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Computer models help decode cells that sense light without seeing
Date:2/7/2014

elanopsin may open up new pathways in studying the evolution of light receptors in vertebrate and, in turn, the molecular basis of diseases, such as "seasonal affecting disorders," Olivucci said. "Moreover, it provides a model for developing sub-nanoscale sensors approaching the sensitivity of a single-photon."

For this reason, the LCPP group working together with Francesca Fanelli, Ph.D., of Italy's Universit di Modena e Reggio Emilia has used the methodology developed by Warshel and his colleagues to construct computer models of human melanopsin, bovine rhodopsin and squid rhodopsin. The models were constructed by BGSU research assistant Samer Gozem, Ph.D., BGSU visiting graduate student Silvia Rinaldi, who now has completed his doctorate, and visiting research assistant Federico Melaccio, Ph.D. both visiting from Italy's Universit di Siena. The models were used to study the activation of the pigments and show that melanopsin light activation is the fastest, and its thermal activation is the slowest, which was expected for maximum light sensitivity.

The computer models of human melanopsin, and bovine and squid rhodopsins, provide further support for a theory reported by the LCPP group in the September 2012 issue of Science Magazine which explained the correlation between thermal noise and perceived color, a concept first proposed by the British neuroscientist Horace Barlow in 1957. Barlow suggested the existence of a link between the color of light perceived by the sensor and its thermal noise and established that the minimum possible thermal noise is achieved when the absorbing light has a wavelength around 470 nanometers, which corresponds to blue light.

"This wavelength and corresponding bluish color matches the wavelength that has been observed and simulated in the LCPP lab," said Olivucci. "In fact, our calculations also indicate that a shift from blue to even shorter wavelengths (i.e. indigo and violet) will lead to an inversion
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Contact: Mr. Jamie Abel
jabel@oh-tech.org
614-292-6495
Ohio Supercomputer Center
Source:Eurekalert  

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