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Complications early in pregnancy or in previous pregnancies adversely affect existing or subsequent pregnancies
Date:6/28/2009

ing pregnancy of preterm premature rupture of the membrane that surrounds the baby in the womb, and increased the risk of premature or very premature delivery (earlier than 37 or 34 weeks respectively). Recurrent miscarriages (three or more miscarriages) increased the risk in a subsequent pregnancy of all of these conditions; in addition, it increased the risk of placenta praevia (where the placenta partially or completely blocks the cervix) six-fold and congenital malformations nearly two-fold. If a previous pregnancy had to be terminated for any reason, this increased the risk of premature rupture of the membrane, premature and very premature delivery in subsequent pregnancies.

Dr van Oppenraaij said: "The finding of a six-fold risk of placenta praevia needs to be treated with caution as it came from one, small, retrospective study. More and larger studies are needed to confirm this finding."

If problems were encountered in the first trimester of an ongoing pregnancy, this increased the risk of further complications later on in the same pregnancy. For instance, vaginal bleeding in the first trimester increased the risk of preeclampsia, premature or very premature delivery and more than doubled the risk of low birth weight and very low birth weight. These risks were further increased after detection of an intrauterine haematoma. The survivor in a vanishing twin pregnancy (a twin pregnancy in which one twin miscarries very early in the pregnancy) was at increased risk of premature or very premature delivery, had double the risk of low birth weight, three times the risk of very low birth weight, and more than three times the risk of perinatal death. Extreme early morning sickness (hyperemesis gravidarum) was associated with a three-fold increased risk of premature delivery and a nearly three-fold risk of low birth weight.

Dr van Oppenraaij said: "While it is true that most conditions are difficult to prevent, with improved
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Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
Source:Eurekalert

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