Navigation Links
Computer simulation of protein malfunction related to Alzheimer's disease

Researchers at Universitat Autnoma de Barcelona (UAB) and University of Stockholm have created a computer modelling of the structural malfunctioning of the ApoE4 protein when it enters into contact with the Amyloid beta molecule, the main cause of Alzheimer's disease. The research, published in PLoS Computational Biology, supports experimental evidence that links ApoE4 with this pathology and opens up new exploration possibilities in understanding and fighting against the disease.

The research proposes a three-dimensional model which simulates the interaction between the peptide Amyloid beta and the different forms of Apolipoprotein E (ApoE) and offers a first molecular base for the comprehension of this phenomenon. Three possible ApoE forms exist in humans: ApoE2, ApoE3 and ApoE4. ApoE3 is the most common form, while ApoE4 is very closely linked to Alzheimer's disease.

The project was carried out by five researchers, including Jean-Didier Marchal and lex Perlvarez, lecturers at the UAB Departments of Chemistry and of Biochemistry and Molecular Biology (Centre for Biophysics Studies). Given the difficulty in carrying out in vitro experiments with the peptide Amyloid beta, researchers decided to create a computer simulation to establish the first approximation of the molecular mechanisms which relate it to ApoE4.

The developed model structurally reaffirms the experimental observations which link ApoE4 to this pathology. Researchers have observed that this protein tends to lose its functional structure in presence of the peptide Amyloid beta; this however does not occur with the ApoE2 and ApoE3 forms. According to researchers, these differences are due to subtle divergences between the structures of each form and would explain the different responses of carriers of forms 3 and 4 in the presence of Amyloid beta molecules.

The loss of the structure reveals the possibility of new explorations aimed at better understanding and fighting against Alzheimer's disease. The following stage of the study will consist in experimentally characterising this interaction, which is an essential aspect in the design of future therapies. Researchers also highlight that this project has made even more obvious the need for computer tools in all fields of research and of the new possibilities they represent in improving the study of complex molecular systems.


Contact: Maria Jesus Delgado
Universitat Autonoma de Barcelona

Related biology news :

1. Primate behavior explained by computer agents
2. Computer program traces ancestry using anonymous DNA samples
3. A computer for your mouse!
4. New approach builds better proteins inside a computer
5. Computer solution to delivery problem
6. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
7. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
8. Computer savvy canines
9. Brain-computer link systems on the brink of breakthrough, study finds
10. Computer learns dogspeak
11. Computer-based tool aids research, helps thwart questionable publication practices
Post Your Comments:
(Date:11/20/2015)... OXFORD, Connecticut , November 20, 2015 ... biometric authentication company focused on the growing mobile commerce ... its CEO, Gino Pereira , was recently interviewed ... The interview will air on this weekend on ... Bloomberg Latin America . --> NXTD ) ...
(Date:11/17/2015)... 17, 2015 Paris from ... --> Paris from 17 th until ... biometrics innovation leader, has invented the first combined scanner in ... same scanning surface. Until now two different scanners were required: ... can capture both on the same surface. This innovation ...
(Date:11/12/2015)...  A golden retriever that stayed healthy despite having ... provided a new lead for treating this muscle-wasting disorder, ... of MIT and Harvard and the University of São ... Cell, pinpoints a protective gene that boosts ... The Boston Children,s lab of Lou Kunkel , ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , November 26, 2015 ... Biobanking Market 2016 - 2020 report analyzes that ... integrity and quality in long-term samples, minimizing manual ... cost-effectiveness. Automation minimizes manual errors such as mislabeling ... efficiency. Further, it plays a vital role in ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. ... Gorman , President and CEO of Neurocrine Biosciences, will ... Conference in New York . ... visit the website approximately 5 minutes prior to the ... replay of the presentation will be available on the ...
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica ... on AngelList early in their initial angel funding process. Now, they are paying ... looking to make early stage investments in the microbiome space. In this, ...
(Date:11/24/2015)... /CNW/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the quarter ended September 30, 2015. Amounts, unless ... presented under International Financial Reporting Standards ("IFRS"). ... Andrew Rae , President & CEO of ... only value enriching for this clinical program, but ...
Breaking Biology Technology: