Navigation Links
Compromised skin barrier function plays a role in psorasis development
Date:1/25/2009

Researchers at the Genome Institute of Singapore (GIS) and the Anhui Medical University, China, have identified genes that play an important role in the development of psoriasis, a common chronic skin disease.

The research, led by GIS Human Genetics Group Leader and Associate Prof. Liu Jianjun, will be published online on 25 Jan. 2009 in the journal Nature Genetics.

Studying genetic variants in the human genomes of a large cohort of patients with psorasis and healthy controls in the Chinese population, Dr. Liu and his colleagues, who are one of the three independent teams that have been simultaneously performing genetic studies on psoriasis, found that a genetic variant within what is known as the LCE gene cluster is able to provide protection against the development of psoriasis.

One of the LCE genes' functions is to code proteins that are part of cells located in the outermost layers of skin. These proteins are important for maintaining skin's barrier function.

"Together with the findings from the other two studies," said Dr Liu, "our finding suggests that compromised skin barrier function play a role in the development of psoriasis. This is a very important find, as it advances our understanding of the genetic basis of psoriasis, which in turn is important for early diagnosis and prediction of an individual's risk to the disease."

While Dr Liu's team focused on a Chinese population, the other two studies were conducted on Western populations. Dr Liu added, "Our team's work is also important because it is the first study ever done on a Chinese population all other studies on psoriasis so far have focused on western populations."

All three independent studies will be published by Nature Genetics at the same time.

Psoriasis is a common chronic, auto-immune and hyper-proliferative skin disease, usually characterized by red scaly patches on the skin. Affecting about one percent of individuals, it is a recurring condition with varying degrees of severity from minor localised patches to complete body coverage.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. Text focuses on diagnosing infections in immunocompromised patients
3. Auto immune response creates barrier to fertility; could be a step in speciation
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Scientists from the UGR prove that rivers do not act as barriers for groundwater flow
6. Building the blood-brain barrier
7. Fear of hypoglycemia a barrier to exercise for type 1 diabetics
8. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
9. Device helps patients survive, regain function til transplant
10. Specific brain protein required for nerve cell connections to form and function
11. Systems Biology poised to revolutionize the understanding of cell function and disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... , March 14, 2016 NXTD ) ... mobile commerce market, announces the airing of a new series ... the week of March 21 st .  The commercials will ... its popular Squawk on the Street show. --> ... the growing mobile commerce market, announces the airing of a ...
(Date:3/10/2016)... Pa. , March 10, 2016   Unisys Corporation ... Customs and Border Protection (CBP) is testing its biometric ... San Diego to help identify certain non-U.S. ... . The test, designed to help determine the efficiency ... environment, began in February and will run until May 2016. ...
(Date:3/3/2016)... -- FlexTech, a SEMI Strategic Association Partner, awarded five FLEXI ... Leadership in Education, and, in a category new this ... year of the FLEXI Awards and the winners join ... past years . Judging was done on a set ... by a panel of non-affiliated, independent, industry experts. ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... Leading CEOs from biotech, ... 31st and June 1st at The Four Seasons Hotel Boston. , The Boston ... sciences, offering exclusive access to key decision makers who influence deal making and ...
(Date:5/3/2016)... THE WOODLANDS, Texas , May 3, 2016 /PRNewswire/ ... board certified plastic surgeon in The Woodlands, ... technology that destroys 24 percent of treated fat cells ... men and woman. Close to 90 percent of Americans ... effective treatment options. Nonsurgical fat reduction procedures are a ...
(Date:5/2/2016)... ... ... StarNet Communications Corp, ( http://www.starnet.com/ ) a leading publisher of remote Linux ... to its flagship X-Win32 PC X server. The new modules enable X-Win32 to ... over encrypted SSH. , Traditionally, users of PC X servers deploy the XDMCP protocol ...
(Date:4/29/2016)... April 29, 2016 According ... Market Research "Separation Systems for Commercial Biotechnology Market ... and Forecast 2015 - 2023", the separation systems ... 10,665.5 Mn in 2014 and is projected to ... to 2023 to reach US$ 19,227.8 Mn in ...
Breaking Biology Technology: