Navigation Links
Compound stimulates tumor-fighting protein in cancer therapy
Date:2/6/2013

ffect. It is effective in cancer cell samples and cell lines resistant to conventional therapies.

"I was surprised and impressed that we were able to do this," El-Deiry said. "Using a small molecule to significantly boost and overcome limitations of the TRAIL pathway appears to be a promising way to address difficult to treat cancers using a safe mechanism already used in those with a normal effective immune system. This candidate new drug, a first-in-its-class, shows activity against a broad range of tumor types in mice and appears safe at this stage."

New treatments are needed for advanced cancer, as more than half a million people in the United States will die of cancer in 2013.

"We have enough preclinical information to support the rationale for testing this new drug in the clinic," El-Deiry said.

TIC10 seems to be nontoxic to normal cells or mice even at doses 10 times higher that an observed therapeutic dose. However, more research needs to be completed to satisfy FDA requirements prior to initiation of clinical testing.


'/>"/>

Contact: Matthew Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2

Related biology news :

1. Beers bitter compounds could help brew new medicines
2. New compound overcomes drug-resistant Staph infection in mice
3. Promising compound restores memory loss and reverses symptoms of Alzheimers
4. A new breed of stable anti-aromatic compound
5. Compound in grapes, red wine could be key to fighting prostate cancer
6. Scientists identify insect-repelling compounds in Jatropha
7. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
8. Screening technique uncovers 5 new plant activator compounds
9. Mushroom-derived compound lengthens survival in dogs with cancer, Penn Vet study finds
10. Compound discovered that boosts effect of vaccines against HIV and flu
11. MMV develops framework to assess risk of resistance for antimalarial compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group issues ... (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one of ... on their experience with the Wocket in multiple scenarios and ... Whole Foods and other retailers, making both debit and credit ... also says, "If the company meets their plans in ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2013 ...
(Date:3/17/2015)... , March 17, 2015 MedNet ... specializing in clinical study management systems, is pleased ... attendance at ARENA,s Outsourcing in Clinical Trials Southeast ... event provides an excellent forum for MedNet to ... and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... certified winner of the UC Davis "Western Cooling Challenge" ... that their five-ton commercial rooftop unit should be able ... half the energy needed by conventional cooling units. ... first to take our rigorous tests at the Advanced ...
... Leipzig Max Planck Institute for Human Cognitive and Brain ... London have now developed a mathematical model which could ... language. In the future, this kind of algorithms which ... world around them. Many people will have personal ...
... cells for replication and production of virus progeny. Thus ... induces therapy resistance. New improved therapies attempt to targets ... The team led by Professor Dr. Ralf Bartenschlager, ... Hygiene Institute of Heidelberg University Hospital, has identified a ...
Cached Biology News:UC Davis challenge produces a better air conditioner 2Doing what the brain does -- how computers learn to listen 2Doing what the brain does -- how computers learn to listen 3New strategy for inhibiting virus replication 2
(Date:4/21/2015)... April 21, 2015  Novogen Limited (ASX:NRT; NASDAQ: ... advises that it has entered into definitive agreements ... shares plus one attaching 6-month option and half ... share issued, to institutional investors in ... placement for aggregate gross proceeds of approximately AU$15,500,000 ...
(Date:4/21/2015)... Springfield, Mo. (PRWEB) April 21, 2015 ... vessels, HOLLOWAY AMERICA is slated to discuss its custom ... also present its reimagined website, which launched just prior ... Wed. and Thurs. (April 21, 22 and 23) at ... than 12,000 representatives of the world’s largest and most ...
(Date:4/20/2015)... Winston-Salem, NC and Champaign, IL (PRWEB) April 20, 2015 ... announced today the establishment of its 12th clinical research ... 2015, PMG Research has assumed operation of the clinical ... IL, expanding PMG’s footprint outside the Southeast to a ... site within a 150 multi-specialty physician practice enhances PMG’s ...
(Date:4/20/2015)... -- "Everybody is affected by cancer sooner or later," Dr. ... We,ve got to get away from that."  If you,ve ... loved one or friend battling for their life against ... other treatments cause the human body. It,s almost enough ... succumb to the disease. Dr. Dionne has developed a ...
Breaking Biology Technology:Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 2Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 3Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 4Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 5Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 6HOLLOWAY AMERICA to Reveal Newly Designed Responsive Website at INTERPHEX 2015 Today 2HOLLOWAY AMERICA to Reveal Newly Designed Responsive Website at INTERPHEX 2015 Today 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Is Dr. Craig Dionne the Steve Jobs of Cancer Research? 2
... First tenant moves in Stevenage Bioscience Catalyst ... to announce that it is now open for business. In ... , which has taken space in the Incubator building. SBC ... one - discussions with a range of interesting tenants are ...
... Biosciences, a segment of BD (Becton, Dickinson and Company), ... Mesenchymal Stem Cell Serum-Free (hMSC SF), a complete cell ... from bone marrow. The BD Mosaic ... expansion in a shorter culture time—about half the time ...
... 2012  New England Biolabs, Inc. (NEB) and Synthetic Genomics, ... a licensing agreement whereby NEB will introduce a master ... by Dr. Daniel Gibson and his colleagues at the ... program sponsored by SGI. The financial details of this ...
Cached Biology Technology:Stevenage Bioscience Catalyst Opens With Exciting Year Ahead 2Stevenage Bioscience Catalyst Opens With Exciting Year Ahead 3Stevenage Bioscience Catalyst Opens With Exciting Year Ahead 4Stevenage Bioscience Catalyst Opens With Exciting Year Ahead 5Stevenage Bioscience Catalyst Opens With Exciting Year Ahead 6Mesenchymal Stem Cells Have New Cell Culture Environment 2New England Biolabs Signs Agreement with Synthetic Genomics Inc. to Launch Gibson Assembly™ Master Mix for Molecular and Synthetic Biology Applications 2New England Biolabs Signs Agreement with Synthetic Genomics Inc. to Launch Gibson Assembly™ Master Mix for Molecular and Synthetic Biology Applications 3
... Blot Processing Standard Tray (3 per ... gel staining and blot processing.Automated staining ... for proteins and nucleic acid analysis.Prepares ... and chromogenic detection.Programmable control of protocol, ...
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
GOAT ANTI HUMAN PARAINFLUENZA VIRUS 2+3...
75 x 25 mm; sterile, recommended for immunohistochemistry of cell lines growing in suspension, Poly-D-Lysine coated, glass slides with polystyrene vessel, lid and safety removal tool...
Biology Products: