Navigation Links
Compound in celery, peppers reduces age-related memory deficits
Date:10/13/2010

, that luteolin improves cognitive health by acting directly on the microglial cells to reduce their production of inflammatory cytokines in the brain.

The researchers showed that microglial cells that were exposed to a bacterial toxin produced inflammatory cytokines that could kill neurons. When the microglia were exposed to luteolin before they encountered the toxin, however, the neurons lived.

"The neurons survived because the luteolin inhibited the production of neurotoxic inflammatory mediators," Johnson said.

Exposing only the neurons to luteolin before the experiment had no effect on their survival, the researchers found.

"This demonstrated that luteolin isn't protecting the neurons directly," he said. "It's doing it by affecting the microglial cells."

The researchers next turned their attention to the effects of luteolin on the brains and behavior of adult (3- to 6-month-old) and aged (2-year-old) mice. The mice were fed a control diet or a luteolin-supplemented diet for four weeks. The researchers assessed their spatial memory and measured levels of inflammatory markers in the hippocampus, a brain region that is important to memory and spatial awareness.

Normally, aged mice have higher levels of inflammatory molecules in the hippocampus and are more impaired on memory tests than younger adult mice. Aged mice on the luteolin-supplemented diet, however, did better on the learning and memory task than their peers, and the levels of inflammatory cytokines in their brains were more like those of the younger adult mice.

"When we provided the old mice luteolin in the diet it reduced inflammation in the brain and at the same time restored working memory to what was seen in young cohorts," Johnson said.

Studies have shown that plant compounds such as luteolin can get into the brain, Johnson said. "We believe dietary luteolin accesses the brain and inhibits or reduces activation of microglial ce
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
3. Discovery of natural compounds that could slow blood vessel growth
4. LSUHSC awarded patent for compound inhibiting cancer and other diseases
5. Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa
6. Design of a compound that stabilizes the main natural suppressor of tumors
7. New $11 million center to speed production of new compounds for drug discovery
8. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
9. Scripps research scientists identify compounds for stem-cell production from adult cells
10. Two new compounds show promise for eliminating breast cancer tumors
11. 2 new compounds show promise for eliminating breast cancer tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Compound in celery, peppers reduces age-related memory deficits
(Date:12/3/2014)...   Marvin Test Solutions , a trusted ... military, aerospace, and manufacturing organizations, today announced the ... TS-900 PXI semiconductor test platform . The TS-960 ... to customers at a fraction of the footprint ... "Our semiconductor customers asked for ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/21/2014)... 20, 2014 Strict laws against distracted driving ... the North American and European automotive sector towards gesture ... recognition systems that are intuitive and able to retrieve ... industry. New analysis from Frost & ... in Europe and ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... Soybean production has continued to increase in the Northeast ... the crop and many experienced growers planting alongside corn crops. ... with a corn planter in 30-inch rows instead of 7.5-inch ... a Cornell University scientist, investigated the response of two soybean ...
... L. Boren announced today that OU is establishing an ... expertise to benefit Oklahoma and the nation, including emerging ... led by a national expert, who will be appointed ... million gift from Corix, a multi-utility infrastructure company, which ...
... grant totaling $2.2 million shows how the University of ... using technology to advance the cutting-edge field of personalized ... their genetic make-up. The grant also highlights the ... Institute (CCTSI) to bring scientific discoveries to the bedside ...
Cached Biology News:OU establishes a new water and sustainability institute 2OU establishes a new water and sustainability institute 3Personalizing medicine 2Personalizing medicine 3
(Date:12/22/2014)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... development of autologous cell therapies, announced today the publication ... in conjunction with co-authors from Kyoto University and the ... ongoing clinical research using dermal sheath cup (DSC) cells ... The paper entitled " Hair Follicle Dermal Stem Cells ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a new ... network of more than 20 contributing fertility practices ... access to a national pool of frozen donor ... of Memphis is the only fertility clinic in the ... Dr. William Kutteh , director of Fertility Associates of ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of ... Nick Maroulis, Pharm.D. to the newly created position of ... this position, Dr. Maroulis will continue to manage the ... our multi-site pharmacies as the company expands. Dr. Maroulis ... time he has served in many different capacities in ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... 4, 2011 Enox Biopharma, Inc., a leader in the ... today announced that it has appointed John C. Rewcastle, Ph.D., ... Enox, Dr. Rewcastle served as Medical Director of EDAP TMS ... Medical, a private medical device company. Prior to this, he ...
... Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX ) today announced ... presenting at the 29th Annual J.P. Morgan Healthcare Conference, being ... in San Francisco. Mr. Bentsur,s presentation is scheduled to take ... p.m. EST). A live audio webcast of Mr. ...
... 4, 2011 Reportlinker.com announces ... report is available in its ... title=,The 2011 Clinical Chemistry And ... Product Development Opportunities And Business ...
Cached Biology Technology:Enox Biopharma, Inc. Appoints Dr. John Rewcastle as CEO 2Enox Biopharma, Inc. Appoints Dr. John Rewcastle as CEO 3Keryx Biopharmaceuticals to Present at 29th Annual J.P. Morgan Healthcare Conference 2Reportlinker Adds The 2011 Clinical Chemistry And Immunodiagnostics Markets US, Europe, Japan: Product Development Opportunities And Business Expansion Strategies For Instrument And Reagent Suppliers 2
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
... and SYBR Safe DNA Gel Stain combo offers these ... buying these same products separately ... bromide Eliminates risks to ... and RNA fragments from 100 bp to >30 kb. ...
... easily imported for data analysis , Automatic grid, ... template assignment ... Extensive background and signal options to optimize, ... results , ...
... MATra-si Reagent optimized for siRNA applications, contains ... with the nucleic acid of interest. Exploiting ... is then rapidly drawn towards and delivered ... transfection. MATra-si Reagent can be used for ...
Biology Products: