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Compound screening for drug development made simpler
Date:3/24/2010

les that can be incorporated into the software used to screen chemical libraries.

The filters were made publically available on 4 February through online publication in the Journal of Medicinal Chemistry.

High-throughput chemical screening has been used by large pharmaceutical companies for more than 20 years. In the past decade scientists at universities and research institutes and in small biotechnology companies have had increasing access to HTCS. "Many of them have spent vast amounts of time and money optimising and patenting molecules that were never going to amount to anything," Dr Baell said.

"We were in a position where we had all the data, we had the software, and we had the expertise to identify these molecules. Importantly, we also had the ability to publish our data.

"Pharmaceutical companies, which have used high-throughput chemical screening for many years, would know about many compounds that turn up as false positives. But they also operate in a competitive environment where publishing this data could compromise their competitive edge. For this particular situation, we didn't have such constraints."

Dr Baell said that within 48 hours of publishing the filters he was contacted by a number of pharmaceutical companies wishing to use them to assess their impact on their own high throughput screening libraries."


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Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

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