Navigation Links
Computer modeling technique goes viral at Brandeis
Date:6/18/2013

It's not a hacker lab. At Brandeis University, sophisticated computational models and advances in graphical processing units are helping scientists understand the complex interplay between genomic data, virus structure and the formation of the virus' outer "shell" critical for replication.

"We hope that some of what we are finding will help researchers alter virus assembly, leaving viruses unable to replicate," says post-doctoral fellow Jason Perlmutter, first author of the scientific paper describing the technique, published in the open access journal eLife.

Scientists know that many viruses are able to hijack the genetic machinery of host cells to produce copies of themselves and spread infection from cell to cell. For many virus families, a key part of this process is the formation of a protein "shell," called a capsid, around the viral genome during the assembly process.

The physics of this assembly process, which involves interactions between the negatively charged nucleic acid genome and the positively charged capsid protein, depends on a number of factors related to the structure of the virus genome.

"Changing all these critical genomic parameters in a live virus and looking at how capsid formation behaves is impossible given the speed of the process and our current imaging techniques," says associate professor of physics Michael Hagan, whose lab conducted the study.

That's why the team's modeling approach the most realistic developed to date is so important to scientists who are interested in how the virus capsid protein assembles around its genome in the cell. The Brandeis team used their modeling tool to calculate the optimal genome for a number of specific capsids which vary in size, shape and surface properties.

"If you take the model and apply it to biological viruses, we are able to predict within a narrow range key structural features of the virus genome and, by extension, ho
'/>"/>

Contact: Ellen de Graffenreid
edegraff@brandeis.edu
781-736-4213
Brandeis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computer simulations help explain why HIV cure remains elusive
2. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
3. Computer scientists develop an interactive field guide app for birders
4. Computer model pinpoints prime materials for efficient carbon capture
5. 2 NASA visualizations selected for computers graphics showcase
6. RIKEN and Fujitsu complete operational testing of the K computer
7. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
8. Computers can predict effects of HIV policies
9. Eco-computer with a natural wood look
10. Molecular economics: New computer models calculate systems-wide costs of gene expression
11. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... bonds are produced naturally across all kingdoms of life ... a broad range of biological activities. The presence of ... influence on their molecular properties. , One ... to find the late-stage, site-specific incorporation of a halogen ... sp C-H bond (one of the most inert chemical ...
(Date:9/15/2014)... coral reef ecologists fears that reef biodiversity may not ... we once thought. , In an international study published ... Excellence for Coral Reef Studies (Coral CoE) says we ... within reef ecosystems. , In coral reefs, just as ... keep the ecosystem safe and functioning. , Professor ...
(Date:9/15/2014)... assistant professor in the Department of Science and Technology ... Human Sciences at Virginia Tech, has won a 2014 ... study the prospects and problems of creating a global ... Japan,s Fukushima I Nuclear Power Plant in March 2011 ... viewed nuclear emergencies, Schmid said. Three of the plant,s ...
Breaking Biology News(10 mins):Pitt chemical biologist finds new halogenation enzyme 2Specialized species critical for reefs 2'Nuclear disasters don't respect national boundaries' 2
... wrinkles and hide those pesky grays, but what about ... fix, such as losing muscle mass? Cutting calories early ... the phenomenon in rats. A restricted-calorie diet, ... mitochondrial mishap that may contribute to muscle loss in ...
... This press release is available in French . ... Research Institute of the Jewish General Hospital along with ... Research Institute (OHRI) report a significant breakthrough in the use ... known as oncolytic virotherapy. Their results were published in the ...
... to see a single molecule inside a living cell. ... helping to develop a new technique that will enable ... unprecedented look at the atomic structure of cellular molecules. ... the country and in Germany and Sweden to utilize ...
Cached Biology News:Cutting calories could limit muscle wasting in later years 2Cutting calories could limit muscle wasting in later years 3Viral 'magic bullet' targets cancer cells with help of new compound 2Improving our ability to peek inside molecules 2
(Date:9/15/2014)... of carbon nanotubes is neat, but Rice University scientists are ... in new fibers created at Rice line up like a ... Angel Mart and his colleagues. , The tricky bit, according ... the journal ACS Nano , is keeping the densely ... , Left to their own devices, carbon nanotubes form clumps ...
(Date:9/15/2014)... , Sept. 15, 2014 Research and ... Exome Sequencing Market by Product, by Services, by Technology, by ... offering. Whole Exome Sequencing (WES) is next-generation ... genome, i.e. the exon. The exome, which is the total ... the total genome and is actually converted into proteins after ...
(Date:9/15/2014)... septiembre de 2014 La segunda anual International ... 12 al 18 de octubre. Como iniciativa conjunta de la ... compañías miembro s, la IPAW se ha diseñado para: ... a la colección de fuentes de plasma , Reconocimiento ... y mejorar las vidas , Aumento del conocimiento sobre ...
(Date:9/14/2014)... survival strategies. They often create a biofilm to protect ... with antibiotics. A biofilm is a bacterial community that ... sugar chains and "curli". Scientists at VIB and ... a detailed three-dimensional image of the pores through which ... a crucial step in the formation of the protective ...
Breaking Biology Technology:Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3La International Plasma Awareness Week será una celebración para los donantes 2La International Plasma Awareness Week será una celebración para los donantes 3New insights in survival strategies of bacteria 2
... Corp . is now using radio frequency identification (RFID) ... the world's largest manufacturer of cordless telephones. , ,RFID ... to engage the supply chain management technology, according to ... integrate passive RFID technology into its supply chain environment. ...
... - Alfalight, Inc., announced the release of ... two configurations for delivery in September. , ,The CPM-II is ... (0.22 NA) output fiber for fiber laser applications. A version ... micron signal/pump fiber) is also available for fiber amplifier and ...
... week before Badger football begins its 2005 season, researchers at ... way to demonstrate their school spirit. The only fans who ... , ,Last month a team of UW-Madison chemists led by ... the university's mascot made of nanofiber hairs each only 75 ...
Cached Biology Technology:Nanotechnology minimizes UW's beloved mascot 2
... your microarray data using Asuragens bioinformatics ... need from consultation to extensive data ... date methods. Utilize our expertise in ... Service or from your own microarray ...
... value of your microarray data using ... support you need from consultation to ... up to date methods. Utilize our ... Expression Profiling Service or from your ...
... Maximize the value of your microarray ... the support you need from consultation to ... to date methods. Utilize our expertise in ... or from your own microarray experiments., ,Normalization ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
Biology Products: