Navigation Links
Comprehensive look at rare leukemia finds relatively few genetic changes launch disease
Date:7/27/2009

g's laboratory.

For this study, researchers analyzed leukemia cells from 111 St. Jude AML patients representing the seven most common subtypes of the disease. The scientists used several techniques to catalog the changes, including single-nucleotide-polymorphism (SNPs) microarrays to chart genome-wide regions of DNA gain or loss, which are known as copy number alterations (CNAs). To identify point mutations, the researchers also performed DNA re-sequencing of 25 genes that are commonly mutated in adult AML. Point mutations involve a single chemical change in the molecular building blocks of DNA.

The data demonstrated that, in contrast to pediatric acute lymphoblastic leukemia (ALL), AML is characterized by a very low burden of mutations. The researchers found slightly more than two CNAs per AML patient, and less than one point mutation per patient in the genes sequenced. The scientists also reported just 21 percent of AML patients had six or more lesions. By comparison, an earlier St. Jude study reported 77 percent of young ALL patients, a more common cancer, had that much DNA damage. Even more surprising, 34 percent of patients in this study lacked any apparent CNA, and 28 percent of those with a translocation lacked additional DNA abnormalities. Certain chromosomal re-arrangements are known as translocations.

The investigators also found no association between CNAs and patient outcome. Despite the low overall number of lesions in the patients studied, novel recurring regions of genetic alteration were identified that harbor known and potential new cancer genes.

The study also reports cryptic chromosomal translocations in 14 percent of patients in this study who, based on standard testing, appeared to lack such re-arrangements. Cryptic translocations are too small to be detected by conventional testing. Downing said the analysis identified focal CNAs adjacent to genes previously linked to chromosomal translocations. Those genes
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Leading researchers to reveal comprehensive dos and donts for prostate cancer
2. University of Minnesota releases first ever comprehensive report of the health of college students
3. More comprehensive analysis of Klamath River basin needed to aid decision makers
4. U. of I. librarian launches comprehensive Web database of field guides
5. Scientists launch first comprehensive database of human oral microbiome
6. Collaboration between researchers yields more comprehensive portrait of brain cancer
7. First comprehensive genomic study of common cold reveals new treatment targets
8. First comprehensive inventory of life in Antarctica
9. Scientists develop method for comprehensive proteome analysis
10. Comprehensive genetic study paves way for new blood-pressure medicines
11. Uniloc Unveils Industry-First Authentication Technology for Comprehensive Protection of Critical Infrastructure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... Synaptics, Inc. (Nasdaq: SYNA ), the ... members of the executive management team will present to ... Leadership Forum on Tuesday, August 11, 2015 at 1:00 ... the Sonnenalp Resort in Vail, CO. ... information. An audio webcast of the event will be ...
(Date:7/31/2015)... , 31 de julio de 2015 BGI llevará ... www.icg-10.org ) del 22 al 25 de octubre de ... La conferencia celebra su décimo aniversario este año. ... en una de las reuniones anuales más influyentes del ... una de las conferencias científicas más dinámicas, entusiastas y ...
(Date:7/31/2015)... , Chine, 31 juillet 2015 ... www.icg-10.org ) sera organisée par le BGI ... Shenzhen en Chine. ... Depuis son inauguration en 2006, l,ICG est devenue ... dans le domaine des « omiques » et c,est aussi ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... part of the Genome Canada Large-Scale Applied Research Project ... to 16 projects across the country, the researchers in ... with the aim of identifying genes or proteins for ... target cancers and other diseases. The first project, ...
... - New research from the University of Calgary,s Faculty ... diagnosis using an iPhone application with the same accuracy ... technology can be particularly useful in rural medical settings. ... neurologists, regardless of where the physicians and patients are ...
... has revealed how infection by a parasitic fungus dramatically changes ... leonardi ), causing them to become zombie-like and to die ... fungus. The multinational research team studied ants living high up ... research will be published in the BioMed Central open-access journal ...
Cached Biology News:OGI genomics researchers awarded $23 million 2OGI genomics researchers awarded $23 million 3iPhone can diagnose stroke: study 2Zombie ants have fungus on the brain, new research reveals 2
(Date:8/31/2015)... ... August 31, 2015 , ... ... most successful food and beverage processors, equipment manufacturers and leaders in the field ... and industrial weighing and formulation for manufacturers of bakery and snacks; beverages; dairy; ...
(Date:8/30/2015)... England , August 31, 2015 ...   einer Frau   für chirurgische   Behandlung     ... von 7-90   werden für eine   verheerende ... 1200 Frauen behandeln und die Anzahl ausgebildeter Chirurgen in ... Astellas gab heute bekannt, dass  Action on Fistula ...
(Date:8/28/2015)... ... 2015 , ... Proove Biosciences , a commercial and ... Intervention Society’ s 23rd Annual Scientific Meeting (ASM). The ASM event took ... on evidence-based research and clinical application, the event gathered industry thought leaders to ...
(Date:8/28/2015)... ... 28, 2015 , ... Riordan-McKenna Institute founders, stem ... that the use of sterile, dehydrated amniotic tissue AlphaPATCH™ developed by Amniotic ... surgical knee wound. , The case involved a 78-year-old male, who presented with ...
Breaking Biology Technology:METTLER TOLEDO Hosts Food Safety Educational Center at 2015 PROCESS EXPO 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4
... Researchers from A*STAR Singapore took lead roles in a ... during long-term culture of human embryonic stem cells (hESCs). ... Peter Andrews of the University of Sheffield (UK), Paul ... Oh of Singapore,s Bioprocessing Technology Institute (BTI), and Barbara ...
... November 28, 2011 Elsevier ... analytic solutions, today announced that Thomas H. Zajac ... / MEDai provides solutions for providers, health plans ... profiling, regulatory compliance and clinical surveillance to improve ...
... Pelleve™ Wrinkle Reduction System was featured in a live ... Top dermatologist Dr. Ava Shamban of Santa Monica, CA ... first-hand look at how Pelleve works. The treatment produced ... takes to watch the show. A revolutionary, ...
Cached Biology Technology:Singapore scientists lead human embryonic stem cell study 2Singapore scientists lead human embryonic stem cell study 3Elsevier / MEDai Appoints Tom Zajac as New President 2Elsevier / MEDai Appoints Tom Zajac as New President 3Ellman's Pelleve™ Wrinkle Reduction System featured in "Sexy Eyes" segment on The Doctors 2
... random mutations to the gene supplied by a ... a vector of choice to obtain a library ... be set to a desired value within 1-20 ... Mutations can be restricted to a desired ...
... plasmid DNA preparations are prepared from ... from 1mg to multi-gram scales. Each ... needs, and glycerol stocks are maintained ... clonal selection (Clonal selection includes screening ...
... sports 16-independent channels for automated gigaseal patch ... screening against voltage-gated ion channels, such as ... channels. The four pipette heads afford ... ion channel drug discovery. The glass-coated ...
... to be able to handle larger sample volumes, ... well as interface with telemetry systems. The ... with dogs, pigs, and primates. The system ... and the computer can be located outside the ...
Biology Products: