Navigation Links
Complexity of Crohn's disease revealed as 'gene' count tops 30
Date:6/29/2008

wide association studies have led to an explosion in the number of genes known to be implicated in complex diseases such as diabetes, heart disease and Crohn's disease. The first two Crohn's disease susceptibility genes were discovered in 2001, followed by a third in 2006. The Wellcome Trust Case Control Consortium and parallel studies took that number above ten the following year using genome wide association studies. This number has now almost trebled to thirty-two.

Amongst the findings are loci containing genes known to be implicated in a number of other common diseases including diabetes, rheumatoid arthritis and psoriasis. However, the genetic relationship between Crohn's and these other diseases is not always straightforward. For example, the genetic variant PTPN2 appears to increase susceptibility to both Crohn's disease and type 1 diabetes. But the similarly named PTPN22 increases the risk of developing type 1 diabetes, yet appears to offer protection from Crohn's.

Although some of the disease connections were unsurprising there is already a known epidemiological correlation between Crohn's disease and psoriasis, for example the ORMDL3 gene on chromosome 17 provided the most unexpected link. ORMDL3 was already known to be a genetic risk factor for childhood asthma, but until now, no epidemiological link had ever been seen between asthma and Crohn's disease.

"It's too early for us to say how Crohn's disease and many of these other diseases, including asthma, are linked at a biological level," says Dr Miles Parkes, Consultant Gastroenterologist at Addenbrooke's Hospital and the University of Cambridge, who also worked on the study. "However, we are building up a picture of the biology underlying Crohn's disease, and the more we understand about the underlying biology of these diseases, the better equipped we will be to treat them.

"Studies such as this are not about developing diagnostic tests, but about identifying targe
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-8866
Wellcome Trust
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Organic corn: Increasing rotation complexity increases yields
2. Simple model cell is key to understanding cell complexity
3. Finding God with biocomplexity
4. Evolving complexity out of junk DNA
5. Upper Midwest forests are losing diversity, complexity, ISU study finds
6. Unravelling new complexity in the genome
7. UIC researchers make promising finding in severe lung disease
8. International team identifies 21 new genetic risk factors for Crohns disease
9. Certain anticancer agents could be harmful to patients with heart disease
10. Best code for disease detection, bar none
11. New discoveries from Harvard and Baylor get to the heart of cardiovascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... ecosystems can get messy, especially when trying to predict ... change. , In a new paper published this ... National Academy of Sciences , researchers from the University ... the very heart of a popular way to predict ... changes may impact biodiversity, researchers like Jessica Blois and ...
(Date:5/24/2013)... 2013 A frequently expressed concern in the ongoing public ... vegetables, especially those that are nutrient dense. A ... Beans Provide Most Nutrients Per Penny," published in the ... one of the best nutritional values in the produce ... penny than most other raw vegetables and delivering one ...
(Date:5/24/2013)... growing open-access publishers, today announces the launch of a ... broad scope journal covering all specialties, Frontiers in ... platform for the research community to publish high quality ... interactive peer-review enables fast, fair and constructive review of ... three months from submission to final decision for a ...
Breaking Biology News(10 mins):Understanding the past and predicting the future by looking across space and time 2New research shows that potatoes provide one of the best nutritional values per penny 2Frontiers launches new open-access journal in physics 2Frontiers launches new open-access journal in physics 3
... Philadelphia, PA -- The Academy of Nutrition and Dietetics ... for Medicare and Medicaid Services (CMS) to expand coverage ... hypertension, obesity, and cancer, as part of the CMS ... conditions can be controlled or treated with medical nutrition ...
... RIVERSIDE, Calif. Four researchers at the University of California, ... the Advancement of Science ( AAAS ). Including this year,s ... have been recognized with AAAS Fellow distinction is 194. ... members by their peers. This year AAAS gave this honor ...
... what midwives view as the overly medicalized way hospitals ... the message that women,s bodies know best. The ... that home birth is about female empowerment, strengthening relationships ... put mothers in control, with the ultimate goal of ...
Cached Biology News:The Academy of Nutrition and Dietetics advocates for expanded nutritional coverage under Medicare 2The Academy of Nutrition and Dietetics advocates for expanded nutritional coverage under Medicare 34 UC Riverside researchers receive national recognition 2Midwives use rituals to send message that women's bodies know best 2Midwives use rituals to send message that women's bodies know best 3
(Date:5/23/2013)... 23, 2013  Saddleback Memorial Medical Center in ... first hospital on the West Coast to perform a ... option provides women with a state-of-the-art, minimally invasive approach ... Winter , M.D., a highly regarded ... director of minimally invasive surgery at Saddleback Memorial, led ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 On April ... trips to supermarkets to search for the growing antibiotic ... aisles. Results from a year long study were released ... in foods, specifically meats, over previous years. For those ... the growth of antibiotic resistant bacteria in food, may ...
(Date:5/23/2013)... Washington, DC (PRWEB) May 23, 2013 ... African-Americans in STEM industries, Black Data Processing Associates (BDPA), ... Day on June 8, 2013. This all-day event will ... arena, and learn the ins and outs from many ... to 3 p.m. at the New Jersey Institute of ...
(Date:5/23/2013)... During the conduct of research involving ... principles of good clinical practice (GCP) and human ... Lim, Fellow, Clinical Development at Novartis Pharmaceuticals, will ... the International Conference on Harmonization (ICH) Guideline for ... the conduction of clinical trials ,     Apply ...
Breaking Biology Technology:Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3Acne Cream, Probiotic Action Shares News on How Some Food may Breed Acne Causing Bacteria 2Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Adhering to Good Clinical Practice, New Webinar Hosted by Xtalks 2
... Created Role of Senior Vice President of ... Philip R. Licari to Step Down as Chief Operating Officer upon Closing ... ... ), the manufacturer of the NxStage System One (TM),portable kidney dialysis machine, today ...
... SAN CARLOS, Calif., Aug. 29 Nektar,Therapeutics (Nasdaq: ... Lingnau has been,appointed to serve on its board ... with over 35 years of experience in,corporate management, ... to Nektar extensive pharmaceutical development and,commercialization experience at ...
... Colo., Aug. 29 Pharmion Corporation,(Nasdaq: PHRM ... Drug Administration,(FDA) has granted Fast Track designation for ... Fast Track programs are designed to facilitate ... that are intended to treat serious or,life-threatening conditions ...
Cached Biology Technology:NxStage Medical Provides Update on Medisystems Acquisition 2NxStage Medical Provides Update on Medisystems Acquisition 3NxStage Medical Provides Update on Medisystems Acquisition 4NxStage Medical Provides Update on Medisystems Acquisition 5Nektar Therapeutics Appoints Lutz Lingnau as New Board Member 2Nektar Therapeutics Appoints Lutz Lingnau as New Board Member 3Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 2Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 3Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 4Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 5Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 6
Glucagon-like peptide-1 (GLP-1 (1-36) amide)...
... LC Sciences provides a comprehensive microarray ... regulatory/functional RNA embedded within non-coding RNAs ... and proprietary probe design, which enables ... of small RNAs (1). This comprehensive ...
... LC Sciences provides a comprehensive ... protein kinase substrate (PKS) peptide microarrays ... proteomic scale kinase profiling, quantitative measurement ... discovery research. This comprehensive service includes ...
... Sciences provides a unique new tool, OligoMix ... serving diverse needs in genomics, proteomics, synthetic ... is a MIXTURE of a large number ... in a single microtube. OligoMix is made ...
Biology Products: