Navigation Links
Compromised skin barrier function plays a role in psorasis development
Date:1/25/2009

Researchers at the Genome Institute of Singapore (GIS) and the Anhui Medical University, China, have identified genes that play an important role in the development of psoriasis, a common chronic skin disease.

The research, led by GIS Human Genetics Group Leader and Associate Prof. Liu Jianjun, will be published online on 25 Jan. 2009 in the journal Nature Genetics.

Studying genetic variants in the human genomes of a large cohort of patients with psorasis and healthy controls in the Chinese population, Dr. Liu and his colleagues, who are one of the three independent teams that have been simultaneously performing genetic studies on psoriasis, found that a genetic variant within what is known as the LCE gene cluster is able to provide protection against the development of psoriasis.

One of the LCE genes' functions is to code proteins that are part of cells located in the outermost layers of skin. These proteins are important for maintaining skin's barrier function.

"Together with the findings from the other two studies," said Dr Liu, "our finding suggests that compromised skin barrier function play a role in the development of psoriasis. This is a very important find, as it advances our understanding of the genetic basis of psoriasis, which in turn is important for early diagnosis and prediction of an individual's risk to the disease."

While Dr Liu's team focused on a Chinese population, the other two studies were conducted on Western populations. Dr Liu added, "Our team's work is also important because it is the first study ever done on a Chinese population all other studies on psoriasis so far have focused on western populations."

All three independent studies will be published by Nature Genetics at the same time.

Psoriasis is a common chronic, auto-immune and hyper-proliferative skin disease, usually characterized by red scaly patches on the skin. Affecting about one percent of individuals, it is a recurring condition with varying degrees of severity from minor localised patches to complete body coverage.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. Text focuses on diagnosing infections in immunocompromised patients
3. Auto immune response creates barrier to fertility; could be a step in speciation
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Scientists from the UGR prove that rivers do not act as barriers for groundwater flow
6. Building the blood-brain barrier
7. Fear of hypoglycemia a barrier to exercise for type 1 diabetics
8. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
9. Device helps patients survive, regain function til transplant
10. Specific brain protein required for nerve cell connections to form and function
11. Systems Biology poised to revolutionize the understanding of cell function and disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... 2017 , ... Third Wave Bioactives, LLC announces the addition of Brett Thompson. ... business development and ensuring quality customer experience. , Brett brings to Third ... technical, marketing and sales roles. “Brett’s background working with customers and eye for market ...
(Date:6/23/2017)... CARDIFF, UK (PRWEB) , ... June 23, 2017 , ... ... Brian Lula, president of Physik Instrumente USA, have been selected as this year’s recipients ... . , The two have been invited along with other honorees to accept their ...
(Date:6/22/2017)... ... 2017 , ... Building on the success of the inaugural RAADfest last year, ... latest developments in radical life extension. RAADfest combines cutting edge science presented for a ... personal development, making it the largest most comprehensive and inclusive super longevity event in ...
(Date:6/22/2017)... ... 22, 2017 , ... The first human cell line HeLa, established in 1951, ... on cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination ... labs and is associated with dramatic consequences for research. , In this educational ...
Breaking Biology Technology: