Navigation Links
Computational model examines the pathways of Alzheimer's that strikes at the young
Date:4/17/2009

NEW ORLEANSAlzheimer's disease (AD) is a tragic disease that robs an individual of their memory and mental capacity. One in eight people over the age of 65 now suffer from the disease and one in two people over 85 are diagnosed with the disease. Contrary to popular belief, Alzheimer's does not only affect the elderly. Familial Alzheimer's disease (FAD), an offshoot of the disease, affects those as young as 30.

The Study

Alzheimer's is a complex disease, and so too are the attempts to explain it. One way to understand how the brain works to cause the disorder is by using computational modeling, (a series of equations) to characterize an individual aspect that is important to the disease. Biomedical engineers Lydia S. Glaw and Thomas C. Skalak, Ph.D., of the Department of Biomedical Engineering, University of Virginia, Charlottesville, have created a model to examine the role of certain proteins in the development of the disease. Their findings are contained in the study entitled A Computational Model of the Role of Presenilin-1 and Glycogen Synthase Kinase-3 in Familial Alzheimer's Disease. They will present their findings at the 122nd Annual Meeting of the American Physiological Society (APS; www.the-aps.org/press), which is part of the Experimental Biology 2009 scientific conference. The meeting will be held April 18-22, 2009 in New Orleans.

The researchers constructed a simple computational model to measure plaques and tangles and their influence in causing FAD. The model tested the hypothesis that certain variablesgenetic mutations in proteins and "tau" tanglesmight be predicative of the development of the disease. The main hypothesis that the model tested was the idea that GSK3 is a link between amyloid beta buildup and tau tangle development.

Brain Plaque: A Major Instigator?

The proteins presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids that are found in large quantity in AD) were studied to quantitatively examine their roles in the development of Alzheimer's pathology. The elements (in the form of existing research data) were applied to the model, which was constructed of kinetic equations developed from literature searches, and analyzed the interactions of the proteins and complexes under various scenarios. The model is a first-of-its-kind approach to modeling, understanding and predicting Alzheimer's pathways.

Results: No Link Between A Protein and Plaques, Tangles

GSK3 had a large effect on tangle formation, but very little on the plaques. Activating GSK3 was not found to be sufficient to cause changes in the brain to the extent seen in Alzheimer's patients. However, overproduction of GSK3 as opposed to activation may be able to cause those changes. Nor was there any link found between amyloid beta plaque and tau tangles. The main conclusion of the model so far is that no single change to the system can cause Alzheimer's disease. Multiple changes, such as a PS1 mutation combined with GSK3 over-activation can, however. A multi-pronged approach to treating the disease may be best.

Conclusion

Glaw's model can be used for additional pathway analysis. She views modeling as a useful way for better understanding this complex, multi-layered disease.


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
703-967-2751
American Physiological Society
Source:Eurekalert

Related biology news :

1. Computational actinide chemistry: Are we there yet?
2. Computational mathematical sciences receives NSF grant for undergraduate research
3. Computational biochemist uncovers a molecular clue to evolution
4. Penn presents inaugural symposium on applied mathematics and computational science
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. New computational technique allows comparison of whole genomes as easily as whole books
7. Oxford Journals and the International Society for Computational Biology announce new partnership
8. 7th [BC]2 Basel Computational Biology Conference
9. Computational model examines the pathways of Alzheimers that strikes at the young
10. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
11. A new kind of rat model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)... WASHINGTON , Feb. 13, 2017 Former ... U.S. Senate Judiciary Committee, Janice Kephart of ... regarding President Donald Trump,s "Executive Order: Protecting ... States" (Jan. 27, 2017):  "As President Trump,s ... 9th Circuit has now essentially banned the travel ban, ...
(Date:2/8/2017)... YORK , Feb. 7, 2017 Report Highlights ... The ... should reach $11.4 billion by 2021, growing at a compound ... Includes - An overview of the global markets for synthetic ... 2015, estimates for 2016, and projections of compound annual growth ...
(Date:2/7/2017)... , February 7, 2017 Ipsidy ... Solutions Corporation [OTC: IDGS], ("Ipsidy" or the "Company") a ... transaction processing services, is pleased to announce the following ... Effective January 31, 2017, Philip D. ... Directors, CEO and President.  An experienced payment industry professional ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... February 22, 2017 , ... Park Systems , a leader ... for all SPIE attendees and Park customers on Feb. 27, 2017 ... the San Jose Convention Center. The luncheon will feature a talk on Automated ...
(Date:2/22/2017)... Scientists propose in Nature blocking a molecule ... maybe other lysosomal storage diseases as a possible treatment ... An international research team led by ... investigators from the University of Lübeck in ... study was conducted in mouse models of lysosomal storage ...
(Date:2/22/2017)... ... 2017 , ... ProMIS Neurosciences (“ProMIS” or the “Company”), a ... announced it has issued a scientific white paper entitled “Results from recent Alzheimer’s ... commentaries from ProMIS’s scientific team offering insight into the Company’s product portfolio and ...
(Date:2/22/2017)... ... , ... LabRoots , the leading provider of educational and interactive virtual ... announce the launch of a new scholarship for young scientists seeking a degree in ... is open to all high school seniors, 17 years or older; as well as ...
Breaking Biology Technology: