Navigation Links
Computational biology: Cells reprogrammed on the computer
Date:7/31/2013

0. Biologists add refined cocktails of molecules, i.e. growth factors, to the cell cultures in a certain order. This allows them to control the genetic activity in the conversion process. However, this method so far has been largely guided by educated trial and error.

Variable jumping between different cell lines is possible

Now, the LCSB researchers have replaced trial and error with computer calculations, as computer scientist and PhD student at LCSB Isaac Crespo explains: "Our theoretical model first queries databases where vast amounts of information on gene actions and their effects are stored and then identifies the genes that maintain the stability of differentiated cells. Working from the appropriate records, the model suggests which genes in the starting cells need to be switched on and off again, and when, in order to change them into a different cell type."

"Our predictions have proved very accurate in the lab," says Professor del Sol: "And it turns out it makes no difference at all how similar the cells are. The models work equally well for cell lines that have only just branched off from one another as for those that are already very far apart." Prof. del Sol's and Crespo's model thus allows highly variable jumping between very different cell types without taking a detour via stem cells.

The biologists and medical scientists still have their lab work cut out for them: They have to identify all the growth factors that initiate the respective genetic activities in the correct, predicted order.


'/>"/>

Contact: Britta Schlüter
britta.schlueter@uni.lu
352-466-644-6563
University of Luxembourg
Source:Eurekalert

Page: 1 2

Related biology news :

1. GW announces creation of Computational Biology Institute to conduct integrated research
2. George Washington University Computational Biology Director solves 200-year-old oceanic mystery
3. A new computational method for timing the tree of life
4. Using computational biology for the annotation of proteins
5. Kirk, Spock together: Putting emotion, logic into computational words
6. Collaboration to establish new computational resources for metabolomics
7. New research projects to enhance bioinformatics and computational biology tools and methodologies
8. Infection biology: The elusive third factor
9. The Quarterly Review of Biology: Why some fats are worse than others
10. FASEB SRC announces conference registration open for: Melatonin Biology: Actions & Therapeutics
11. Developmental neurobiology: How the brain folds to fit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... MINNETONKA, Minn. , June 23, 2015 /PRNewswire/ ... technology company that supports the entire spectrum of ... iMedNet ™ , the company,s ... has been awarded a Silver 2015 Stevie® Award ... the Health Products & Services Website category.  The ...
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market announces that its ... segment on "Money on the Mark", scheduled to air on ... June 20 th . The broadcast ... from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino ...
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - handyem ... centralized around the incorporation of handyem,s HPC-150 portable ... laboratory, the Mo-POD™. This unprecedented model of mobile ... Conference at the Pennsylvania ... June 15 th to 18 th ...
Breaking Biology News(10 mins):MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3
... Calif. -- The National Institutes for Health (NIH) have ... researchers to engineer an artificial pancreas system that will ... in behavior and physiology. This collaboration between physicians and ... 1 diabetes management human behavior, physiology, and medical ...
... Southern Research Station (SRS) today announced the publication of a ... native bark beetle that impacts both the economic and ecological ... Southern pine beetle is the most destructive forest pest ... in damage and lost timber income annually. The most recent ...
... of genetics, lifestyle and environment on breast cancer in ... of Louisville School of Public Health & Information Sciences ... Denkhoff. Through a SPHIS Department of Epidemiology ... grant from Susan G. Komen for the Cure, the ...
Cached Biology News:NIH awards group $4.5 million for smart artificial pancreas technology 2NIH awards group $4.5 million for smart artificial pancreas technology 3'Southern Pine Beetle II' 2UofL students seek answers to breast cancer disparities in minority populations 2UofL students seek answers to breast cancer disparities in minority populations 3
(Date:7/3/2015)... July 3, 2015 ... verkossa osoitteessa  http://www.openinnovationinscience.at Wienissä ... in Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... (LBG) tekemän, kansainvälisiä tutkijoita ja ... kaksi suurinta haastetta ovat kannustimien ...
(Date:7/3/2015)... Forskere kan søke ... Science", som finner sted i ... på  http://www.openinnovationinscience.at , og søknadsperioden varer frem ... to største utfordringene innen helsevitenskapen er mangelen ... og kompleksiteten av nåværende forskningsresultater, i følge ...
(Date:7/2/2015)... GLEN ELLYN, Ill. , July 2, 2015 /PRNewswire-USNewswire/ ... and Colton Eakins are gaining invaluable real-world ... Institute of Technology this summer. The students ... Dr. Jeff Wereszczynski,s research group at IIT. ... Professors Dr. Tom Carter , Physics; Dr. ...
(Date:7/2/2015)... Memphis, TN (PRWEB) , ... July 02, 2015 ... ... in the development and manufacturing of surgical instruments in Orthopedics, announced today the ... orthopedic contract-manufacturing and the world's largest provider of surgical instruments to the Spine ...
Breaking Biology Technology:Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3COD Students Participate in Prestigious Summer Internships 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3
... Investigator Sites Now Available on goBalto.com , ... ... goBalto, an online drug development partnering site for the pharmaceutical ... is making its proprietary list of India-based Investigator Sites and ...
... - Completed Series B Total ... Opsona Therapeutics, a biotechnology company focused on novel therapeutic,and ... Roche Venture Fund and Enterprise Ireland have committed an,additional ... February,this year, bringing the total round to EUR21.3 million. ...
... May 18 Cell Therapeutics, Inc. (the "Company" or "CTI") ... its "Modified Dutch Auction" tender offer (the "Exchange Offer") to ... of its common stock, no par value (the "Common Stock"), ... principal amount of the following outstanding series of its convertible ...
Cached Biology Technology:goBalto Partners with Maya Clinicals to Expand Its List of Investigator Sites 2goBalto Partners with Maya Clinicals to Expand Its List of Investigator Sites 3Roche Venture Fund, Enterprise Ireland Commit EUR3.3 M to Opsona Series B Financing 2Roche Venture Fund, Enterprise Ireland Commit EUR3.3 M to Opsona Series B Financing 3Cell Therapeutics Amends 'Modified Dutch Auction' Tender Offer for up to $89.2 million of Its Outstanding Convertible Notes 2Cell Therapeutics Amends 'Modified Dutch Auction' Tender Offer for up to $89.2 million of Its Outstanding Convertible Notes 3Cell Therapeutics Amends 'Modified Dutch Auction' Tender Offer for up to $89.2 million of Its Outstanding Convertible Notes 4Cell Therapeutics Amends 'Modified Dutch Auction' Tender Offer for up to $89.2 million of Its Outstanding Convertible Notes 5
...
...
... sensitive and specific detection of microRNAs (miRNAs) ... have high binding affinity and discrimination, enabling ... Due to the high binding affinity of ... the amount of sample is needed compared ...
... Mixes are optimised for SYBR Green I assays ... Quantitative PCR, with the exception of template and ... optimal levels of active SYBR Green I dye ... reaction buffer that enables detection of low copy ...
Biology Products: