Navigation Links
Compromised skin barrier function plays a role in psorasis development
Date:1/25/2009

Researchers at the Genome Institute of Singapore (GIS) and the Anhui Medical University, China, have identified genes that play an important role in the development of psoriasis, a common chronic skin disease.

The research, led by GIS Human Genetics Group Leader and Associate Prof. Liu Jianjun, will be published online on 25 Jan. 2009 in the journal Nature Genetics.

Studying genetic variants in the human genomes of a large cohort of patients with psorasis and healthy controls in the Chinese population, Dr. Liu and his colleagues, who are one of the three independent teams that have been simultaneously performing genetic studies on psoriasis, found that a genetic variant within what is known as the LCE gene cluster is able to provide protection against the development of psoriasis.

One of the LCE genes' functions is to code proteins that are part of cells located in the outermost layers of skin. These proteins are important for maintaining skin's barrier function.

"Together with the findings from the other two studies," said Dr Liu, "our finding suggests that compromised skin barrier function play a role in the development of psoriasis. This is a very important find, as it advances our understanding of the genetic basis of psoriasis, which in turn is important for early diagnosis and prediction of an individual's risk to the disease."

While Dr Liu's team focused on a Chinese population, the other two studies were conducted on Western populations. Dr Liu added, "Our team's work is also important because it is the first study ever done on a Chinese population all other studies on psoriasis so far have focused on western populations."

All three independent studies will be published by Nature Genetics at the same time.

Psoriasis is a common chronic, auto-immune and hyper-proliferative skin disease, usually characterized by red scaly patches on the skin. Affecting about one percent of ind
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. Text focuses on diagnosing infections in immunocompromised patients
3. Auto immune response creates barrier to fertility; could be a step in speciation
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Scientists from the UGR prove that rivers do not act as barriers for groundwater flow
6. Building the blood-brain barrier
7. Fear of hypoglycemia a barrier to exercise for type 1 diabetics
8. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
9. Device helps patients survive, regain function til transplant
10. Specific brain protein required for nerve cell connections to form and function
11. Systems Biology poised to revolutionize the understanding of cell function and disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... April 2, 2015 In ... by far outperforms the strongest competitors, showing outstanding ... accuracy, the system is capable of a throughput ... proves up to be ten times faster than ... runner-up performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... 2013) In a study of older mice, wolfberries appear ... against the flu virus. The research, led by scientists at ... (USDA HNRCA) at Tufts University, suggests the wolfberry may increase ... in the ability of the immune system to defend against ...
... It takes dozens of chemical reactions for a cell to ... type of living organism. Cholesterol, for example, an important component ... The molecule that gives oranges their citrusy smell and taste ... Now, researchers at the Salk Institute have discovered ...
... Ariz. To protect themselves, some animals rapidly ... change colors in unusual ways when they interact ... discovered that these color changes don,t happen "out-of-the-blue" ... during important social interactions. For example, when ...
Cached Biology News:Older mice fed wolfberries show reduced risk for flu virus with vaccine 2Missing molecule in chemical production line discovered 2Missing molecule in chemical production line discovered 3ASU researchers discover chameleons use colorful language to communicate 2
(Date:4/17/2015)... , April 17, 2015  US-Australian drug discovery ... a Memorandum of Understanding with the Feinstein Institute ... New York to collaborate with the ... The collaboration brings together the drug ... clinical expertise of the Feinstein Institute in neurosciences ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 LC ... proteomics technologies, announced today that it is seeking ... an innovative multiplex PCR based targeted sequencing technology. ... sequence analysis, that enables accurate detection of rare ... and Omega-Primer™ technologies. The company will collaborate with ...
(Date:4/16/2015)... Spirax Sarco, the leader in ... newly designed, state-of-the-art website in the first quarter ... promotes the Spirax Sarco brand, company capabilities, and ... a site visitor might be looking for including ... serviced, the latest company news, careers, and much ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Spirax Sarco website has a new look 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3
... TUESDAY, NOVEMBER 4, 2008, SAN DIEGO, Oct. 27 ... that Kevin Gorman, President and Chief,Executive Officer of Neurocrine ... Conference in New York., The live presentation takes ... (ET) /7:00 a.m. Pacific Time (PT). The presentation will,be ...
... Pa., Oct. 27 BioTrends Research Group, Inc. ... privately-held businesses in,the Philadelphia region by the Philadelphia ... Development Center, the Entrepreneurs, Forum of,Greater Philadelphia, and ... verifiable revenue growth., "This recognition is a ...
... 27 Osteotech, Inc.,(Nasdaq: OSTE ) announced ... 2008 financial results will be released Friday, November ... Sam Owusu-Akyaw, President and,Chief Executive Officer, as well ... 7, 2008, at 9:00 a.m. Eastern time. You ...
Cached Biology Technology:Neurocrine Biosciences to Present at the Oppenheimer 19th Annual Healthcare Conference 2
... steel with stove enamel coated (RAL 7035 grey) ... Front, back and side windows 6 ... Internal adjustable tempered glass shelf ... Lighting 600 lux AC ...
...
... glass slide in this set of ... in triplicate, for a total of ... proteins as internal control. Antibodies belonging ... angiogenesis, apoptosis, cell cycle progression, signal ...
...
Biology Products: