Navigation Links
Computer simulations point to key molecular basis of cystic fibrosis
Date:2/29/2008

gether for NBD1 to fold correctly. These interactions are modulators of CFTR folding, and hence, they are potential modulators of CF.

Computer simulations approximate our understanding of natural phenomena. That our simulations correlated with known experimental studies is remarkable, Dokholyan said. More importantly, the molecular details of aberrant NBD1 folding provides guidance for the design of small molecule drugs to correct the most prevalent and pathogenic mutation in CFTR.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Primate behavior explained by computer agents
2. Computer program traces ancestry using anonymous DNA samples
3. A computer for your mouse!
4. New approach builds better proteins inside a computer
5. Computer solution to delivery problem
6. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
7. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
8. Computer savvy canines
9. Brain-computer link systems on the brink of breakthrough, study finds
10. Computer learns dogspeak
11. Computer-based tool aids research, helps thwart questionable publication practices

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2009)... By producing some of the highest resolution image...tists have a deeper understanding how biomolecules... lead to a new treatment for kidney stones using b...e Nov. 23 online edition of the journal Proceedin...how peptides interact with mineral surfaces by acc...
(Date:11/23/2009)...thern California biomedical engineer and cardiolog... to help clinicians distinguish cardiac emergencie...s manageable with drugs and lifestyle change. , ... the arteries feeding the heart, offer an inside v...od vessels, often revealing deposits of a dangerou...
(Date:11/23/2009)... classify the gender of six-week-old turkey poults...led shortly after birth, according to Dr. Gerald S...n Germany and his team. Their use of infrared spec...ows that it is a fast and accurate method with the...identify and select female eggs for breeding. The ...
Breaking Biology News(10 mins):Scientists watch as peptides control crystal growth with 'switches, throttles and brakes' 2Scientists watch as peptides control crystal growth with 'switches, throttles and brakes' 3Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which 2Rescuing male turkey chicks 2Lumension Podcast Highlights Evolving State of Endpoint Security and Why Organizations Need to Augment Blacklisting with Whitelisting to Optimize Secu 57459 1Lumension Podcast Highlights Evolving State of Endpoint Security and Why Organizations Need to Augment Blacklisting with Whitelisting to Optimize Secu 57459 2Lumension Podcast Highlights Evolving State of Endpoint Security and Why Organizations Need to Augment Blacklisting with Whitelisting to Optimize Secu 57459 3Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 1Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 2Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 3Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 4Relieving pain affecting millions 57450 1Relieving pain affecting millions 57450 2Relieving pain affecting millions 57450 3
...ers have discovered a pivotal new player in early ... full-blown fat, according to a report in the Febr...ed by Cell Press. Drugs that block some activities...XOR), might therefore offer a novel antiobesity th...the researchers said. , Known for its role in prod...
...upon a massive database established with funds fro... Diseases (NIAID), one of the National Institutes ...t comprehensive analysis to date of published infl...virus that are recognized by the immune system. Th...a Institute for Allergy and Immunology (LIAI), are...
...n known as the "master watchman of the genome" for...amage has been found to provide an entirely differ...kin to tan in response to ultraviolet light from t... cancer, the fastest-increasing form of cancer in ...e journal Cell, researchers at Dana-Farber Cancer ...
Other Biology News:New player in commitment to life as a fat cell 2New details on how the immune system recognizes influenza 2New details on how the immune system recognizes influenza 3New details on how the immune system recognizes influenza 4'Guardian of the genome' protein found to underlie skin tanning 2'Guardian of the genome' protein found to underlie skin tanning 3
(Date:11/24/2009)..., TORONTO,Nov.24/PRNewswire-FirstCall/-Hamilton...leadingproviderofadvancedlasersystemsandinstrument...odayreportedoperationalandfinancialresultsfortheth...hts,-Revenuewas$1.46millioncomparedwith$1.43milli...dwith66.1percentinQ3,2008,-Netlossreducedto$148,00...
(Date:11/24/2009)...009/PRNewswire-FirstCall/--ArenaPharmaceuticals,In...cheduledtopresentatthePiperJaffray21stAnnualHealth...me(8:30a.m.PacificTime)attheNewYorkPalaceHotelinNe...tiveOfficer,isscheduledtoprovideanoverviewofthecom...ograms. ,, Aliveaudiowebcastofthepresentationwi...
(Date:11/24/2009)...ber24/PRNewswire/--HealthRoboticstodayannounced,th...elected,investors.ThisrecentlyformedToronto-basedc...,Inc.andwillmarket,install,andsupport,HealthRoboti...olutionaryproductofferingsi.v.STATION(TM),i.v.SOFT...rovideassistanceonan"asneeded,basis"toitsstrategic...
(Date:11/24/2009)... Chemical Abstracts Service (CAS), the global expe...atent office is now the world,s leading producer o...a trailed Japan,s patent office, the World Intelle... States Patent and Trademark Office (USPTO) for mo...PO in 2006, and exceeded Japan for the first time ...
Breaking Biology Technology:Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 2Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3
... Roche intends to acquire all outstanding shares o... Research and early development to operate as an i...ome headquarters of combined U.S. commercial opera... , , -- Innovation will be enhanced through a div...echnologies, partnerships and other key assets , ...
... The Mitsui trading company ...nounced a new partnership, which will create a joi...ologies Japan between Mitsui and Asahi. , ...009 -- The Mitsui trading company and the world re...rtnership, which will create a joint venture compa...
...w Molecular Tests and Increasing Case Volumes Driv...of 2008 as Compared to the Prior Year Period , , ...asdaq: CLRT ), a premier anatomic pathology and ...ts, oncologists, and the pharmaceutical industry, ...ts fourth quarter and year ended December 31, 2008...
Other Biology Technology:Roche and Genentech Reach a Friendly Agreement to Combine the Two Organizations and Create a Leader in Healthcare Innovation 2Roche and Genentech Reach a Friendly Agreement to Combine the Two Organizations and Create a Leader in Healthcare Innovation 3Roche and Genentech Reach a Friendly Agreement to Combine the Two Organizations and Create a Leader in Healthcare Innovation 4Roche and Genentech Reach a Friendly Agreement to Combine the Two Organizations and Create a Leader in Healthcare Innovation 5Roche and Genentech Reach a Friendly Agreement to Combine the Two Organizations and Create a Leader in Healthcare Innovation 6Roche and Genentech Reach a Friendly Agreement to Combine the Two Organizations and Create a Leader in Healthcare Innovation 7Alltech, Mitsui and Asahi Breweries Create New Venture 2Alltech, Mitsui and Asahi Breweries Create New Venture 3Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 2Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 3Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 4Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 5Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 6Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 7Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 8Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 9Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 10Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008 11
...ion of reagents and increased throughput, particul... is an automated dispenser designed for high-throu...4- and 96-well plates.This new-generation dispense...itch from 96- to 384- well plates and dispense up ...
MBS Satellite Thermal Cycler 384 Well from Thermo Scientific
Robotic MBS Thermal Cycler 384 Well from Thermo Scientific
Cable (20 mtrs) from Thermo Scientific
Biology Products: