Navigation Links
Compound improves cardiac function in mice with genetic heart defect, MU study finds
Date:2/20/2014

COLUMBIA, Mo. Congenital heart disease is the most common form of birth defect, affecting one out of every 125 babies, according to the National Institutes of Health. Researchers from the University of Missouri recently found success using a drug to treat laboratory mice with one form of congenital heart disease, hypertrophic cardiomyopathy a weakening of the heart caused by abnormally thick muscle. By suppressing a faulty protein, the researchers reduced the thickness of the mice's heart muscles and improved their cardiac functioning.

Maike Krenz, M.D., has been studying hypertrophic cardiomyopathy for more than 10 years, soon after a gene was discovered in 2001 that linked the disease to the genetic conditions Noonan syndrome and LEOPARD syndrome. In Noonan and LEOPARD syndromes, the thickened heart muscle of hypertrophic cardiomyopathy is caused by a defective Shp2 protein, created by a mutation in the gene PTPN11.

"Previously, not much has been known about the biochemistry behind Shp2 and hypertrophic cardiomyopathy," said Krenz, an assistant professor of medical pharmacology and physiology at the MU School of Medicine, and a researcher at MU's Dalton Cardiovascular Research Center. "We know the thickened heart muscle is sick and doesn't work properly, and we know a defective Shp2 protein can cause heart muscle to thicken. However, to create an effective treatment, we need to know what Shp2 is doing inside the heart to cause the defect."

To test whether they could interrupt the heart's hypersensitivity to growth signals, the researchers gave a chemical compound, PHPS1, to mice with a mutated gene that produces the defective Shp2 protein.

"Not only did the compound reduce the thickness of the heart muscle to the size of normal heart muscle, but it also improved the cardiac pumping of the heart," Krenz said. "That's important because people with hypertrophic cardiomyopathy have an increased risk of sudden cardiac death. If we could develop an effective treatment for the disease and improve patients' heart function, we would be able to improve health outcomes for these patients."

Because of the role Shp2 plays in signaling heart growth, Krenz believes the research could be translated in the future into improved treatments for other types of heart disease, such as damage caused by heart attack.


'/>"/>
Contact: Colin Planalp
planalpc@health.missouri.edu
573-884-1935
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
2. Biosensor illuminates compounds to aid fight against TB
3. New screening technique yields elusive compounds to block immune-regulating enzyme
4. Sulphur and iron compounds common in old shipwrecks
5. Heparin-like compounds inhibit breast cancer metastasis to bone
6. Like curry? New biological role identified for compound used in ancient medicine
7. Nuisance seaweed found to produce compounds with biomedical potential
8. Dont feel like exercise? Scientists find compound that may help you work out harder
9. New drug-screening method yields long-sought anti-HIV compounds
10. Nonstoichiometric Compounds V - An ECI Conference Series
11. New compound holds promise for treating Duchenne MD, other inherited diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... Research and Markets has announced the addition of the ... The global biomarkers market has ... The market is expected to grow at a five-year compound annual ... $50.6 billion in 2015 to $96.6 billion in 2020. ... to 2020) are discussed. As well, new products approved in 2013 ...
(Date:6/22/2016)... 2016   StockNewsNow.com , The Official MicroCap News ... Nader Pourhassan , President & CEO of CytoDyn ... clinical development and potential commercialization of humanized monoclonal antibodies ... to the company,s website (see here: www.CytoDyn.com ). ... th , 2016, at the LD Micro Invitational in ...
(Date:6/22/2016)... --  ViaCyte, Inc. , a privately-held regenerative medicine company ... for the treatment of diabetes in clinical-stage development, today ... 2016, the Global Stem Cell Event, is taking place ... Francisco.    ... Focus Session: Tools for Basic and Applied Stem Cell ...
(Date:6/22/2016)... ... June 22, 2016 , ... ... spotlight on immigrant achievements and contributions to North Texas and the nation, recently ... from the immigrant community to the civic and economic vitality of North Texas. ...
Breaking Biology Technology: