Navigation Links
Computational biology: Cells reprogrammed on the computer
Date:7/31/2013

0. Biologists add refined cocktails of molecules, i.e. growth factors, to the cell cultures in a certain order. This allows them to control the genetic activity in the conversion process. However, this method so far has been largely guided by educated trial and error.

Variable jumping between different cell lines is possible

Now, the LCSB researchers have replaced trial and error with computer calculations, as computer scientist and PhD student at LCSB Isaac Crespo explains: "Our theoretical model first queries databases where vast amounts of information on gene actions and their effects are stored and then identifies the genes that maintain the stability of differentiated cells. Working from the appropriate records, the model suggests which genes in the starting cells need to be switched on and off again, and when, in order to change them into a different cell type."

"Our predictions have proved very accurate in the lab," says Professor del Sol: "And it turns out it makes no difference at all how similar the cells are. The models work equally well for cell lines that have only just branched off from one another as for those that are already very far apart." Prof. del Sol's and Crespo's model thus allows highly variable jumping between very different cell types without taking a detour via stem cells.

The biologists and medical scientists still have their lab work cut out for them: They have to identify all the growth factors that initiate the respective genetic activities in the correct, predicted order.


'/>"/>

Contact: Britta Schlüter
britta.schlueter@uni.lu
352-466-644-6563
University of Luxembourg
Source:Eurekalert

Page: 1 2

Related biology news :

1. GW announces creation of Computational Biology Institute to conduct integrated research
2. George Washington University Computational Biology Director solves 200-year-old oceanic mystery
3. A new computational method for timing the tree of life
4. Using computational biology for the annotation of proteins
5. Kirk, Spock together: Putting emotion, logic into computational words
6. Collaboration to establish new computational resources for metabolomics
7. New research projects to enhance bioinformatics and computational biology tools and methodologies
8. Infection biology: The elusive third factor
9. The Quarterly Review of Biology: Why some fats are worse than others
10. FASEB SRC announces conference registration open for: Melatonin Biology: Actions & Therapeutics
11. Developmental neurobiology: How the brain folds to fit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
(Date:4/17/2014)... in bone marrow need to produce hydrogen sulfide in ... to a new study from the Center for Craniofacial ... of USC. , Professor Songtao Shi, principal investigator on ... by the cells governs the flow of calcium ions. ... that results in osteogenesis, or the creation of new ...
(Date:4/17/2014)... parasites and pathogens that devastate honeybees in Europe, Asia ... but do not appear to be impacting native honeybee ... of researchers., The invasive pests include including Nosema ... African honeybees appear to be resilient to these invasive ... to control pests in Europe, Asia and the United ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... New Mexico, July 20, 2011Researchers at the U.S. Department ... Bioenergy Research Center have found a potential key for ... as corn leaves and stalks, or switch grass. ... the American Chemical Society , Los Alamos researchers S. ...
... another major step in sleuthing the 2010 Deepwater Horizon oil ... Institution (WHOI) determined what chemicals were contained in a deep, ... long. The scientists mapped and sampled it last summer ... the Deepwater Horizon oil spill. The researchers took a ...
... The Bureau of Reclamation and Fluid Imaging Technologies ... to improve the capacity and speed of Fluid Imaging ... zebra mussel larvae in water samples. The spread ... potential to impair or interrupt water delivery and hydropower ...
Cached Biology News:Researchers find potential key for unlocking biomass energy 2Chemical make-up of Gulf of Mexico plume determined 2Chemical make-up of Gulf of Mexico plume determined 3Chemical make-up of Gulf of Mexico plume determined 4Reclamation signs research agreement to improve quagga and zebra mussel larvae detection 2
(Date:1/15/2014)... More than 5 million Americans are currently living ... will die with Alzheimer’s or another dementia, according to ... many Americans into looking for ways to improve their ... cognitive disorders. Jonathan Weisman, president of Biohack Pure, is ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... The 2012 federal budget recommends the allocation of ... federal interagency research and development program that studies the ... nanoscale—a measurement of particles between 1 and 100 nanometers ... materials are found in nature as part of smoke, ...
... Metabolex, Inc., a biopharmaceutical company focused on the ... treatment of metabolic diseases, announced today that it has ... its product candidate for the management of hyperuricemia in ... study will evaluate the safety and urate-lowering activity of ...
... Ontario Institute for Cancer Research (OICR) today announced ... bringing promising anticancer technologies to market. ... bring commercial and operational leadership that will accelerate ... assets," said Frank Stonebanks, Vice-President, Commercialization and Chief ...
Cached Biology Technology:Environmental Training Center Prepares Companies to Handle Nanotechnology Environmental and Human Safety Impacts 2Metabolex Initiates Phase 2 Trial of Arhalofenate 2Ontario Institute for Cancer Research Announces Spin Off Companies Developing Promising Anticancer Technologies 2Ontario Institute for Cancer Research Announces Spin Off Companies Developing Promising Anticancer Technologies 3
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... Staccato Mini-Workstations provide fast and ... genomics, proteomics and drug development laboratories. ... of instrumentation to automate basic liquid ... Mini-Workstations are controlled with either Caliper's ...
Experion StdSens chips are the microfluidic chips used to perform standard-sensitivity RNA analysis (nanogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to...
... submicron range are part of your production ... of particle size is important to you. ... detect the component populations in your sample ... Analyzer uses Photon Correlation Spectroscopy (PCS) , ...
Biology Products: