Navigation Links
Compound stymies polyomaviruses in lab tests
Date:11/13/2013

A team of scientists reports that a small molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened.

The compound, known by the abbreviated name "Retro-2," was able to protect the vast majority of cells in cultures when it was administered even after infection began. According to results published this week in the journal mBio, 12 days of treatment with Retro-2 kept 90.5 percent of cells free from JC Polyomavirus, 89 percent of cells clear of the BK Polyomavirus, and 84 percent of cells protected from the SV40 polyomavirus. Infection rates and virus production were much higher among cells in cultures that were similarly infected, but left untreated as controls.

That the compound gained the upper hand on viruses that had a head start is a key advance, said Brown University biologist Walter Atwood, corresponding author of the paper. Other substances have defeated the viruses only if they were used to pre-treat cells before any infection.

"But that's not reality," Atwood said. "The reality is that someone is already infected with the virus. Whenever in the past we first infected the cells with the virus and then came in with the drug, we've never been successful in being able to stop the spread of the virus. This drug is successful at that."

Brown University has a patent filed on the use of the compound against pathogen infections. The research also involved a team of scientists at Yale University led by Professor Daniel DiMaio.

An 'ER' medicine

Retro-2 appears to work by blocking the ability of polyomaviruses to sneak around host cells by hijacking the workings of the intracellular protein transportation hub: the endoplasmic reticulum (ER).


'/>"/>
Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
2. Biosensor illuminates compounds to aid fight against TB
3. New screening technique yields elusive compounds to block immune-regulating enzyme
4. Sulphur and iron compounds common in old shipwrecks
5. Heparin-like compounds inhibit breast cancer metastasis to bone
6. Like curry? New biological role identified for compound used in ancient medicine
7. Nuisance seaweed found to produce compounds with biomedical potential
8. Dont feel like exercise? Scientists find compound that may help you work out harder
9. New drug-screening method yields long-sought anti-HIV compounds
10. Nonstoichiometric Compounds V - An ECI Conference Series
11. New compound holds promise for treating Duchenne MD, other inherited diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Compound stymies polyomaviruses in lab tests
(Date:7/24/2014)... Imagine a smog-free Los Angeles, where electric cars ply ... run on heat from beneath the earth, from howling ... new Stanford study finds that it is technically and ... one powered by clean, renewable energy. Published in ... sustainable, inexpensive and reliable energy supply in California that ...
(Date:7/24/2014)... meaning the microbial populations found on surfaces in the ... final flavor according to research published ahead of print ... This is the first time investigators have taken a ... sake makers inoculate with both bacteria and yeast, says ... California, Davis, but he and his colleagues investigated a ...
(Date:7/24/2014)... at The University of Texas Health Science Center at ... to help Harris County residents whose vision problems cannot ... with corrective lenses, many people with low vision can ... of low vision devices, such as telescopes, magnifiers and ... Iyer is using the three-year, $164,645 SightFirst grant from ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4The microbes make the sake brewery 2UTHealth Dr. Bhavani Iyer awarded low vision grant 2
... coastal salt marshes affected by the BP Deepwater Horizon ... to oil exposure, but also resilient enough to recover within ... a study published Mar. 7 in the open access journal ... McCall and her advisor Steven Pennings at the University of ...
... 7, 2012) Scientists conducting deep-sea research in the Galapagos ... the March 5 issue of the journal Zootaxa. The ... chocolate-brown coloration with pale, irregularly distributed spots on its body. ... each individual. John McCosker of the California Academy of ...
... an area equivalent to 5 times the size of Germany, ... forest. The ,State of the Congo Basin Forests 2010, report ... Congo Basin Forest Partnership (CBFP), provides a comprehensive and detailed ... regulation and natural resources. It looks at deforestation patterns, points ...
Cached Biology News:New species of deep-sea catshark described from the Galapagos 2EU-funded study underlines importance of Congo Basin for global climate and biodiversity 2
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... today declared a $0.61 per share dividend for the ... on Sept. 5, 2014, to all stockholders of record ... 2014.  About Amgen Amgen is committed ... from serious illnesses by discovering, developing, manufacturing and delivering ...
(Date:7/25/2014)... A new study by researchers from the University ... tiny nanosystems function, unlocking the potential to create ... study, which has been published in the prestigious ... a novel laser technique to examine in rich ... a small cluster containing an acetylene molecule and ...
(Date:7/25/2014)... Albany, New York (PRWEB) July 25, 2014 ... Transparency Market Research, "Biological Drugs Market - Global Industry ... 2020," the global biological drugs market is estimated at ... grow at a CAGR of 10.1% from 2014 to ... million in 2020. , The biological drugs market is ...
(Date:7/25/2014)... The Conferee Networking committee is pleased to ... These two-hour sessions provide a unique networking opportunity for ... discuss new techniques, or brainstorm new ideas in an ... for consideration is August 31, 2014, and instructions can ... committee will review the topics, and status notifications will ...
Breaking Biology Technology:Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2
... slightly cloudy liquid. Yellow, oily, bacterial ... each containing 10 ml of Freund's ... proportions by weight: 85% Drakeol 5NF, ... and 0.1% Mycobacterium butyricum ...
... Easy and Cost effective - Utilizes hands-off ... , No grinding - Extract DNA ... grinding tools between samples , Robust ... beat and homogenize without tube breakage , ...
... secretion of cytoplasmic granules, is a ... of leukocytes (e.g. basophils, neutrophils, eosinophils, ... histamine, these secretory granules contain many ... and many proteases (Hallgren, 2001). Tryptase, ...
... youll be telling others after you read your ... One look at the table of contents of ... interaction will tell you immediately that this is ... your personal protein chemistry library. You will want ...
Biology Products: