Navigation Links
Computer simulation of protein malfunction related to Alzheimer's disease
Date:2/17/2010

Researchers at Universitat Autnoma de Barcelona (UAB) and University of Stockholm have created a computer modelling of the structural malfunctioning of the ApoE4 protein when it enters into contact with the Amyloid beta molecule, the main cause of Alzheimer's disease. The research, published in PLoS Computational Biology, supports experimental evidence that links ApoE4 with this pathology and opens up new exploration possibilities in understanding and fighting against the disease.

The research proposes a three-dimensional model which simulates the interaction between the peptide Amyloid beta and the different forms of Apolipoprotein E (ApoE) and offers a first molecular base for the comprehension of this phenomenon. Three possible ApoE forms exist in humans: ApoE2, ApoE3 and ApoE4. ApoE3 is the most common form, while ApoE4 is very closely linked to Alzheimer's disease.

The project was carried out by five researchers, including Jean-Didier Marchal and lex Perlvarez, lecturers at the UAB Departments of Chemistry and of Biochemistry and Molecular Biology (Centre for Biophysics Studies). Given the difficulty in carrying out in vitro experiments with the peptide Amyloid beta, researchers decided to create a computer simulation to establish the first approximation of the molecular mechanisms which relate it to ApoE4.

The developed model structurally reaffirms the experimental observations which link ApoE4 to this pathology. Researchers have observed that this protein tends to lose its functional structure in presence of the peptide Amyloid beta; this however does not occur with the ApoE2 and ApoE3 forms. According to researchers, these differences are due to subtle divergences between the structures of each form and would explain the different responses of carriers of forms 3 and 4 in the presence of Amyloid beta molecules.

The loss of the structure reveals the possibility of new explorations aimed at better understanding and fighting against Alzheimer's disease. The following stage of the study will consist in experimentally characterising this interaction, which is an essential aspect in the design of future therapies. Researchers also highlight that this project has made even more obvious the need for computer tools in all fields of research and of the new possibilities they represent in improving the study of complex molecular systems.


'/>"/>

Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-045-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

Related biology news :

1. Primate behavior explained by computer agents
2. Computer program traces ancestry using anonymous DNA samples
3. A computer for your mouse!
4. New approach builds better proteins inside a computer
5. Computer solution to delivery problem
6. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
7. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
8. Computer savvy canines
9. Brain-computer link systems on the brink of breakthrough, study finds
10. Computer learns dogspeak
11. Computer-based tool aids research, helps thwart questionable publication practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the medical ... premium product recently added to the range of products distributed by Ampronix. ... ... ... Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... Research and Markets has announced the addition of the ... The global biomarkers market has ... The market is expected to grow at a five-year compound annual ... $50.6 billion in 2015 to $96.6 billion in 2020. ... to 2020) are discussed. As well, new products approved in 2013 ...
(Date:6/22/2016)... LOS ANGELES , June 22, 2016   ... an SNNLive Video Interview with Dr. Nader Pourhassan ... a biotechnology company focused on the clinical development and ... and prevention of HIV infection, according to the company,s ... was recorded on Tuesday, June 7 th , 2016, ...
(Date:6/22/2016)... DIEGO , June 22, 2016   ViaCyte, ... first pluripotent stem cell-derived islet replacement therapy for the ... presentations at ISSCR 2016 Annual Meeting.  ISSCR 2016, the ... to 25th at Moscone West in San Francisco.  ... of the presentations are as follows:Event: , Focus Session: ...
(Date:6/22/2016)... (PRWEB) , ... June 22, 2016 , ... ... at placing a spotlight on immigrant achievements and contributions to North Texas and ... most important contributors from the immigrant community to the civic and economic vitality ...
Breaking Biology Technology: