Navigation Links
Computational microscope peers into the working ribosome
Date:11/23/2009

.

"It is like a cloud that gives you the volume within which you find 90 percent of all the electrons of the system," he said. The clouds capture the ribosome in action, but require computing to reveal chemical detail.

The researchers began by building computerized, atomic-scale models of the ribosome-protein complexes based on the crystal structures of the molecules, and then directed the computer to use this information to "fit" the structures into the electron clouds seen in cryo-EM studies. Simulations tracked the behavior of 2.7 million atoms in the SecY study, making it "the biggest, or one of the biggest, computer simulations to be published so far," Schulten said.

In the first study, the researchers were able to detect the precise molecular maneuvering that allows the ribosome and EF-Tu to recognize and interact with another molecule, transfer-RNA (tRNA). This interaction is key to the successful assembly of proteins because the ribosome and its partners must recognize the tRNA that carries the correct amino acid to be added to the growing protein chain.

The researchers on this study, led by Joachim Frank, of Columbia University (who also provided the cryo-EM data), found structural evidence that when the ribosome recognizes the correct tRNA it induces a change in the shape of EF-Tu. A gate in EF-Tu swings open, allowing a cascade of chemical interactions that lead to the addition of the amino acid to the protein.

The second study provided robust evidence that when the ribosome is translating a membrane protein, or a protein destined for excretion, it hooks up with a single SecY membrane channel shortly after protein translation begins.

The SecY binds to the ribosome by inserting two looped strands into the ribosome's exit channel. This interaction loosens a plug that normally seals the SecY channel. The plug moves out of the way, allowing the ribosome to funnel the growing protein through the membrane c
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Computational actinide chemistry: Are we there yet?
2. Computational mathematical sciences receives NSF grant for undergraduate research
3. Computational biochemist uncovers a molecular clue to evolution
4. Penn presents inaugural symposium on applied mathematics and computational science
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. New computational technique allows comparison of whole genomes as easily as whole books
7. Oxford Journals and the International Society for Computational Biology announce new partnership
8. 7th [BC]2 Basel Computational Biology Conference
9. Computational model examines the pathways of Alzheimers that strikes at the young
10. Computational model examines the pathways of Alzheimers that strikes at the young
11. 7th annual [BC]2 Basel Computational Biology Conference Molecular Evolution June 18-19, 2009
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Computational microscope peers into the working ribosome
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
(Date:10/15/2014)... biophysics textbook and it describes how life functions and ... into biological systems and provides an understanding of the ... how our genes make proteins that control the dynamics ... an organism. It quantifies the principles of life and ... on both large and small scales. The book is ...
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
Breaking Biology News(10 mins):New perspectives for development of an RSV vaccine 2New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... distinguish between the majority of plant species on Earth has ... Proceedings of the National Academy of Sciences journal today (Monday ... to identify plants using a small sample, could lead to ... species-rich areas like rainforests. It could also lead to accurate ...
... In the second space age, human spaceflight may no ... clever engineers are aggressively blazing new trails into the ... space tourism, ultra fast point-to-point earth travel and even ... pm, Perimeter Institute will host science journalist and author ...
... Feb. 4 Material Technologies,Inc. (OTC Bulletin Board: ... inspection firms last week. Company officers and inspectors,attended ... week to learn how to,implement an EFS inspection, ... analysis of the data, and the preparation of ...
Cached Biology News:DNA 'barcode' identified for plants 2DNA 'barcode' identified for plants 3Material Technologies Holds First Electrochemical Fatigue Sensor Training for Private Inspection Firms 2Material Technologies Holds First Electrochemical Fatigue Sensor Training for Private Inspection Firms 3
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and ... analyzes the global market on the basis of ... details such as the key drivers, current trends ... Browse 81 Market Data Tables and 29 Figures ... “1,6-Hexanediol Market by Application and by Geography - ...
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market report defines ... forecast of revenue. The electronic medical record market in the ... 2018, at a CAGR of 9.4% from 2013 to 2018. ... Record (EMR) market, to get an idea of the in-depth ... of the market in the same region, and is supported ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market by Product ... Research Center, Physician Office, Nursing Homes), by Lead ... provides a detailed overview of the major drivers, ... impacting the global diagnostic ECG market along with ... share analysis. , The global diagnostic ECG market ...
(Date:10/17/2014)... 2014 For the seventh consecutive ... published in today’s print issue of Science magazine. ... Employers Survey polled employees in the biotechnology, pharmaceutical ... employers. Rankings were determined based on responses ... their companies on 23 characteristics, including financial strength, ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... With Another Antidepressant Can Help Adults Living With ... Adequate Symptom Relief -(1), PRINCETON, N.J. and ... BMY ) and Otsuka Pharmaceutical Co.,Ltd. announced today ... the supplemental New Drug Application for ABILIFY(R),(aripiprazole) as ...
... HD*PET, Symbia(R) TruePoint(TM) SPECT-CT and Symbia E ... Nov. 20 From,innovative new product solutions ... Solutions (http://www.usa.siemens.com/medical ) is,propelling the field ... across,clinical areas, including oncology, neurology and cardiology, ...
... ET on November 27, 2007, CAMBRIDGE, Mass., Nov. ... announced its participation,in the Lazard Capital Markets Fourth Annual ... the New York Palace Hotel in New York,City. Mark ... presenting at 2:00 pm ET on Tuesday, November 27, ...
Cached Biology Technology:U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 2U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 3U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 4U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 5U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 6U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 7U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 8U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 9Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 2Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 3Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 4Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 5Targanta to Present at Lazard Capital Markets Fourth Annual Healthcare Conference 2
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
... to Yersinia pestis This antibody ... . Immunogen: Purified ... vaccine strain EV76. ... F1 capsular antigen. There is no ...
Phospho-SEK1/MKK4 (Thr261) Antibody...
Rabbit polyclonal to Leucyl tRNA synthetase ( Abpromise for all tested applications). Antigen: L930-H1176 denatured human recombinant LRS. Entrez Gene ID: 3926 Swiss Protein ID: Q9P2J5...
Biology Products: