Navigation Links
Compromised skin barrier function plays a role in psorasis development
Date:1/25/2009

Researchers at the Genome Institute of Singapore (GIS) and the Anhui Medical University, China, have identified genes that play an important role in the development of psoriasis, a common chronic skin disease.

The research, led by GIS Human Genetics Group Leader and Associate Prof. Liu Jianjun, will be published online on 25 Jan. 2009 in the journal Nature Genetics.

Studying genetic variants in the human genomes of a large cohort of patients with psorasis and healthy controls in the Chinese population, Dr. Liu and his colleagues, who are one of the three independent teams that have been simultaneously performing genetic studies on psoriasis, found that a genetic variant within what is known as the LCE gene cluster is able to provide protection against the development of psoriasis.

One of the LCE genes' functions is to code proteins that are part of cells located in the outermost layers of skin. These proteins are important for maintaining skin's barrier function.

"Together with the findings from the other two studies," said Dr Liu, "our finding suggests that compromised skin barrier function play a role in the development of psoriasis. This is a very important find, as it advances our understanding of the genetic basis of psoriasis, which in turn is important for early diagnosis and prediction of an individual's risk to the disease."

While Dr Liu's team focused on a Chinese population, the other two studies were conducted on Western populations. Dr Liu added, "Our team's work is also important because it is the first study ever done on a Chinese population all other studies on psoriasis so far have focused on western populations."

All three independent studies will be published by Nature Genetics at the same time.

Psoriasis is a common chronic, auto-immune and hyper-proliferative skin disease, usually characterized by red scaly patches on the skin. Affecting about one percent of individuals, it is a recurring condition with varying degrees of severity from minor localised patches to complete body coverage.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. Text focuses on diagnosing infections in immunocompromised patients
3. Auto immune response creates barrier to fertility; could be a step in speciation
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Scientists from the UGR prove that rivers do not act as barriers for groundwater flow
6. Building the blood-brain barrier
7. Fear of hypoglycemia a barrier to exercise for type 1 diabetics
8. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
9. Device helps patients survive, regain function til transplant
10. Specific brain protein required for nerve cell connections to form and function
11. Systems Biology poised to revolutionize the understanding of cell function and disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
Breaking Biology Technology: