Navigation Links
Comprehensive genetic study paves way for new blood-pressure medicines
Date:5/11/2009

Eight previously unknown genes that affect blood pressure were recently identified in a comprehensive international study comprising 34,433 Europeans. The findings of the study, in which Uppsala University researchers participated, are being presented today in the Web edition of Nature Genetics.

High blood pressure is a major contributing cause of cardiovascular disorders. Previous studies have shown that it is extremely difficult to identify genes that affect blood pressure, partly because blood pressure is impacted by non-genetic factors, such as exercise and intake of salt in food, and partly because there are many genes that work together to affect blood pressure.

In the present study, a concerted effort was made by 93 research teams in 14 countries to find genes that affect blood-pressure levels in healthy individuals. To identify these genes, blood-pressure levels were monitored in those participating in the study, and DNA samples were gathered. The entire human genome was mapped systematically by analyzing the DNA samples with the help of hundreds of thousands of genetic markers, so-called SNP markers. Sweden was represented in the study by three research teams: Ann-Christine Syvnen's research group and the SNP technology platform at Uppsala University, a group from the Karolinska Institute, and a group from Lund University. The study included DNA samples from 2,000 Swedes.

The areas of the genome that were identified in the study contain several genes that probably play a role in regulating blood pressure. The CYP17A1 gene on chromosome 10q24, for instance, plays a key role in the biosynthesis of glucorticoid hormones, which influence the metabolism of salt. In another area on chromosome 1p36 there are genes for two peptides with natrium-expelling effects. A lesser-known gene in this area, CLCN6, codes for a chloride canal in the neurons, which was not previously associated with blood-pressure regulation, and in an area on chromosome 17q21 there is the phopholipase gene, PLCD3, which is important for signaling in smooth muscles.


'/>"/>

Contact: Professor Ann-Christine Syvanen
ann-christine.syvanen@medsci.uu.se
46-018-611-2873
Uppsala University
Source:Eurekalert

Related biology news :

1. Scientists develop method for comprehensive proteome analysis
2. First comprehensive inventory of life in Antarctica
3. First comprehensive genomic study of common cold reveals new treatment targets
4. Collaboration between researchers yields more comprehensive portrait of brain cancer
5. Scientists launch first comprehensive database of human oral microbiome
6. U. of I. librarian launches comprehensive Web database of field guides
7. More comprehensive analysis of Klamath River basin needed to aid decision makers
8. University of Minnesota releases first ever comprehensive report of the health of college students
9. Leading researchers to reveal comprehensive dos and donts for prostate cancer
10. Study finds novel genetic risk factors for kidney disease
11. Genetic study confirms the immune systems role in narcolepsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They call it the “hairy ... a depiction of a system of linkages and connections so complex and dense ... of computer science at Worcester Polytechnic Institute (WPI) and director of the university’s ...
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer and recently formed ... entered into a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. The ... gene editing across all applications. , Under the terms of the agreement, Pioneer ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... with the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s ... hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... genomics analysis platform specifically designed for life science researchers to analyze and ... researcher Rosalind Franklin, who made a major contribution to the discovery of ...
Breaking Biology Technology: