Navigation Links
Compound useful for studying birth defects may also have anti-tumor properties

In an interesting bit of scientific serendipity, researchers at North Carolina State University have found that a chemical compound useful for studying the origins of intestinal birth defects may also inhibit the growth and spread of cancerous tumors.

During the screening of chemical compounds created by NC State chemist Dr. Alex Deiters, developmental biologist Dr. Nanette Nascone-Yoder found one of particular interest to her research: a compound that induced heterotaxia, a disordering or mirror-image "flipping" of internal organs, in the frog embryos she was studying. Nascone-Yoder is particularly interested in the genetic processes involved in proper formation of the gut tube, which later becomes the intestinal tract.

"For the intestinal tract to form properly, it has to develop asymmetrically. This compound disrupts asymmetry, so it could be quite useful in helping us to determine when and where intestinal development goes wrong in embryos," Nascone-Yoder says.

But the compound, dubbed "heterotaxin" by the researchers, had effects beyond just inducing heterotaxia.

"We also noticed that the compound prevents normal blood-vessel formation and prevents cells from migrating by increasing cellular adhesion basically, the cells are stuck together and can't move."

Nascone-Yoder and her collaborators searched for known genetic pathways that could regulate all of these different events, and found that the pathway most likely to be affected by heterotaxin was the TGF-beta pathway. TGF-beta is known to play a role in the progression of cancerous tumors from normal to metastatic.

"This was exciting, because tumors have to have cells that can migrate and form a blood supply in order for the cancer to spread," Nascone-Yoder adds. "Heterotaxin inhibits those processes, which may make it a good 'lead' candidate for the development of an anti-tumor drug."

Indeed, collaborative experiments with NC State veterinary oncologist Marlene Hauck and cell biologist Philip Sannes showed that heterotaxin quenches the growth of canine tumor cells, and inhibits some of the changes required for human tumor cells to become migratory and invasive at least in a petri dish. There is still work to do, but heterotaxin and future synthetic analogs could be the harbinger of a new class of cancer-fighting compounds.

The research is published in the Feb. 24 issue of Chemistry & Biology.


Contact: Tracey Peake
North Carolina State University

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
3. Discovery of natural compounds that could slow blood vessel growth
4. LSUHSC awarded patent for compound inhibiting cancer and other diseases
5. Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa
6. Design of a compound that stabilizes the main natural suppressor of tumors
7. New $11 million center to speed production of new compounds for drug discovery
8. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
9. Scripps research scientists identify compounds for stem-cell production from adult cells
10. Two new compounds show promise for eliminating breast cancer tumors
11. 2 new compounds show promise for eliminating breast cancer tumors
Post Your Comments:
(Date:11/10/2015)... 2015 About signature verification ... to identify and verify the identity of an ... the secure and accurate method of authentication and ... individual because each individual,s signature is highly unique. ... dynamic signature of an individual is compared and ...
(Date:11/9/2015)...  Synaptics Inc. (NASDAQ: SYNA ), the leading ... into the automotive market with a comprehensive and dedicated ... consumer electronics human interface innovation. Synaptics, industry-leading touch controllers, ... automotive industry and will be implemented in numerous locations ... , Japan , and ...
(Date:11/2/2015)... 2015  SRI International has been awarded a contract ... services to the National Cancer Institute (NCI) PREVENT Cancer ... expertise, modern testing and support facilities, and analytical instrumentation ... toxicology studies to evaluate potential cancer prevention drugs. ... Cancer Drug Development Program is an NCI-supported pipeline to ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... BRUSSELS , November 25, 2015 ... in cat and human plaque and pave the way for ... health problems in cats     ... the most commonly diagnosed health problems in cats, yet relatively ... until now. Two collaborative studies have been conducted by researchers ...
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris ... that its business and prospects remain fundamentally strong ... Zoptrex™ (zoptarelin doxorubicin) recently received DSMB recommendation to ... completion following review of the final interim efficacy ... 2 Primary Endpoint in men with heavily pretreated ...
(Date:11/25/2015)... , November 25, 2015 ... Research Report is a professional and in-depth study ...      (Logo: ) , ... of the industry including definitions, classifications, applications and ... provided for the international markets including development trends, ...
(Date:11/24/2015)... ... 2015 , ... The United States Golf Association (USGA) today announced Dr. Bruce ... Presented annually since 1961, the USGA Green Section Award recognizes an individual’s distinguished service ... , Clarke, of Iselin, N.J., is an extension specialist of turfgrass pathology in the ...
Breaking Biology Technology: