Navigation Links
Compound useful for studying birth defects may also have anti-tumor properties
Date:2/28/2011

In an interesting bit of scientific serendipity, researchers at North Carolina State University have found that a chemical compound useful for studying the origins of intestinal birth defects may also inhibit the growth and spread of cancerous tumors.

During the screening of chemical compounds created by NC State chemist Dr. Alex Deiters, developmental biologist Dr. Nanette Nascone-Yoder found one of particular interest to her research: a compound that induced heterotaxia, a disordering or mirror-image "flipping" of internal organs, in the frog embryos she was studying. Nascone-Yoder is particularly interested in the genetic processes involved in proper formation of the gut tube, which later becomes the intestinal tract.

"For the intestinal tract to form properly, it has to develop asymmetrically. This compound disrupts asymmetry, so it could be quite useful in helping us to determine when and where intestinal development goes wrong in embryos," Nascone-Yoder says.

But the compound, dubbed "heterotaxin" by the researchers, had effects beyond just inducing heterotaxia.

"We also noticed that the compound prevents normal blood-vessel formation and prevents cells from migrating by increasing cellular adhesion basically, the cells are stuck together and can't move."

Nascone-Yoder and her collaborators searched for known genetic pathways that could regulate all of these different events, and found that the pathway most likely to be affected by heterotaxin was the TGF-beta pathway. TGF-beta is known to play a role in the progression of cancerous tumors from normal to metastatic.

"This was exciting, because tumors have to have cells that can migrate and form a blood supply in order for the cancer to spread," Nascone-Yoder adds. "Heterotaxin inhibits those processes, which may make it a good 'lead' candidate for the development of an anti-tumor drug."

Indeed, collaborative experiments with NC State veterinary oncologist Marlene Hauck and cell biologist Philip Sannes showed that heterotaxin quenches the growth of canine tumor cells, and inhibits some of the changes required for human tumor cells to become migratory and invasive at least in a petri dish. There is still work to do, but heterotaxin and future synthetic analogs could be the harbinger of a new class of cancer-fighting compounds.

The research is published in the Feb. 24 issue of Chemistry & Biology.


'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
3. Discovery of natural compounds that could slow blood vessel growth
4. LSUHSC awarded patent for compound inhibiting cancer and other diseases
5. Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa
6. Design of a compound that stabilizes the main natural suppressor of tumors
7. New $11 million center to speed production of new compounds for drug discovery
8. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
9. Scripps research scientists identify compounds for stem-cell production from adult cells
10. Two new compounds show promise for eliminating breast cancer tumors
11. 2 new compounds show promise for eliminating breast cancer tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking events ... announced today. The bold new look is part of a transformation to increase ... a significant growth period. , It will also expand its service offering from its ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... At its ... Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has ... was a member of the winning team for the 2015 Breakthrough Prize in Fundamental ...
(Date:10/7/2017)... , Oct. 6, 2017  The 2017 ... of three scientists, Jacques Dubochet, Joachim Frank ... developments in cryo-electron microscopy (cryo-EM) have ... within the structural biology community. The winners worked ... can now routinely produce highly resolved, three-dimensional images ...
Breaking Biology Technology: