexon,s ... collaboration is to develop a consistent, scalable, and ...
(Date:10/1/2014)...  Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" or the ... of high pressure-based sample preparation systems to the life ... to present at the 2 nd  Global Life ... The Conference will take place at the Warsaw Stock ... Schumacher , President and CEO of PBI, will present ...
(Date:10/1/2014)... The participants committed to not only creating unique ... time adjusting, tweaking and testing virtual models and 3D ... judging. , “I enjoyed being involved as a judge,” ... entries showed a commendable range exploring the technical capabilities ... medium and the creativity of the contestants.” , Array ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Slone ... Clinical Therapeutics, Healthcare IT, and Laboratory Testing industries, reported ... positions at the director level and above from July ... to stay on top of rapid breakthroughs in diagnostics, ... many diagnostic companies have been forced to fold, consolidate, ...
Breaking Biology Technology:Intrexon and Amneal Expand Relationship with Second Product Collaboration 2Intrexon and Amneal Expand Relationship with Second Product Collaboration 3Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 2Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 3Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 4Array Architects Challenges Staff to Create with 3D Printer 2Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2
... Karudapuram, Ph.D. and David Batey Ph.D. , ... , ... real-time quantitative PCR (qPCR) protocol was used on the MJ Research ... Two hydrolysis probes, one labeled with VIC and the other labeled with FAM, ...
... Ph.D.1, Richard Kurtz, Ph.D.2, David Batey, Ph.D.2 , ... Sciences, Stanford University, Stanford, CA , , ... , ... the amoA gene were used to measure the ammonia-oxidizing bacteria (AOB) population in soils maintained ...
... , AquaPure Genomic DNA Isolation Kit , ... DNA (15-ml tube prep), , Method ... 1. Add 1 ml body fluid (e.g., cerebrospinal fluid, plasma, saliva, serum, , ... , tube containing 5 ml cell lysis solution. Pipet up and ...
Cached Biology Technology:Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System 2Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System 3Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System 4Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System 5Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System 6Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System 7Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 2Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 3Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 4Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 5Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 6Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 7Genomic DNA Isolation From 1 ml of Body Fluid 2
... FailSafe™ PCR System is the only PCR ... time and every time. It provides accuracy, ... the source or the property of the ... PCR Enzyme Mix, a unique blend of ...
With L-glutamine and potassium bicarbonate. Sterile, Insect cell culture tested...
Mol wt: average mol wt12,360.96 Da by calculation...
Originally developed for the culture of Drosophila; suitable for culture of other dipteran cell lines. Powder, Insect cell culture tested...
Biology Products: